AtGIS, a C2H2 zinc-finger transcription factor from Arabidopsis regulates glandular trichome development through GA signaling in tobacco

Liu, Yihua; Liu, Dongdong; Hu, Rui; Hua, Changmei; Ali, Imran; Zhang, Aidong; Liu, Bohan; Wu, Minjie; Huang, Linli; Gan, Yinbo

doi:10.1016/j.bbrc.2016.12.164

Cited by 47 publications

(35 citation statements)

References 35 publications

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“…In this respect, some phytohormones, especially jasmonate (JA) and possibly GAs, elicit glandular trichome development via signaling cascades and the activation of trichome-specific transcriptional regulators (Li et al, 2004;Koo and Howe, 2009;Bose et al, 2013;Bosch et al, 2014;Tian et al, 2014;Liu et al, 2017;Yan et al, 2017). In Mentha arvensis, exogenous application of GA resulted in a moderate increase in trichome density and diameter of the gland, suggesting a positive, although moderate, effect of GA on trichome initiation and development in mint (Bose et al, 2013).…”

Section: A Detailed Understanding Of Glandular Trichome Initiation Anmentioning

confidence: 99%

“…Several transcription factors belonging to different protein families and playing a role in glandular trichome development have indeed been identified: AmMIXTA, a MYB transcription factor from A. majus whose ectopic expression in tobacco induces the development of additional long glandular trichomes (Glover et al, 1998); GoPGF, a basic helix-loop-helix (bHLH) transcription factor from Gossypium spp., acting as a positive regulator of glandular trichome formation, its silencing leading to a completely glandless phenotype (Ma et al, 2016); AaHD1, a homeodomain-Leu zipper transcription factor required for jasmonate-mediated glandular trichome initiation in A. annua ; AtGIS, a C2H2 zinc-finger transcription factor from Arabidopsis whose ectopic expression in tobacco regulates glandular trichome development through GA 3 signaling (Liu et al, 2017); AaMYB1, a MYB transcription factor from A. annua whose overexpression induces the formation of a greater number of trichomes (Matías-Hernández et al, 2017); and CsGL3, an HD-Zip Figure 1. Glandular trichome initiation and development, a process with many unknowns.…”

Section: A Detailed Understanding Of Glandular Trichome Initiation Anmentioning

confidence: 99%

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Plant Glandular Trichomes: Natural Cell Factories of High Biotechnological Interest

2017

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ORCID IDs: 0000-0001-9302-405X (A.H.); 0000-0002-2315-6900 (M.B.); 0000-0002-3688-7614 (C.H.).Multicellular glandular trichomes are epidermal outgrowths characterized by the presence of a head made of cells that have the ability to secrete or store large quantities of specialized metabolites. Our understanding of the transcriptional control of glandular trichome initiation and development is still in its infancy. This review points to some central questions that need to be addressed to better understand how such specialized cell structures arise from the plant protodermis. A key and unique feature of glandular trichomes is their ability to synthesize and secrete large amounts, relative to their size, of a limited number of metabolites. As such, they qualify as true cell factories, making them interesting targets for metabolic engineering. In this review, recent advances regarding terpene metabolic engineering are highlighted, with a special focus on tobacco (Nicotiana tabacum). In particular, the choice of transcriptional promoters to drive transgene expression and the best ways to sink existing pools of terpene precursors are discussed. The bioavailability of existing pools of natural precursor molecules is a key parameter and is controlled by so-called cross talk between different biosynthetic pathways. As highlighted in this review, the exact nature and extent of such cross talk are only partially understood at present. In the future, awareness of, and detailed knowledge on, the biology of plant glandular trichome development and metabolism will generate new leads to tap the largely unexploited potential of glandular trichomes in plant resistance to pests and lead to the improved production of specialized metabolites with high industrial or pharmacological value.

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Section: A Detailed Understanding Of Glandular Trichome Initiation Anmentioning

confidence: 99%

Section: A Detailed Understanding Of Glandular Trichome Initiation Anmentioning

confidence: 99%

Plant Glandular Trichomes: Natural Cell Factories of High Biotechnological Interest

2017

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“…Salt stress leads to the accumulation of reactive oxygen species (ROS), which are toxic to plant cells. C2H2 zinc finger proteins can regulate expression of genes associated with ROS scavenging to reduce the accumulation of H 2 O 2 under salt stress (Liu et al ).…”

