Atopic dermatitis; Etio-pathogenesis, An overview

Sehgal, Virendra; Khurana, Ananta; Mendiratta, Vibhu; Saxena, Deepti; Srivastava, Govind; Aggarwal, Ashok

doi:10.4103/0019-5154.160474

Cited by 10 publications

(5 citation statements)

References 52 publications

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“…Atopic dermatitis is a chronic or chronically relapsing hypersensitive manifestation of the skin with itching as a predominant feature. [12] . In this case also the child is having severe itching with exfoliation of the skin.…”

Section: Discussionmentioning

confidence: 99%

A Case Study on the Ayurvedic Management of Childhood Atopic Dermatitis

Lekshmi M K,

Thulasi A,

Nimmi K

2023

Int J Ayu Pharm Res

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Atopic Dermatitis (AD) is a chronic inflammatory skin condition with impaired cell-mediated immune function and compromised skin barrier. It is characterized by erythema, oedema, vesicles, oozing in the acute stage, and thickening and hyperpigmentation (lichenification) in the chronic stage. The incidence of skin diseases is increasing day by day. Other medical systems provide temporary relief but not a complete cure. Ayurveda can contribute remarkably in the management of skin problems. Atopic dermatitis comes under Twak vikaras which can be correlated with Charmadala described in Kashyapa samhitha. This is the case report of a nine-year-old girl with dry, itchy and scaly skin associated with blackish excoriated lesions and oozing. She visited the outpatient department of Government Ayurveda Hospital. Ayurveda medications were administered along with dietary advice for a period of three weeks, followed by inpatient treatment with internal medications along with Snehapana (intake of ghee) followed by Vamana (emesis) and external procedures like Dhara (pouring of medicated liquids) with Kushtahara (alleviates itching) and Kandughna (anti-pruritic) Dravyas along with dietary advice for a period of one month. Encouraging results were observed in the form of a reduction in itching, dryness, and excoriation. The efficacy of the treatment was assessed using SCORAD (scoring atopic dermatitis scale), where the pre-value is 54.7 and the post-value is 17. On POEM (patient-oriented eczema measure) scale evaluation the condition changed from severe eczema to clear or almost clear. Dietary restrictions and internal medication must be continued to prevent the recurrence of the condition.

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Section: Discussionmentioning

confidence: 99%

A Case Study on the Ayurvedic Management of Childhood Atopic Dermatitis

Lekshmi M K,

Thulasi A,

Nimmi K

2023

Int J Ayu Pharm Res

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“…Topical Therapy, Evolving Scenario (66)(67)(68)(69)(70)(71)(72)(73)(74)(75)(76) Although, several treatment options are in vogue, its treatment continues to loom large, because its etio-pathogenesis is largely seem to be enigmatic (66,67) nevertheless, the endeavors to unfold it are relentlessly continuing. The advent of stratum corneum (66,68), the impeccable skin barrier has taken the central stage.…”

Section: Azathioprine and Betamethasone Versusmentioning

confidence: 99%

Atopic Dermatitis: Drug Delivery (Management) and Approaches (Strategies) in Perspective

Sehgal¹

2020

ANAMS

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Age-related cutaneous manifestations are deﬁnitive pointer to the diagnosis of atopic dermatitis, the conﬁrmation of which is solicited by 3 major and 3 minor criteria. Its unpredictable course is punctuated by exacerbations and remissions. Several treatment options, namely: 1st, 2nd and 3rd line are in vogue ever since. The 1st line envisages general measures, 2nd encompasses topical applications, while the 3rd take into account drug therapy comprising, systemic Corticosteroids, Cyclosporin, Azathioprine, Thymopentin, Interferon–therapy, Topical Calcineurin inhibitors: Tacrolimus and Pimecrolimus. The mode of action, their dosages and adverse drug reaction (ADR), in particular, have been focused in this paper with special attention to refresh their drug delivery (management) approaches (strategies) in perspective. An endeavor to focus attention to emerging etio-pathogenesis, and its application in the contemporary context has also been made.

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“…Accordingly, the adult-onset AD was divided into intrinsic/nonallergic (non-I.e.-mediated) [3] type of atopic dermatitis (constitutional dermatitis) and extrinsic/allergic (Figure 2) (I.e.associated) [4,5] type, the outline of which are defined in the adjoining table 1. Its etio-pathogenesis is largely elusive [6], and a subject matter of continuing dialogue Currently, the turbulence in the functions of stratum corneum [7][8][9] the skin barrier (Figure 3), are being incriminated through genetically determined risk factors along-with the immune system dysfunction [10]. The concomitance of atopic dermatitis in immuno-compromised/susceptible genetic and metabolic disorders might re-enforce the preceding observations.…”

Section: Introductionmentioning

confidence: 99%

Age Related Clinical Spectrum of Atopic Dermatitis: A Position Paper

Sehgal¹

2018

Dermatitis

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Atopic dermatitis is well-known age-related/oriented caption recognized through well-defined clinical features usually having an onset in infancy invariably marching towards childhood, adolescent adult and elderly (senile) phases. This particular aspect seems unique, and was succinctly explored through literature, the highlights of which form the position paper for vivid comprehension of evolving clinical spectrum, which might add up to elevation of dreaded symtomatology, a part component of the entity. The criteria for intrinsic and extrinsic variant of AD, in particular, are emphasized.

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Atopic dermatitis; Etio-pathogenesis, An overview

Cited by 10 publications

References 52 publications

A Case Study on the Ayurvedic Management of Childhood Atopic Dermatitis

A Case Study on the Ayurvedic Management of Childhood Atopic Dermatitis

Atopic Dermatitis: Drug Delivery (Management) and Approaches (Strategies) in Perspective

Age Related Clinical Spectrum of Atopic Dermatitis: A Position Paper

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