Atherothrombotic Disorders

Hypercoagulable States in Cardiovascular Disease

“…In some cases, familial clustering and genetic influences are discernible 52 (Figure 3). Pregnancy, estrogen intake, smoking, 53 and, more recently, fine particulate air pollution can cause profound changes in coagulation. 54 Consumption of a triglyceride-rich meal is associated with an acute elevation of factor VIIa, 55 although it remains uncertain whether this increase depends on the actual fatty acid composition of ingested triglycerides.…”

“…53 This is because common atherosclerotic risk factors themselves, particularly diabetes mellitus or the metabolic syndrome, are potent mediators of thrombosis, stimulating the production of procoagulant proteins and/or impairing fibrinolysis. 89 The presence of numerous procoagulant proteins within atheromatous plaques provides further evidence for the involvement of the hemostatic system in atherosclerosis.…”

An uncommon myocardial infarction

“…Myeloproliferative disorders particularly polycythemia vera or essential thrombocythemia are well known atypical risk factors for coronary thrombosis [11], as well as the antiphospholipid syndrome, Factor V Leiden mutation and Prothrombin mutation G20210A [12]. These disorders should be screened in all young patients (male and female younger than 55 and 60 years, respectively) with myocardial infarction not explained by coronary atherosclerosis or other apparent cause [11].…”

Increased Plasma Level of D-Dimer as a Marker of High Arterial Thrombosis Risk

“…При атеросклерозе и ИБС происходит формирова-ние внутрисосудистых тромбов; поэтому очень часто у больных ИБС отмечается повышенный уровень факторов свертывания крови (протромбин, фибриноген, vWF, ак-тиватор плазминогена) [26]. В то же время при усло-вии нормального функционирования фибринолити-ческой системы постоянно должны происходить и процессы разрушения фибрина и образования фраг-ментов фибрин-полимера.…”