2013
DOI: 10.1016/j.clinbiochem.2013.03.023
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Atherogenic lipid profile and high sensitive C-reactive protein in patients with rheumatoid arthritis

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Cited by 20 publications
(18 citation statements)
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“…Rheumatoid arthritis is an incapacitating progressive articular disease that needs close monitoring and early detection of the disease activity for the early therapeutic intrusion to avoid joint damage. 1 , 16 Increased CRP, fibrinogen, and ferritin as acute phase reactants is a prominent feature of autoimmune diseases such as RA which reflects the inflammatory state and complements activation mediated by pro-inflammatory interleukins notably, IL-6, thus resulting in joint damage and progressive radiological findings. 17 …”
Section: Discussionmentioning
confidence: 99%
“…Rheumatoid arthritis is an incapacitating progressive articular disease that needs close monitoring and early detection of the disease activity for the early therapeutic intrusion to avoid joint damage. 1 , 16 Increased CRP, fibrinogen, and ferritin as acute phase reactants is a prominent feature of autoimmune diseases such as RA which reflects the inflammatory state and complements activation mediated by pro-inflammatory interleukins notably, IL-6, thus resulting in joint damage and progressive radiological findings. 17 …”
Section: Discussionmentioning
confidence: 99%
“…In the present study, we reported that RA patients with high levels of anti-CCP antibodies have a poor clinical prognosis and subclinical cardiovascular risk, based on increased cIMT, CRP, and high levels of proinflammatory molecules such as TNF α and IL-6. Serum TNF α and IL-6 were strongly correlated with cIMT ( Table 3 ) [ 44 ]. Furthermore, the anti-CCP positive patients had a more atherogenic lipid profile characterized by lower HDL-c and a high AIP ( Table 2 ).…”
Section: Discussionmentioning
confidence: 99%
“…Various measures are used for the evaluation of disease activity in rheumatoid arthritis and laboratory tests such as ESR and CRP are being used as markers of inflammation [2]. CRP is an acute phase protein synthesized by hepatocytes in response to stimulation by proinflammatory cytokines, particularly IL-6 [3]. Although a general marker of systemic inflammation, CRP has been established as a promising inflammatory marker in RA [4] and measurement of serum CRP concentration as a measure of disease activity is being practiced since a long time.…”
Section: Introductionmentioning
confidence: 99%