Atomic force microscopy and dark-toxicity pattern of unsymmetrical metallated porphyrins M(II)P-type as theranostics agents

Socoteanu, Radu; Anastasescu, Mihai; Boscencu, Rica; Constantin, Carolina; Neagu, Monica

doi:10.1016/j.mseb.2019.05.012

Cited by 1 publication

(3 citation statements)

References 28 publications

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“…We make no mistake to say that as the purpose of photodynamic therapy changes, the properties of Ps will also be modified. We are already able to observe current wide porphyrin integration in science and medicine (Figure ): Zn containing MeP are applied mostly in PDT, visualization, and theranostics; ,− ,− ,,,, Mn containing MeP are applied as effective contrast agents, radioprotectors, and components for catalyst therapy; − ,,,,,, Gd and Pt containing MeP are applied are used in PDT, MRI, and theranostics. ,,,,,− MePs have been integrated into various fields of medicine because they play a significant role in living organisms. Over the past few years, MeP development for visualization, protection and wound healing applications have received increased attention.…”

Section: Discussionmentioning

confidence: 99%

“…They synthesized complexes of symmetric 5-(4-hydroxy-3-methoxyphenyl)-10,15,20-tris(4-carboxymethylphenyl) porphyrins with Cu(II) and Zn(II) metals and revealed enhanced 1 O 2 quantum yield of ZnP over CuP. Using atomic force microscopy, it was found that MeP possess a morphology of aggregates suitable for cell adhesion. , …”

Section: Theranosticsmentioning

confidence: 99%

“…Using atomic force microscopy, it was found that MeP possess a morphology of aggregates suitable for cell adhesion. 262,263 Yang and colleagues synthesized a multifunctional theranostic agent targeted to mitochondria. The researchers designed Mn(II)P complex decorated with lipophilic triphenylphosphonium cation and transplatin, which accumulated specifically in mitochondria of cancer cells due to increased membrane potential.…”

Section: Theranosticsmentioning

confidence: 99%

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Metalloporphyrins in Medicine: From History to Recent Trends

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Nikolskaya

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ACS Appl. Bio Mater.

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The history of metalloporphyrins dates back more than 200 years ago. Metalloporphyrins are excellent catalysts, capable of forming supramolecular systems, participate in oxygen photosynthesis, transport, and used as contrast agents or superoxide dismutase mimetics. Today, metalloporphyrins represent complexes of conjugated π-electron system and metals from the entire periodic system. However, the effect of these compounds on living systems has not been fully understood, and researchers are exploring the properties of metalloporphyrins thereby extending their further application. This review provides an overview of the variety of metalloporphyrins that are currently used in different medicine fields and how metalloporphyrins became the subject of scientists’ interest. Currently, metalloporphyrins utilization has expanded significantly, which gave us an opprotunuty to summarize recent progress in metalloporphyrins derivatives and prospects of their application in the treatment and diagnosis of different diseases.

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