Atopy and cause‐specific mortality

Skaaby, Tea; Husemoen, Lise Lotte Nystrup; Thuesen, Betina Heinsbæk; Hammer-Helmich, Lene; Linneberg, Allan

doi:10.1111/cea.12408

Cited by 13 publications

(14 citation statements)

References 34 publications

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“…Atopy was defined by determination of serum specific IgE or skin prick test positivity to inhalant allergens as described in previous studies [ 32 – 35 ]. In the 1936-cohort and the Monica1 study, serum specific IgE positivity was tested by the ADVIA Centaur Allergy Screen assay (Bayer HealthCare Diagnostics division, Tarrytown, N.Y., USA) [ 36 ].…”

Section: Methodsmentioning

confidence: 99%

Lifestyle-Related Factors and Atopy in Seven Danish Population-Based Studies from Different Time Periods

Skaaby¹,

Husemoen²,

Thuesen³

et al. 2015

PLoS ONE

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BackgroundThe prevalence of allergic respiratory disease tends to increase in populations that adopt the so-called Westernized lifestyle. We investigated the association between atopy and several possible lifestyle-related factors in seven Danish population-based studies.MethodsA total of 20048 persons participated in the seven studies. We used logistic regression to analyse the associations between possible determinants and atopy defined as serum specific IgE or skin prick test positivity against inhalant allergens. Associations were expressed as odds ratios (ORs) with 95% confidence intervals (95% CIs). In addition, individual participant data meta-analyses were performed.ResultsAtopy was significantly associated with younger age (OR per 1 year increase in age: 0.97; 95% CI: 0.97, 0.98); male sex (OR for males versus females: 1.34; 95% CI: 1.24, 1.45), heavy drinking (OR for heavy drinkers versus light drinkers: 1.15; 95% CI: 1.04, 1.27), never smoking (OR for current versus never smokers: 0.73; 95% CI: 0.67, 0.80), and higher educational level (OR for educated versus uneducated: 1.27; 95% CI: 1.15, 1.41). Atopy was not associated with blood pressure, serum total cholesterol, physical activity or body mass except in women only, where we found a positive association (OR for obese vs. normal weight: 1.18; 95% CI: 1.00, 1.39) with ptrend = 0.032.ConclusionsOf interest for preventive purposes, we found that atopy was associated with some of the reversible lifestyle-related factors that characterize a Westernized lifestyle.

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Section: Methodsmentioning

confidence: 99%

Lifestyle-Related Factors and Atopy in Seven Danish Population-Based Studies from Different Time Periods

Skaaby¹,

Husemoen²,

Thuesen³

et al. 2015

PLoS ONE

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“…By contrast, Skaaby et al did not support this hypothesis based on a study of atopy and cancer prevalence in approximately 15,000 patients [ 21 ]. Skaaby et al also noted an association between atopy and a lower risk of dying for breast cancer but not for cancer in general [ 22 ]. This study highlighted the lack of a simple link between atopy and the risk of not only neoplasms but also other chronic diseases [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

“…Skaaby et al also noted an association between atopy and a lower risk of dying for breast cancer but not for cancer in general [ 22 ]. This study highlighted the lack of a simple link between atopy and the risk of not only neoplasms but also other chronic diseases [ 22 ]. These results further support the complexity of this relationship.…”

Section: Discussionmentioning

confidence: 99%

Association between cancer and allergies

Kozłowska

Bożek

Jarząb

2016

Allergy Asthma Clin Immunol

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BackgroundThe prevalence of allergies and the incidence of cancer are both increasing worldwide. It has been hypothesized that atopy may affect the risk of some cancers.MethodsIn this study, 1525 patients (754 women and 771 men with a mean age of 52.7 ± 11.9 years) with different types of cancer were examined for the presence of allergies. Allergies were confirmed based on retrospective analysis of allergy diagnostic procedures in patients previously diagnosed with cancer. All patients were also analyzed for bronchial asthma and allergic rhinitis according to relevant guidelines. A control group of patients without cancer diagnoses was used for comparison.ResultsPatients with cancer had significantly fewer IgE-mediated allergic diseases than the control population. For the oncological group compared to the non-cancer patients, the odds ratios (ORs) for allergic rhinitis, atopic dermatitis, and bronchial asthma were 0.67 (95 % CI 0.52–0.81), 0.89 (95 % CI 0.78–0.99), and 1.03 (95 % CI 0.91–1.13), respectively. The mean serum concentrations of total IgE were significantly lower in the study population of patients with cancer than in the patients in the control group (45.98 ± 14.9 vs. 83.2 ± 40.1 IU/l; p < 0.05). There were no significant correlations between the type of cancer diagnosed and the form of allergy.ConclusionOur results indicate that the overall incidence of allergies, particularly allergic rhinitis, was lower in patients with some types of cancer. Further studies are needed to confirm our findings.

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“…As with previous studies, any scores higher than 0 (which correspond to specific IgE levels of ≥0.35 kU/L) were defined as IgE sensitization and the presence of atopy. 17 For consistency, the term IgE sensitization was used to describe specific IgE levels ≥0.35 kU/L throughout this study. When multiple allergens were tested at baseline, results for all allergen-specific IgE measurements were collected and positive IgE sensitization was defined as having at least one positive result among all the tested allergens.…”

Section: Methodsmentioning

confidence: 99%

Investigating the association between allergen-specific immunoglobulin E, cancer risk and survival

et al. 2016

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Prior findings linking allergy and cancer have been inconsistent, which may be driven by diverse assessment methods. We used serum specific immunoglobulin E (IgE) against common inhalant allergens that was assessed prior to cancer diagnosis in studying this association. We selected 8,727 Swedish men and women who had measurements of serum allergen-specific IgE and total IgE between 1992 and 1996. Multivariable Cox regression using age as a timescale was performed to assess the associations of IgE sensitization, defined by any levels of serum specific IgE ≥35 kU/L, with risk of overall and specific cancers. A test for trend was performed by assigning scores derived from allergen-specific IgE levels at baseline as an ordinal scale. Kaplan–Meier curves and log-rank test were used to assess cancer survival by IgE sensitization status. During a mean follow-up of 16 year, 689 persons were diagnosed with cancer. We found an inverse association between IgE sensitization and cancer risk, with a hazard ratio (HR) of 0.83 and 95% confidence intervals (CI) of 0.70–0.99. A similar trend was seen with specific IgE scores overall (Ptrend = 0.007) and in women (Ptrend = 0.01). Although IgE sensitization was not associated with risk of common site-specific cancers, serum specific IgE scores were inversely associated with melanoma risk in men and women combined, and with risk of female breast and gynecological cancers combined. No association with survival was observed. The association between circulating IgE levels and incident cancer may point toward a role of T-helper 2 (TH2)-biased response in development of some cancers.

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Atopy and cause‐specific mortality

Cited by 13 publications

References 34 publications

Lifestyle-Related Factors and Atopy in Seven Danish Population-Based Studies from Different Time Periods

Lifestyle-Related Factors and Atopy in Seven Danish Population-Based Studies from Different Time Periods

Association between cancer and allergies

Investigating the association between allergen-specific immunoglobulin E, cancer risk and survival

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