Atopic dermatitis as a systemic disease

Darlenski, Razvigor; Kazandjieva, Jana; Hristakieva, E.; Fluhr, Joachim W.

doi:10.1016/j.clindermatol.2013.11.007

Cited by 91 publications

(94 citation statements)

References 42 publications

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“…During the period prior to the first ASD diagnosis, asthma was diagnosed less often, and allergy and autoimmune disorders were diagnosed more often among children with ASD compared with TD children. Furthermore, prevalence estimates were reported for the whole pool of allergy in the ASD group versus the TD group, and resulted in 18 Another three studies assessed the association between AD and ASD on the basis of nationwide or populationbased survey study design.…”

Section: Association Between Asd and Ad In Connection With Other Atopmentioning

confidence: 99%

“…AD is a systemic chronic immunologic disorder with increased propensity toward inflammatory response [18].…”

Section: Immunological Pathwaymentioning

confidence: 99%

“…AD is linked to several comorbidities, such as food allergy (FA), infections, skin disorders, ocular disorders, idiopathic nephritic syndrome, autoimmune disorders, gastrointestinal (GI) disorders, and metabolic syndrome [18,25]. Furthermore, recent epidemiological studies have identified new comorbidities linked to AD, in particular several mental health conditions.…”

Section: Introductionmentioning

confidence: 99%

“…According to Darlenski et al [18], AD can be viewed as an organ-specific manifestation of a systemic disorder. Both immunological dysregulation and epidermal barrier defects concur as pathophysiologic mechanisms to the disease development.…”

Section: Introductionmentioning

confidence: 99%

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Association Between Atopic Dermatitis and Autism Spectrum Disorders: A Systematic Review

et al. 2015

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Overall, the results of this systematic review seem to reveal an association between ASD and AD, suggesting that subjects with ASD have an increased risk of presenting with AD compared with typically developing controls, and vice versa. This association is supported by clinical/epidemiological aspects, shared genetic background and common immunological and autoimmune processes. However, the variability in study population and design, and the presence of other risk factors acting as confounding factors, sometimes contribute to inconsistent results. Further studies are needed to clarify the underlying pathophysiologic mechanism explaining the association between ASD and AD and to explore the causal association between the two conditions.

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Section: Association Between Asd and Ad In Connection With Other Atopmentioning

confidence: 99%

“…AD is a systemic chronic immunologic disorder with increased propensity toward inflammatory response [18].…”

Section: Immunological Pathwaymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association Between Atopic Dermatitis and Autism Spectrum Disorders: A Systematic Review

et al. 2015

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“…It is known that the prevalence of AD is due to complex factors such as innate genetic problems and environmental triggers. Clinically, it is known that AD simultaneously triggers asthma and allergic rhinitis for which the levels of serum IgE and peripheral eosinophils are elevated; therefore, AD is defined as a systemic disorder [24].…”

Section: Summary Of Ad Associated Factors and Pathogenesismentioning

confidence: 99%

OMICS Integration Studies for New Insights on Atopic Dermatitis

Park¹

2014

CDT

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The number of Atopic Dermatitis (AD) patients has increased with modernization and industrialization, and AD patients and their family members experience severe quality of life issues. It is generally recognized that a combination of environmental factors such as allergens and bacterial infections, as well as genetic factors, are the principal inducers of the multiple immunologic and inflammatory responses seen in AD patients. In the present review article, we focused on the following primary issues from the broad category of AD disease that have been reported in research articles, including those by the authors' own research groups: i) AD types: characteristics of extrinsic and intrinsic types; ii) current treatments of AD and clinical applications; iii) new insights from OMICS integration studies for detecting hub genes; iv) summary of AD pathogenesis and associated factors; and v) further speculation for AD studies. The topics in this review that we focused on are expected to contribute to the understanding of AD disease-related factors. Since the mechanism of AD disease has been shown to be complex, our results may provide new clues to aid understanding of AD from the aspect of laboratorial OMICS applications.

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Persimmon leaf extract protects mice from atopic dermatitis by inhibiting T cell activation via regulation of the JNK pathway

Lee

Kim

et al. 2021

Phytotherapy Research

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Persimmon leaf extracts (PLE) have been widely used as a traditional medicine in East Asian countries. The effects of persimmon leaves, including antioxidant, antiinflammatory, hypotensive, and anti-allergy effects, have been investigated; however, there is little evidence on the inhibition of T cell activation in vitro and effects on T cell-related diseases, such as atopic dermatitis (AD), in vivo by persimmon leaves. PLE (50 μg/mL) effectively attenuated the mRNA levels of IL-2 in Jurkat T cells stimulated with PMA/A23187 and Staphylococcus enterotoxin E-loaded Raji B cells without causing cytotoxicity. In Jurkat T cells stimulated with PMA/A23187, treatment with 50 μg/mL PLE blocked the translocation of p65 and IκBα degradation. Moreover, the JNK signaling pathway in Jurkat T cells stimulated with PMA/A23187 was affected by treatment with PLE. The oral administration of PLE markedly attenuated AD manifestations in mice, including ear thickness, IgE levels, and lymph node sizes. These results indicate PLE significantly blocked T cell activation via NF-κB signaling and the JNK pathway. This suggests underlying mechanisms of PLE involving the control of effector cytokines produced by activated T cells in ear tissue and lymph nodes, as well as the infiltration of mast cells and the therapeutic potential of AD.

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Atopic dermatitis as a systemic disease

Cited by 91 publications

References 42 publications

Association Between Atopic Dermatitis and Autism Spectrum Disorders: A Systematic Review

Association Between Atopic Dermatitis and Autism Spectrum Disorders: A Systematic Review

OMICS Integration Studies for New Insights on Atopic Dermatitis

Persimmon leaf extract protects mice from atopic dermatitis by inhibiting T cell activation via regulation of the JNK pathway

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