Atenolol: side effects in a newborn infant.

Abstract

SHORT REPORTSReversible male subfertility due to hyperthyroidism Hyperthyroidism in women may cause oligomenorrhoea, amenorrhoea, and failure of ovulation. In men gonadal dysfunction is less apparent, though loss of libido, reduced potency,' and gynaecomastia2 may occur. We describe a man who presented with subfertility due to thyrotoxicosis and in whom normal fertility was restored with antithyroid drug treatment. Case reportA 26-year-old man with a one-year history of attempted conception was referred to a male subfertility clinic. Two previous semen analyses had disclosed oligospermia with sperm counts of 11 x 109/1 on both occasions (figure). He had had classical symptoms of thyrotoxicosis for five years and 18 months earlier had been investigated for palpitations.Examination showed a diffuse goitre, tremor, and tachycardia; vitiligo was present on the arms, trunk, and penis. There was no gynaecomastia and the testes were normal. Hyperthyroidism was confirmed biochemically: serum thyroxine concentration was 267 mmol/l (20-7 4g/100 ml) (normal range 70-160 mmol/l; 5-4-12-4 ,ug/10O ml) and free thyroxine index >500 (normal range 70-180). Basal serum luteinising hormone, follicle-stimulating hormone, and prolactin concentrations were normal. Serum testosterone

The Risk for Neonatal Hypoglycemia and Bradycardia after Beta-Blocker Use during Pregnancy or Lactation: A Systematic Review and Meta-Analysis

“…Table 6 shows the quality of the nine case series [ 26 , 27 , 48 , 56 , 57 , 61 , 62 , 64 , 65 ]. Table 7 shows the quality of the 15 case reports [ 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 ].…”

“…Forty-one of the fifty-five included articles examined whether bradycardia was found in neonates exposed to beta-blockers either in utero or during lactation [ 27 , 28 , 30 , 32 , 33 , 34 , 35 , 37 , 38 , 40 , 43 , 44 , 45 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 55 , 56 , 57 , 58 , 59 , 60 , 62 , 64 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 ]. Table 8 presents 28 of the articles [ 27 , 28 , 30 , 32 , 33 , 34 , 35 , 37 , 38 , 40 , 43 , 44 , …”

“…Table 8 presents 28 of the articles [ 27 , 28 , 30 , 32 , 33 , 34 , 35 , 37 , 38 , 40 , 43 , 44 , 45 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 55 , 56 , 57 , 58 , 59 , 60 , 62 , 64 ] that reported on the heart rate of neonates exposed to beta-blockers in utero. The other thirteen articles are case reports [ 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 ], which are described in Section 3.6 . One case in the study of Boutroy et al [ 48 ] had hypotension.…”

“…Forty-seven out of the 55 included articles investigated the occurrence of hypoglycemia in neonates exposed to beta-blockers either in utero or during lactation [ 26 , 28 , 29 , 30 , 31 , 32 , 33 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 49 , 50 , 52 , 53 , 54 , 55 , 57 , 58 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 70 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 ]. Table 10 shows 34 of the articles reporting hypoglycemia and the definitions used by the authors [ 26 , 28 , 29 , 30 , 31 ,…”

Side effects of labetalol in newborn infants

“…Various cardioselective P-adrenergic blocking agents have been used with some success in the control of hypertension during pregnancy although side effects in the newborn infants have been reported (Dumez et al 1981: Woods & Morrell 1982. Lagercrantz & Bistoletti (1977) showed that the concentrations of catecholamines in the cord blood at birth are elevated, especially after a complicated delivery.…”