ATF3 Activates Stat3 Phosphorylation through Inhibition of p53 Expression in Skin Cancer Cells

Hao, Zhenfeng; J, Ao; Zhang, Jie; Su, Yirong; Yang, Rongya

doi:10.7314/apjcp.2013.14.12.7439

Cited by 25 publications

(21 citation statements)

References 38 publications

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“…In PC3 and DU145 cancer cells, it was found that overexpression of ATF-3 increased CCND1/2 expression, and SUMOylation played a functional role in ATF-3-mediated cellular proliferation [31]. In skin cancer, ATF-3 promoted cell proliferation which was dependent on the p53-Stat3 signaling [33]. It is also noted that overexpression of ATF3 in primary mouse chondrocytes resulted in reduced transcription of cyclin A and D1 genes [31], and ATF-3 induction is likely to facilitate cell cycle exit, suggesting that the effects of ATF-3 on cellular physiology are likely to be context-and cell type-dependent.…”

Section: Discussionmentioning

confidence: 99%

Runx2, a target gene for activating transcription factor-3 in human breast cancer cells

2014

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Activating transcription factor (ATF-3) is a stress response gene and is induced by transforming growth factor beta 1 (TGF-β1) in breast cancer cells. In this study, we dissected the functional role of ATF-3 gene in vitro by knocking down its expression stably in human bone metastatic breast cancer cells (MDA-MB231). Knockdown of ATF-3 expression in these cells decreased cell number, altered cell cycle phase transition, and decreased mRNA expression of cell cycle genes. Knockdown of ATF-3 expression in MDA-MB231 cells also decreased cell migration, and the expression levels of invasive and metastatic genes such as MMP-13 and Runx2 were found to be decreased in these cells. Most importantly, ATF-3 was associated with Runx2 promoter in MDA-MB231 cells and knockdown of ATF-3 expression decreased its association with Runx2 promoter. Hence, our results suggested that ATF-3 plays a role in proliferation and invasion of bone metastatic breast cancer cells in vitro and we identified for the first time that Runx2 is a target gene of ATF-3 in MDA-MB231 cell line.

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Section: Discussionmentioning

confidence: 99%

Runx2, a target gene for activating transcription factor-3 in human breast cancer cells

2014

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“…Alterations in Stat3 phosphorylation status followed with change of cancer cell proliferation, cellular apoptosis and chemo-and radio-therapeutic sensitivity in colorectal cancer, small cell lung cancer, skin cancer cell, ovarian cancer cell and non-small cell lung adenocarcinoma cell line (Abdulghani et al, 2008;Liu et al, 2011;Zhao et al, 2012;Hao et al, 2013;Sun et al, 2013;Zhu et al, 2013). …”

Section: Discussionmentioning

confidence: 99%

Radiation Induces Phosphorylation of STAT3 in a Dose- and Time-dependent Manner

Gao

Li²,

Chen³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Asian Pac J Cancer Prev, 15 (15), 6161-6164 IntroductionRadiotherapy is one of the common approaches for cancer therapy. It can be used alone or in combination with chemotherapy and/or surgery. Radiotherapy has shown therapeutic effect for most type of cancer including lung cancer, even has a curative potential in many solid human tumors (Krause et al., 2011), such as head and neck carcinoma and non-small cell lung cancer (Budach et al., 2005;Baumann et al., 2011). However, despite continuous progression of radiotherapy technology, a high proportion of patients will still die from tumor recurrence and metastasis due to the cancer cells with radioresistance (Rycaj et al., 2014). Radiation acts by inhibiting cell proliferation or inducing apoptotic cell death (Fu et al., 1991). However, radiaiton can also activate various radiation response genes. This leads to the production of various proteins, some of which might change the radiosensitivity of cancer cell and confer survival advantage to cancer cells. The survival cancer cells after radiation contributed to the recurrence and metastasis of cancer.The transcription factor Signal Transducer and

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“…Skin cancer is an important research topic in China (Deng et al, 2013;Hao et al, 2013;Wang et al, 2013;Wu et al, 2013). CSCC with distant metastasis, while rare, is more common than metastatic basal cell cancer.…”

Section: Discussionmentioning

confidence: 99%

Evidence Based Analysis of Cisplatin for Treating Patients with Cutaneous Squamous Cell Carcinoma

Shao

Xu²,

Zhang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: This analysis was conducted to evaluate the efficacy and safety of cisplatin based chemotherapy for treating patients with cutaneous squamous cell carcinoma. Methods: Clinical studies evaluating the efficacy and safety of cisplatin based regimens on response and safety for patients with cutaneous squamous cell carcinoma were identified using a predefined search strategy. Pooled response rates (RR) of treatment were calculated. Results: In cisplatin based regimens, 4 clinical studies which including 50 patients with advanced cutaneous squamous cell carcinoma were considered eligible for inclusion. Regimens included cisplatin, doxorubicin, or vindesine. Pooled analysis suggested that, in all patients, the pooled RR was 60% (30/50) in cisplatin based regimens. Nausea and vomiting were the main side effects. No grade III or IV renal or liver toxicity were observed. No treatment related death occurred with the cisplatin based treatments. Conclusion: Evidence based analysis suggests that cisplatin based regimens are associated with a good response rate and acceptable toxicity for treating patients with cutaneous squamous cell carcinoma.

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ATF3 Activates Stat3 Phosphorylation through Inhibition of p53 Expression in Skin Cancer Cells

Cited by 25 publications

References 38 publications

Runx2, a target gene for activating transcription factor-3 in human breast cancer cells

Runx2, a target gene for activating transcription factor-3 in human breast cancer cells

Radiation Induces Phosphorylation of STAT3 in a Dose- and Time-dependent Manner

Evidence Based Analysis of Cisplatin for Treating Patients with Cutaneous Squamous Cell Carcinoma

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