Atmospheric Pressure Variation is a Delayed Trigger for Aneurysmal Subarachnoid Hemorrhage

Donkelaar, Carlina E. van; Potgieser, Adriaan R E; Groen, Henk; Foumani, Mahrouz; Abdulrahman, Hanna; Sluijter, R.J.; Dijk, J. Marc C. van; Groen, Rob J M

doi:10.1016/j.wneu.2018.01.155

Cited by 17 publications

(19 citation statements)

References 31 publications

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“…During wintertime, in the Baltic Sea region, a positive NAOI was associated with a higher T and with altered weather: a higher WS, a lower AP, and a north-eastward shift in the Atlantic storm activity with enhanced activity from Newfoundland into Northern Europe [25] As a positive NAO during the winter was associated with more changing weather, a positive NAO was risky for HS, whereas a change in T was more relevant for IS. Studies in Northern and Middle Europe have shown a higher risk of HS associated with changing weather but not with T [19,20,22,38]. A study conducted in the UK showed a signi cant impact of changes in T only on IS, whereas changes in AP had a signi cant impact only on the risk of HS [58].…”

Section: Discussionmentioning

confidence: 97%

“…Other researchers presented the explanations of this effect. Donkelaar et al [22] hypothesized that AP changes trigger the in ammation process in the aneurysm wall. Variations in AP may in uence on vessel walls and their endothelial function by endogenous in ammatory mechanisms [21].…”

Section: Discussionmentioning

confidence: 99%

“…Sunlight exposure has been shown to alter blood pressure through the effects of UV light on vitamin D [64]. The lack of vitamin D may induce an in ammatory process in the aneurysm wall that increases the risk of rupture [22]. Studies on the associations between physical activity in the elderly and weather conditions in Europe showed that physical activity decreased with increasing WS, precipitation, humidity, and a shorter duration of sunshine [65,66].…”

Section: Discussionmentioning

confidence: 99%

“…Studies have shown both a negative association [1,12,18] and a positive association [14,15,19] between the risk of stroke and AP. Studies conducted predominantly in Europe have shown an increase in the incidence of stroke associated with AP changes, adjusting for T or seasonality [19][20][21][22]. According to the study conducted in Germany, rapid decreases in ambient temperature and rapid changes in relative humidity and AP increase the risk of IS under temperate climate conditions [23].…”

Section: Introductionmentioning

confidence: 99%

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Association Between Stroke Occurrence and Changes in Atmospheric Circulation

Venclovienė

Radišauskas

Krančiukaitė-Butylkinienė

et al. 2020

Preprint

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Abstract Background: The impact of weather on morbidity from stroke was analysed in previous studies. As the risk of stroke was mostly associated with changing weather, the changes in the daily number of strokes may be associated with global changes in atmospheric circulation. The aim of our study was to detect and evaluate the association between daily numbers of ischaemic stroke (IS) and haemorrhagic stroke (HS) and the teleconnection pattern. Methods: The study was conducted in Kaunas city, Lithuania, from 2000 to 2010. The daily numbers of IS, subarachnoid haemorrhages (SAH), and intracerebral haemorrhages (ICH) were obtained from Kaunas Stroke Register. We evaluated the association between these types of stroke and the teleconnection pattern by applying Poisson regression, adjusting for the linear trend, month, and other weather variables. Results: During the study period, we analysed 4,038 cases (2,226 men and 1,812 women) of stroke. Of these, 3,245 (80.4%) cases were IS, 533 (13.2%) cases were ICH, and 260 (6.4%) cases were SAH. A change in mean daily atmospheric pressure of >3.9 hPa was associated with the risk of SAH (RR=1.49, 95% CI 1.14-1.96), and a stronger El Niño event had a protective effect against SAH (RR=0.34, 95% CI 0.16-0.69). The risk of HS was positively associated with East Atlantic/West Russia indices (RR=1.13, 95% CI 1.04-1.23). The risk of IS was negatively associated with Arctic Oscillation indices (RR=0.97, 95% CI 0.94-0.99). During November-March, a positive North Atlantic Oscillation (NAO) was associated with HS (RR=1.29, 95% CI 1.03-1.62), and a negative association between the NAO index and IS (RR=0.92, 95% CI 0.85-0.99) was found. Conclusions: The results of our study provided new evidence that the North Atlantic Oscillation, Arctic Oscillation, East Atlantic/West Russia, and El Niño-Southern Oscillation pattern may affect the risk of stroke. The impact of these teleconnection indices is not identical for different types of stroke. Emergency services should be aware of the fact that specific weather conditions are more likely to prompt calls for more severe strokes.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association Between Stroke Occurrence and Changes in Atmospheric Circulation

Venclovienė

Radišauskas

Krančiukaitė-Butylkinienė

et al. 2020

Preprint

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“…(c and F) Normal group, rabbits were untreated; (F) is an enlargement of (c). environmental factors (41)(42)(43)(44), little is known about its specific biological mechanisms. Genetic studies on IA have indicated that the onset of IA is associated with a few specific single nucleotide mutations, such as the tumor necrosis factor (TNF-α) gene (45), the interleukin (IL)-6 gene (46), the IL-12 gene (47), and the NADPH oxidase p22 phox gene (48,49), which suggests that there is a positive association between susceptibility genes and IA.…”

Section: Discussionmentioning

confidence: 99%

The active participation of p22phox-214T/C in the formation of intracranial aneurysm and the suppressive potential of edaravone

Luo

Wang

et al. 2018

Int J Mol Med

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Oxidative stress reactions play an important role in the pathogenesis of intracranial aneurysm (IA). p22phox is involved in the oxidative stress reaction, and it is a critical subunit of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase. The present study investigated the association of genetic variants within the gene encoding p22phox‑214T/C with IA. The p22phox‑214T/C gene polymorphisms in 192 cases of IA and 112 controls were analyzed by polymerase chain reaction‑restriction fragment length polymorphism (PCR‑RFLP). The mRNA expression of NADPH oxidase was also analyzed by RT‑PCR. The results of RT‑PCR were validated by ELISA. In a rabbit model of elastase‑induced aneurysm, we used edaravone for anti‑oxidative stress treatment to observe the curative effects. In the clinical cases, a significant difference in p22phox‑214T/C allele frequencies in the IA group was observed compared with the control group (P<0.001). The expression level of NADPH oxidase was differed significantly between the IA group and the control group. In the rabbit model of elastase‑induced aneurysm, the success rate of the aneurysmal model in the edaravone group and the wound ulcer rate were lower than those in the control group. In addition, the diameter of the aneurysm was smaller than in the edaravone group than in the control group (3.26±0.13 mm vs. 3.85±0.07 mm), and the expression of matrix metalloproteinase‑9 (MMP‑9) was significantly lower than that in the control group (P<0.0001). Thus, these data suggest the active participation of p22phox‑214T/C in the formation of IA and the suppressive potential of edaravone against IA formation.

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