2015
DOI: 10.1590/1983-084x/13_054
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Atividade gastroprotetora do extrato etanólico de Pavonia alnifolia A.St.-Hil.

Abstract: RESUMO:No Brasil, a família Malvaceae está representada por aproximadamente 200 espécies e algumas foram descritas como gastroproteroras. Pavonia alnifolia A.St.-Hil. (Malvaceae) foi selecionada após uma abordagem quimiossistemática, considerando-se sua potencial capacidade em prevenir lesões gástricas. Assim, a atividade gastroprotetora do extrato etanólico de caules de P. alnifolia foi avaliada utilizando o modelo de indução aguda da lesão gástrica por etanol acidificado em camundongos. Além disso, foram qua… Show more

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Cited by 4 publications
(1 citation statement)
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“…With respect to acidi ed ethanol, HCl gives a more aggressive power to ethanol, it in ltrates instantaneously in the gastric mucosa and causes lesions to the membrane, leading to cell exfoliation, erosion and the appearance of ulcers, in which the mechanism of ulcer induction occurs by reactive oxygen species (Ewald et al 2015). We can observe that hecogenin acetate was able to reduce the injury, having an anti-ulcerogenic effect, in the experimental model of absolute ethanol and acidi ed ethanol in a signi cant way when compared to the vehicle.…”
Section: Discussionmentioning
confidence: 99%
“…With respect to acidi ed ethanol, HCl gives a more aggressive power to ethanol, it in ltrates instantaneously in the gastric mucosa and causes lesions to the membrane, leading to cell exfoliation, erosion and the appearance of ulcers, in which the mechanism of ulcer induction occurs by reactive oxygen species (Ewald et al 2015). We can observe that hecogenin acetate was able to reduce the injury, having an anti-ulcerogenic effect, in the experimental model of absolute ethanol and acidi ed ethanol in a signi cant way when compared to the vehicle.…”
Section: Discussionmentioning
confidence: 99%