Atopic Dermatitis (Eczema)

Bershad, Susan

doi:10.7326/0003-4819-155-9-201111010-01005

Cited by 13 publications

(11 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…87 Notably, miRNAs upregulated in other allergic disorders, including miR-21, miR-146, and miR-223, are also upregulated in the skin of patients with atopic dermatitis. 42, 88 In addition, Sonkoly et al .…”

Section: Atopic Dermatitismentioning

confidence: 99%

Diagnostic, functional, and therapeutic roles of microRNA in allergic diseases

Rothenberg

2013

Journal of Allergy and Clinical Immunology

192

154

View full text Add to dashboard Cite

Allergic inflammation is accompanied by the coordinated expression of a myriad of genes and proteins that initiate, sustain, and propagate immune responses and tissue remodeling. MicroRNAs (miRNAs) are a class of short single-stranded RNA molecules that post-transcriptionally silence gene expression and have been shown to fine-tune gene transcriptional networks as single miRNAs can target hundreds of genes. 7 Considerable attention has focused on the key role of miRNAs in regulating homeostatic immune architecture and acquired immunity. Recent studies have identified miRNA profiles in multiple allergic inflammatory diseases including asthma, eosinophilic esophagitis, allergic rhinitis, and atopic dermatitis. Specific miRNAs have been found to have critical roles in regulating key pathogenic mechanisms in allergic inflammation including polarization of adaptive immune responses and activation of T cells (e.g. miR-21 and miR-146), regulation of eosinophil development (e.g. miR-21 and miR-223), and modulation of interleukin (IL)-13-driven epithelial responses (e.g. miR-375). This review discusses recent advances in our understanding of the expression and function of miRNAs in allergic inflammation, their role as disease biomarkers, and perspectives for future investigation and clinical utility.

show abstract

Section: Atopic Dermatitismentioning

confidence: 99%

Diagnostic, functional, and therapeutic roles of microRNA in allergic diseases

Rothenberg

2013

Journal of Allergy and Clinical Immunology

192

154

View full text Add to dashboard Cite

show abstract

“…Major allergic diseases are represented by asthma, atopic dermatitis and food allergy as recently reviewed (14)(15)(16) . Asthma is a chronic lung airway inflammation characterised by a Th-2 response with a robust production of IL-4, IL-5 and IL-13, which initiate and perpetuate the disease status (17) .…”

Section: Proceedings Of the Nutrition Societymentioning

confidence: 99%

Influence of polyphenols on allergic immune reactions: mechanisms of action

Magrone

Jirillo

2012

Proc. Nutr. Soc.

View full text Add to dashboard Cite

The increased incidence of allergic disease seems to rely on many factors. Among them, the association between genetic variations of the immune response and environmental pressure by allergens, infectious agents and pollutants should be taken into consideration. In alternative to conventional treatments with corticosteroids and antihistaminics, nutraceuticals have been shown to act on allergic disease either during allergic sensitisation or on consolidated disease. In this review, special emphasis is placed on the effects of dietary polyphenols on three major allergic diseases, namely atopic eczema, food allergy and asthma. Interference of polyphenols with T-helper 2 activation seems to be the main mechanism of their inhibitory effects on allergy development. Moreover, deficits of T-regulatory cells seem to play a pathogenic role in allergic disease and, therefore, these cells may represent a major target of polyphenol activity

show abstract

“…The disease is associated with abnormalities in skin barrier molecules and in cells of the inflammatory response. The immunoregulatory abnormalities are characterized by impaired Th1-Th2 cytokines balance, with a prevalent activation of Th2 cytokines, which results in increased serum immunoglobulin IgE and elevated total circulating eosinophil count [8]. …”

Section: Introductionmentioning

confidence: 99%

Probiotics and Atopic Dermatitis in Children

et al. 2012

View full text Add to dashboard Cite

There is increasing interest in the potential beneficial role of probiotic supplementation in the prevention and treatment of atopic diseases in children. Probiotics are defined as ingested live microorganisms that, when administered in an adequate amount, confer a health benefit to the host. They are mainly represented by Lactobacilli and Bifidobacteria. Several epidemiological data demonstrate that intestinal microflora of atopic children is different from the one of healthy children. Many literature data show that probiotics may modulate the intestinal microflora composition and may have immunomodulatory effect. Based on this hypothesis, probiotics are supposed to confer benefits to allergic diseases. Administration of probiotics when a natural population of indigenous intestinal bacteria is still developing could theoretically influence immune development by favoring the balance between Th1 and Th2 inflammatory responses. For this reason, some studies have evaluated the potential impact of probiotics supplementation in the prevention of atopic dermatitis, with contrasting results. Clinical improvement in immunoglobulin (Ig)E-sensitized (atopic) eczema following probiotic supplementation has been reported in some published studies and the therapeutic effects of probiotics on atopic dermatitis seemed to be encouraging. However, as far as the usefulness of probiotics as a prevention strategy is concerned, results are still inconclusive. In fact, the clinical benefits of probiotic therapy depend upon numerous factors, such as the type of bacteria, dosing regimen, delivery method and other underlying host factors, such as age and diet. More studies are still needed to definitively prove the role of probiotics in the treatment of allergic eczema.

show abstract

Atopic Dermatitis (Eczema)

Cited by 13 publications

References 0 publications

Diagnostic, functional, and therapeutic roles of microRNA in allergic diseases

Diagnostic, functional, and therapeutic roles of microRNA in allergic diseases

Influence of polyphenols on allergic immune reactions: mechanisms of action

Probiotics and Atopic Dermatitis in Children

Contact Info

Product

Resources

About