Atom transfer radical polymerization (ATRP): A versatile and forceful tool for functional membranes

Jin, Ronghua; Wu, Liang; Zhang, Zhenghui; Xu, Tongwen

doi:10.1016/j.progpolymsci.2013.09.001

Cited by 183 publications

(88 citation statements)

References 165 publications

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“…silanization), polymer brushes can increase the spatial density of a diverse number of functional groups on a surface, thereby allowing the conjugation of a higher number of biomolecules (Figure 1). Moreover, these systems have been shown to be mechanically and chemically stable 38,39 . Based on these premises, the aim of the present study was to compare the efficiency of silanization and ATRP methods to immobilize the hLf1-11 peptide on titanium to develop surfaces with antimicrobial properties for dental applications.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Properties of hLf1–11 Peptide onto Titanium Surfaces: A Comparison Study Between Silanization and Surface Initiated Polymerization

et al. 2015

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Dental implant failure can be associated to infections which develop into periimplantitis. In order to reduce biofilm formation, several strategies focusing on the use of antimicrobial peptides (AMP) have been studied. To covalently immobilize these molecules onto metallic substrates several techniques have been developed, including silanization and polymer brush prepared by surface-initiated atom transfer radical polymerization (ATRP), with varied peptide binding yield and antibacterial performance. The aim of the present study was to compare the efficiency of these methods to immobilize the lactoferrin-derived hLf1-11 antibacterial peptide onto titanium, and evaluate their antibacterial activity in vitro.Smooth titanium samples were coated with hLf1-11 peptide under three different conditions: silanization with APTES, and polymer brush based coatings with two different silanes. Peptide presence was determined by X-ray photoelectron spectroscopy and the mechanical stability of the coatings was studied under ultrasonication. The LDH assays confirmed that HFFs viability and proliferation were no affected by the treatments. The in vitro antibacterial properties of the modified surfaces were tested with two oral strains (Streptococcus sanguinis and Lactobacillus salivarius) showing an outstanding reduction. A higher decrease in bacterial attachment was noticed when samples were modified by ATRP methods compared to silanization. This effect is likely due to the capacity to immobilize more peptide on the surfaces using polymer brushes and the non-fouling nature of polymer PDMA segment.3

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Section: Introductionmentioning

confidence: 99%

Antibacterial Properties of hLf1–11 Peptide onto Titanium Surfaces: A Comparison Study Between Silanization and Surface Initiated Polymerization

et al. 2015

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“…Atom transfer radical polymerization (ATRP) is proven to be one of the most versatile reversible deactivation radical polymerization (RDRP) methods that enables the preparation of polymers with controlled molecular weights (MWs), narrow molecular weight distributions (M w /M n , MWDs), and targeted degrees of polymerization (DP) [1][2][3][4][5][6][7][8][9][10][11][12][13]. The advent of low amount catalyst ATRP system, such as simplified electrochemically mediated ATRP (seATRP) [14] offers more environmentally friendly reaction conditions for the synthesis of polymers [15].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of cationic star polymers by simplified electrochemically mediated ATRP

Chmielarz¹

2016

Express Polym. Lett.

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Abstract. Cyclodextrin-based cationic star polymers were synthesized using β-cyclodextrin (β-CD) core, and 2-(dimethylamino)ethyl methacrylate (DMAEMA) as hydrophilic arms. Star-shaped polymers were prepared via a simplified electrochemically mediated ATRP (seATRP) under potentiostatic and galvanostatic conditions. The polymerization results showed molecular weight (MW) evolution close to theoretical values, and maintained narrow molecular weight distribution (MWD) of obtained stars. The rate of the polymerizations was controlled by applying more positive potential values thereby suppressing star-star coupling reactions. Successful chain extension of the ω-functional arms with a hydrophobic n-butyl acrylate (BA) formed star block copolymers and confirmed the living nature of the β-CD-PDMAEMA star polymers prepared by seATRP. Novelty of this work is that the β-CD-PDMAEMA-b-PBA cationic star block copolymers were synthesized for the first time via seATRP procedure, utilizing only 40 ppm of catalyst complex. The results from 1 H NMR spectral studies support the formation of cationic star (co)polymers.

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“…As is generally the case in controlled radical polymerization, ATRP chemistry relies on the equilibrium between active and dormant chains [46,47,55,56]. The mechanism is illustrated in Fig.…”

Section: Grafting Techniques 321 Atom Transfer Radical Polymerizatmentioning

confidence: 98%

PNIPAM grafted surfaces through ATRP and RAFT polymerization: Chemistry and bioadhesion

Conzatti

Cavalié

Combes

et al. 2017

Colloids and Surfaces B: Biointerfaces

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a b s t r a c tBiomaterials surface design is critical for the control of materials and biological system interactions. Being regulated by a layer of molecular dimensions, bioadhesion could be effectively tailored by polymer surface grafting. Basically, this surface modification can be controlled by radical polymerization, which is a useful tool for this purpose. The aim of this review is to provide a comprehensive overview of the role of surface characteristics on bioadhesion properties. We place a particular focus on biomaterials functionalized with a brush surface, on presentation of grafting techniques for "grafting to" and "grafting from" strategies and on brush characterization methods. Since atom transfer radical polymerization (ATRP) and reversible addition-fragmentation chain transfer (RAFT) polymerization are the most frequently used grafting techniques, their main characteristics will be explained. Through the example of poly(N-isopropylacrylamide) (PNIPAM) which is a widely used polymer allowing tuneable cell adhesion, smart surfaces involving PNIPAM will be presented with their main modern applications.

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Atom transfer radical polymerization (ATRP): A versatile and forceful tool for functional membranes

Cited by 183 publications

References 165 publications

Antibacterial Properties of hLf1–11 Peptide onto Titanium Surfaces: A Comparison Study Between Silanization and Surface Initiated Polymerization

Antibacterial Properties of hLf1–11 Peptide onto Titanium Surfaces: A Comparison Study Between Silanization and Surface Initiated Polymerization

Synthesis of cationic star polymers by simplified electrochemically mediated ATRP

PNIPAM grafted surfaces through ATRP and RAFT polymerization: Chemistry and bioadhesion

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