Atherosclerosis Prediction with High Sensitivity C-Reactive Protein (hs-CRP) and Related Risk Factor in Patient with Dyslipidemia

Swastini, Dewa Ayu; Wiryanthini, Ida Ayu Dewi; Ariastuti, Ni Luh Putu; Muliantara, Agus

doi:10.3889/oamjms.2019.526

Cited by 45 publications

(31 citation statements)

References 17 publications

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“… 24 Several studies have reported that inflammation is involved in all stages of AS formation, including early AS, plaque instability, thrombosis, and cardiovascular events. 25 CRP, a nonspecific marker of inflammation, is a strong predictor of future cardiovascular events. 26 In the present study, we found that the patient’s CRP concentration was significantly increased, which is consistent with the results of existing studies.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic and Prognostic Significance of miR-675-3p in Patients With Atherosclerosis

Wang

Shao

Gao

et al. 2021

Clin Appl Thromb Hemost

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In recent years, a rising number of studies have confirmed that microRNA (miRNA) plays a prominent role in the early diagnosis and prognostic value assessment of cardiovascular diseases. The current study was conducted to examine the expression of miR-675-3p in atherosclerosis (AS) patients and to evaluate its clinical diagnosis and prognostic value. 110 AS patients and 70 healthy controls were included in the study. Serum miR-675-3p levels were detected by quantitative real-time PCR (qRT-PCR). The clinical diagnostic significance of serum miR-675-3p in AS patients were investigated by the receiver operating characteristic (ROC) curve. The correlation between miRNA and carotid intima-media thickness (CIMT) was analyzed by the Spearman correlation coefficient. The prognostic significance of serum miR-675-3p was evaluated by the Kaplan-Meier method and Cox regression analysis. The patient’s serum miR-675-3p was significantly increased than the healthy individuals ( P < 0.05). An increase of carotid intima-media thickness (CIMT) was positively correlated with the promotion of serum miR-675-3p levels. The area under the ROC curve (AUC) was 0.918, with high sensitivity and specificity. miR-675-3p is a key independent predictor of cardiovascular adverse events in AS patients (HR = 5.375, 95%CI = 1.590-18.170, P = 0.007), and patients with elevated miR-675-3p were more likely to have cardiovascular adverse events (log-rank P = 0.030). Increased miR-675-3p can be used as a potential marker for the diagnosis of AS, and was associated with the poor prognosis of AS.

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Section: Discussionmentioning

confidence: 99%

Diagnostic and Prognostic Significance of miR-675-3p in Patients With Atherosclerosis

Wang

Shao

Gao

et al. 2021

Clin Appl Thromb Hemost

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“…It explains that elevated serum UA ratio in dialysis patients was lower than non-dialysis CKD ones. As for serum UA, an increase of serum hs-CRP was reported in PD patients [ 7 - 10 ]. Fine [ 32 ] found 31% of PD patients with increasing serum CRP.…”

Section: Discussionmentioning

confidence: 99%

“…C-reactive protein (CRP) is synthesized mainly in the liver and released into the bloodstream in response to an acute phase of tissue damage or infection. Many studies have also shown that some factors such as for overweight, elderly, hypertension, diabetes, smoking, and other cardiovascular risks also affect hs-CRP levels [7][8][9][10]. In PD patients, elevated hs-CRP levels are related to higher cardiovascular events and mortality [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

High Serum Uric Acid and High-Sensitivity C Reactive Protein Concentrations Predict Three-Year Cardiovascular Mortality in Patients Treated With Continuous Ambulatory Peritoneal Dialysis

