The article discusses the implications of health research in Primary Health Care (PHC). It analyses how the knowledge produced by the scientific investigation impacts the PHC services routine, emphasizing results production, dissemination, and use processes. Therefore, a participatory research of case study type, anchored in the constructivist theory, was carried out. PHC health professionals, managers and technicians of the Health Secretariat of the State of Ceará, Brazil, and the Municipal Health Secretariat of Fortaleza participated in the study. The hermeneutic-dialectical circle technique was used to collect information, and the empirical material analysis was based on critical hermeneutics. In the results, aspects related to the choice of research topics, relevance of investigations, and the use of the results for well-informed decision-making are discussed. To overcome the obstacles found in the production, dissemination, and use of the research results, we suggest a research priority agenda be developed at the municipal level, from which the problems of PHC would be listed, prioritized, and investigated based on a participatory methodology, capable of engaging all those involved.