Atkins diet program rapidly decreases atherogenic index of plasma in trained adapted overweight men

Caminhotto, Rennan de Oliveira; Fonseca, Felipe Lucas Tavares da; Castro, Natalie Carolina de; Arantes, João Pedro; Sertié, Rogério Antônio Laurato

doi:10.1590/2359-3997000000106

Cited by 14 publications

(10 citation statements)

References 21 publications

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“…These findings were parallel with the results of the previous studies. [7][8][9][10][11][12][13]26,27 We additionally found that these lipid levels and atherogenic indices did not differ in lower-or higher-risk groups for exacerbation. Additionally, epidemiological data showed a strong relationship between air-flow limitation and cardiovascular disease.…”

Section: Discussionmentioning

confidence: 93%

“…In the past decade, in addition to classical atherogenic risk factors, it was described that increases in some lipid ratios called atherogenic indices yield advantages in identifying some individuals with chronic diseases at higher risk of developing cardiovascular disease. [7][8][9][10][11][12][13][14][15]25 To our knowledge, although atherogenic indices were studied to predict cardiovascular disease in some diseases, including diabetes mellitus, metabolic syndrome, systemic hypertension, familial Mediterranean fever, pregnancy-induced hy- pertension, psychiatric diseases, and others, its role in COPD had not been studied. [7][8][9][10][11][12][13]26,27 In the present study, we evaluated and compared atherogenic indices (atherogenic index of plasma, cardiogenic risk ratio, and atherogenic coefficient) in addition to the serum lipid parameters in subjects with COPD and in control subjects.…”

Section: Discussionmentioning

confidence: 99%

“…Several algorithms have been established for early prediction of the presence of cardiovascular risk factors or atherosclerosis in the literature. [7][8][9][10][11][12] For these prediction algorithms, several lipoprotein ratios or atherogenic indices (atherogenic index of plasma, cardiogenic risk ratio, and atherogenic coefficient) have been defined and investigated in several diseases. 7,9,13,14 To the best of our knowledge, there is no study investigating the association between atherogenic indices in subjects with COPD in the current literature.…”

Section: Introductionmentioning

confidence: 99%

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New Predictor of Atherosclerosis in Subjects With COPD: Atherogenic Indices

2016

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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New Predictor of Atherosclerosis in Subjects With COPD: Atherogenic Indices

2016

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“…29 The uric acid level was significantly elevated by LCD, and the elevated degree was significantly correlated with HbA1c. From our clinical experience with the LCD diet in thousands of patients, the changes in uric acid levels ran the gamut from increase, stabilization and decrease.…”

mentioning

confidence: 89%

Effect of Low Carbohydrate Diet on Type 2 Diabetic Patients and Usefulness of M-Value

Bando¹,

Ebe²,

Muneta³

et al. 2017

Diabetes Res Open J

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Background: Debate between the Calorie Restriction (CR) and Low-Carbohydrate Diet (LCD) has been continued for several years. We have started LCD therapy for diabetic patients since 1999, and experienced good response to control hyperglycemia. Recently the risk of postprandial hyperglycemia for cardiovascular events is reported, and the range of glucose level is focused. Morbus (M) value is proposed to be a good index to show the range of glucose fluctuation. Usefulness of LCD and usefulness of M-value were shown by combined analysis. Methods: Twenty-six patients with Type 2 Diabetes Mellitus (T2DM), who admitted to the Takao Hospital, were the subjects. They were 12 males and 14 females, and their age ranged from 38 to 78 years old. A few patients were new patients, but mostly referred from other hospitals to receive LCD treatment. All patients started from CR therapy with 60% carbohydrate for 2 days, and then carried out LCD dietary therapy with 12% carbohydrates for 10-12 days. On day 2 and 12, blood glucose level was measured at 7 points a day to see the fluctuation from morning to night. Blood and urinary samples were corrected on the same day to get ordinary biochemical data and metabolic marker. Results: To know the effect of LCD on different level of HbA1c, the patients were grouped to low (L; 6.1±0.5%), middle (M; 7.9±0.4%) and high (H; 9.2±0.7%) by HbA1c value. The M-values after 2 day CR were 26.1 (L), 94.1 (M) and 343 (H), respectively. The LCD therapy decreased M-value to 10.4 (L), 18.8 (M) and 84.2 (H), respectively. The significant reduction of M-values was a reflection of the improved postprandial glucose level. LCD was effective even in the bad controlled diabetic patients. In addition to the decreased triacylglycerol and 24 hr urinary C-peptide, uric acid increased in all patients. Conclusion: Ten to 12 day-dietary therapy with LCD was quite effective to improve blood glucose profile. Patients with high HbA1c could be safely treated by LCD. Blood glucose improvement was well correlated to the M-value.

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“…One of the dietary approaches that has attracted particular success in recent years is the “ketogenic diet” (KD). This is a dietary program that was designed in the 1920s as a therapy for drug-resistant epilepsy [ 1 , 2 ], which then gained popularity in the 1970s as a weight-loss diet (Atkins) [ 3 , 4 ]. Currently, there are many diets that are based on this model.…”

Section: Introductionmentioning

confidence: 99%

Metabolic Responses in Endothelial Cells Following Exposure to Ketone Bodies

et al. 2018

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The ketogenic diet (KD) is a high-fat, low-carbohydrate diet based on the induction of the synthesis of ketone bodies (KB). Despite its widespread use, the systemic impact of KD is not completely understood. The purpose of this study was to evaluate the effects of physiological levels of KB on HMEC-1 endothelial cells. To this aim, DNA oxidative damage and the activation of Nrf2, a known transcriptional factor involved in cell responses to oxidative stress, were assessed. The exposure of cells to KB exerted a moderate genotoxic effect, measured by a significant increase in DNA oxidative damage. However, cells pre-treated with KB for 48 h and subjected to a secondary oxidative insult (H2O2), significantly decreased DNA damage compared to control oxidized cells. This protection occurred by the activation of Nrf2 pathway. In KB-treated cells, we found increased levels of Nrf2 in nuclear extracts and higher gene expression of HO-1, a target gene of Nrf2, compared to control cells. These results suggest that KB, by inducing moderate oxidative stress, activate the transcription factor Nrf2, which induces the transcription of target genes involved in the cellular antioxidant defense system.

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Atkins diet program rapidly decreases atherogenic index of plasma in trained adapted overweight men

Cited by 14 publications

References 21 publications

New Predictor of Atherosclerosis in Subjects With COPD: Atherogenic Indices

New Predictor of Atherosclerosis in Subjects With COPD: Atherogenic Indices

Effect of Low Carbohydrate Diet on Type 2 Diabetic Patients and Usefulness of M-Value

Metabolic Responses in Endothelial Cells Following Exposure to Ketone Bodies

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