2023
DOI: 10.3390/jcm12175534
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Atopic Dermatitis: Beyond the Skin and Into the Gut

Rachel L. Sadowsky,
Pranvera Sulejmani,
Peter A. Lio

Abstract: Atopic dermatitis (AD) is a common, chronic and recurring inflammatory skin disorder characterized by an intensely pruritic, eczematous dermatitis. The etiology of AD is thought to involve a combination of environmental, genetic, and immunologic factors. Emerging research has investigated factors that may impact individual risk for developing AD, disease severity, and treatment response. One component is the gut microbiome, which is considered to play an essential role in maintaining the homeostasis of several… Show more

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Cited by 6 publications
(2 citation statements)
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“…The precise pathogenesis of AD is not fully understood, but it is believed to be influenced by a combination of environmental and genetic factors, including hygiene, gut microbial diversity, pollution, climate, and diet [ 5 ]. The health and disease origin hypothesis proposes that the prenatal period plays a pivotal role in shaping the immune function of the fetus, with a potential increased risk of allergic diseases due to exposure to detrimental factors during this time [ 6 , 7 ].…”
Section: Introductionmentioning
confidence: 99%
“…The precise pathogenesis of AD is not fully understood, but it is believed to be influenced by a combination of environmental and genetic factors, including hygiene, gut microbial diversity, pollution, climate, and diet [ 5 ]. The health and disease origin hypothesis proposes that the prenatal period plays a pivotal role in shaping the immune function of the fetus, with a potential increased risk of allergic diseases due to exposure to detrimental factors during this time [ 6 , 7 ].…”
Section: Introductionmentioning
confidence: 99%
“…Актуальною проблемою в сучасній медичній практиці, у вирішенні якої психосоматичний підхід є провідним, вважаються розлади вегетативної регуляції. Проведений аналіз джерел наукової літератури з даного напряму пошуку вказав на широку зацікавленість як загальними питаннями психосоматичної медицини, так і причинами формування, проявами, діагностикою, лікуванням і можливими наслідками психосоматичних розладів при патології серцево-судинної системи [32][33][34][35], шлунково-кишкового тракту [36-38], органів дихання [39-41], залоз внутрішньої та зовнішньої секреції [42][43][44][45][46]. У той же час наукових досліджень щодо психосоматичних аспектів у нефрологічній практиці та дотичних фахових напрямах суттєво менше [47][48][49][50][51].…”
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