Atherosclerosis and Thrombosis

MRI is well suited for imaging vascular disease as it provides excellent soft tissue contrast and spatial resolution of the vessel wall. By generating potent contrast effects, iron oxide particles further enhance the ability of MRI to deliver functional information in a range of vascular syndromes. Larger microparticles of iron oxide (MPIO) generate sufficient contrast to enable detection of low-abundance vascular targets in vivo. Ligand-conjugated MPIO confer molecular specificity, facilitating molecular imaging of a range of specific endovascular targets. This review discusses the application of iron oxide particles in the molecular imaging of a variety of vascular syndromes. In particular, ligand-conjugated MPIO have been used for targeted molecular imaging in experimental models of atherosclerosis, thrombosis, and tissue ischemia syndromes. This provides a platform for vascular molecular imaging that could accelerate diagnosis, characterize disease progression, and measure response to treatment in a clinical setting.

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Microparticle-Based Molecular MRI of Atherosclerosis, Thrombosis, and Tissue Ischemia

Mankia

McAteer

Choudhury

2010

Curr Cardiovasc Imaging Rep

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An approach to molecular imaging of atherosclerosis, thrombosis, and vascular inflammation using microparticles of iron oxide

et al. 2010

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The rapidly evolving field of molecular imaging promises important advances in the diagnosis, characterization and pharmacological treatment of vascular disease. Magnetic resonance imaging (MRI) provides a modality that is well suited to vascular imaging as it can provide anatomical, structural and functional data on the arterial wall. Its capabilities are further enhanced by the use of a range of increasingly sophisticated contrast agents that target specific molecules, cells and biological processes. This article will discuss one such approach, using microparticles of iron oxide (MPIO).MPIO have been shown to create highly conspicuous contrast effects on T2*-weighted MR images. We have developed a range of novel ligand-conjugated MPIO for molecular MRI of endothelial adhesion molecules, such as vascular cell adhesion molecule-1 (VCAM-1) and P-selectin expressed in vascular inflammation, as well as activated platelet thrombosis. This review discusses the application of ligand-targeted MPIO for in vivo molecular MRI in a diverse range of vascular disease models including acute vascular inflammation, atherosclerosis, thrombosis, ischemia-reperfusion injury and ischemic stroke. The exceptionally conspicuous contrast effects of ligand-conjugated MPIO provide a versatile and sensitive tool for quantitative vascular molecular imaging that could refine diagnosis and measure response to treatment. The potential for clinical translation of this new class of molecular contrast agent for clinical imaging of vascular syndromes is discussed.

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Assessment of Glucocorticoids ‒ Induced Preclinical Atherosclerosis

Amin¹,

Nawito²

2012

Glucocorticoids - New Recognition of Our Familiar Friend

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Atherosclerosis and Thrombosis

Cited by 3 publications

References 102 publications

Microparticle-Based Molecular MRI of Atherosclerosis, Thrombosis, and Tissue Ischemia

Microparticle-Based Molecular MRI of Atherosclerosis, Thrombosis, and Tissue Ischemia

An approach to molecular imaging of atherosclerosis, thrombosis, and vascular inflammation using microparticles of iron oxide

Assessment of Glucocorticoids ‒ Induced Preclinical Atherosclerosis

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