Section: Introductionmentioning

confidence: 99%

The role of C2H2 zinc finger proteins in plant responses to abiotic stresses

Wang

Ding

Cai

et al. 2018

Physiologia Plantarum

127

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Abiotic stresses are important factors affecting plant growth and development and limiting agricultural production worldwide. Plants have evolved complex regulatory mechanisms to respond and adapt to constantly changing environmental conditions. C2H2 zinc finger proteins form a relatively large family of transcriptional regulators in plants. Recent studies have revealed that C2H2 zinc finger proteins function as key transcriptional regulators in plant responses to a wide spectrum of stress conditions, including extreme temperatures, salinity, drought, oxidative stress, excessive light and silique shattering. Here, we summarize recent functional analysis on C2H2 zinc finger proteins in plant responses to abiotic stresses and discuss their roles as part of a large regulatory network in the perception and responses by plants to different environmental stimuli.

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“…Nevertheless, Arabidopsis contains a single type of unicellular, nonglandular trichome, and our understanding of the molecular mechanism of regulation of glandular trichome development is still relatively limited. Over the past decades, several TF families and genes controlling the glandular trichome formation has been well characterized in other plant species such as a MYB-related TF (MIXTA) from Antirrhinum majus; its ectopic expression leads to excess numbers of multicellular glandular trichomes in tobacco [15]; in cucumber, three HD-Zip TFs, namely CsGL1, CsGL2, and CsGL3 are required for glandular trichomes formation [16][17][18]; GoPGF, which encodes a basic helix-loop-helix domain-containing TF is involved as positive regulator of glandular trichome formation in cotton [19]; The Arabidopsis AtGIS, a C2H2 zinc-finger TF overexpression in tobacco regulates the glandular trichome development through GA signaling pathway [20]. In contrast to other plant species, the molecular mechanisms and regulatory genes which regulate glandular trichome development and density are currently unknown in the hop.…”

Section: Introductionmentioning

confidence: 99%

Dissection of Dynamic Transcriptome Landscape of Leaf, Bract, and Lupulin Gland in Hop (Humulus lupulus L.)

Mishra

Kocábek

Nath

et al. 2019

IJMS

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The hop plant (Humulus lupulus L.) produces several valuable secondary metabolites, such as prenylflavonoid, bitter acids, and essential oils. These compounds are biosynthesized in glandular trichomes (lupulin glands) endowed with pharmacological properties and widely implicated in the beer brewing industry. The present study is an attempt to generate exhaustive information of transcriptome dynamics and gene regulatory mechanisms involved in biosynthesis and regulation of these compounds, developmental changes including trichome development at three development stages, namely leaf, bract, and mature lupulin glands. Using high-throughput RNA-Seq technology, a total of 61.13, 50.01, and 20.18 Mb clean reads in the leaf, bract, and lupulin gland libraries, respectively, were obtained and assembled into 43,550 unigenes. The putative functions were assigned to 30,996 transcripts (71.17%) based on basic local alignment search tool similarity searches against public sequence databases, including GO, KEGG, NR, and COG families, which indicated that genes are principally involved in fundamental cellular and molecular functions, and biosynthesis of secondary metabolites. The expression levels of all unigenes were analyzed in leaf, bract, and lupulin glands tissues of hop. The expression profile of transcript encoding enzymes of BCAA metabolism, MEP, and shikimate pathway was most up-regulated in lupulin glands compared with leaves and bracts. Similarly, the expression levels of the transcription factors and structural genes that directly encode enzymes involved in xanthohumol, bitter acids, and terpenoids biosynthesis pathway were found to be significantly enhanced in lupulin glands, suggesting that production of these metabolites increases after the leaf development. In addition, numerous genes involved in primary metabolism, lipid metabolism, photosynthesis, generation of precursor metabolites/energy, protein modification, transporter activity, and cell wall component biogenesis were differentially regulated in three developmental stages, suggesting their involvement in the dynamics of the lupulin gland development. The identification of differentially regulated trichome-related genes provided a new foundation for molecular research on trichome development and differentiation in hop. In conclusion, the reported results provide directions for future functional genomics studies for genetic engineering or molecular breeding for augmentation of secondary metabolite content in hop.

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AtGIS, a C2H2 zinc-finger transcription factor from Arabidopsis regulates glandular trichome development through GA signaling in tobacco

Cited by 47 publications

References 35 publications

Plant Glandular Trichomes: Natural Cell Factories of High Biotechnological Interest

Plant Glandular Trichomes: Natural Cell Factories of High Biotechnological Interest

The role of C2H2 zinc finger proteins in plant responses to abiotic stresses

Dissection of Dynamic Transcriptome Landscape of Leaf, Bract, and Lupulin Gland in Hop (Humulus lupulus L.)

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