Quy

Huy

Minh

et al. 2021

Cureus

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Aims: This study aims to access the predicting value of serum uric acid (UA) and high-sensitivity C reactive protein (hs-CRP) concentration on three-year cardiovascular-related mortality in patients performing continuous ambulatory peritoneal dialysis (CAPD). Methods: A total of267 CAPD patients [150 male (56.2%); mean age 48.93 ± 13.58 years] were included in our study. All patients had measured serum UA and hs-CRP concentration. A high-sensitivity particle-enhanced immunoturbidimetric assay determined serum hs-CRP; serum UA levels were determined using an enzymatic colorimetric assay. All patients were followed for three years to detect cardiovascular-related mortality by cardiologists and stroke specialists. Results: Mean serum UA level was 415.16 ± 84.28 µmol/L, 58.4% of patients had increased serum UA level. Median serum hs-CRP level was 2 (1-4) mg/L, 12.4% of patients had increased serum hs-CRP level. During 36 months of follow-up, 41 patients (15.4%) had cardiovascular-related mortality. The results of Cox proportional hazards regression showed that hypertension, diabetes, high serum UA and hs-CRP were risk factors that related to cardiovascular-related mortality (p<0.05). The receiver operating characteristic (ROC) curve and Kaplan-Meier analysis results showed that UA and hs-CRP level had predictive value for three-year cardiovascular-related mortality in CAPD patients [uric acid: area under the curve (AUC)=0.822; hs-CRP: AUC=0.834, p < 0.001]. Conclusion: High serum UA and hs-CRP levels were predictive factors of cardiovascular-related mortality in CAPD patients.

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“…Amyloid A (AA) as an indicator of inflammatory response plays a key role in acute and chronic inflammatory response [ 14 ], and atherosclerosis is a chronic inflammatory response related to increased expression of AA in humans [ 15 ]. High-sensitivity C-reactive protein (hs-CRP) is a marker of systemic inflammatory response and inflammatory response plays an important role in atherosclerosis initiation and progression [ 16 ]. The pathogenic activity of proinflammatory cytokine tumor necrosis factor- α (TNF- α ) promotes inflammatory response and plays a pivotal role in the progression of in atherosclerostic cardiovascular diseases [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Oxidative Stress and Inflammation Are Associated with Coexistent Severe Multivessel Coronary Artery Stenosis and Right Carotid Artery Severe Stenosis in Elderly Patients

Guo

et al. 2021

Oxidative Medicine and Cellular Longevity

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Oxidative stress and inflammatory response are the main pathogenic pathways in atherosclerosis stenosis. This study is aimed at evaluating the roles of oxidative stress and inflammatory response in coexistent right carotid artery severe stenosis and severe multivessel coronary artery stenosis in elderly patients. Circulating levels of total oxidant status (TOS), lipid hydroperoxide (LHP), 8-isoprostane (8-IP), malondialdehyde (MDA), monocyte chemotactic protein-4 (MCP-4), amyloid A (AA), high-sensitivity C-reactive protein (hs-CRP), and tumor necrosis factor-α (TNF-α) were measured by standardised laboratory test methods. Markers of oxidative stress and inflammatory response: levels of TOS, LHP, 8-IP, MDA, MCP-4, AA, hs-CRP, and TNF-α, were increased ( P < 0.001 ) in elderly patient. These results suggested that oxidative stress and inflammatory response may be involved in carotid artery severe stenosis and severe multivessel coronary artery stenosis and measuring oxidative stress and inflammation biomarkers may also be a promising step in the development of an effective method for monitoring the severity of right carotid artery stenosis and multivessel coronary artery stenosis in elderly patients.

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Atherosclerosis Prediction with High Sensitivity C-Reactive Protein (hs-CRP) and Related Risk Factor in Patient with Dyslipidemia

Cited by 45 publications

References 17 publications

Diagnostic and Prognostic Significance of miR-675-3p in Patients With Atherosclerosis

Diagnostic and Prognostic Significance of miR-675-3p in Patients With Atherosclerosis

High Serum Uric Acid and High-Sensitivity C Reactive Protein Concentrations Predict Three-Year Cardiovascular Mortality in Patients Treated With Continuous Ambulatory Peritoneal Dialysis

Oxidative Stress and Inflammation Are Associated with Coexistent Severe Multivessel Coronary Artery Stenosis and Right Carotid Artery Severe Stenosis in Elderly Patients

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