Atrazine and its degradates have little effect on the corticosteroid stress response in the zebrafish

Effects of atrazine on fish, amphibians, and reptiles: update of the analysis based on quantitative weight of evidence

“…Additional research was conducted to evaluate the effects of atrazine on the stress response in fish (Figure 23). This involved exposing adult zebrafish for up to 10 d to atrazine and its degradates DIA, DEA, and DACT and then measuring basal and forced swimming stress induced changes in whole body cortisol content (Van Der Kraak et al 2015). Consistent with previous studies (Fuzzen et al 2010(Fuzzen et al , 2011, these studies showed that zebrafish not exposed to atrazine (controls) exhibited an increase in whole body cortisol content following a 20 min swimming challenge.…”

“…In the course of the analysis, two papers overlooked during the development of the original WoE assessment were identified and analyzed. In the end, the papers included in the QWoE update are: (Chang et al 2005;Hecker et al 2005;Svartz et al 2012;Ghodageri and Katti 2013;Olker 2014;Shenoy 2014;Baxter et al 2015;Chen et al 2015;Sai et al 2015Sai et al , 2018Syngenta 2015Syngenta , 2017aSyngenta , 2017bVan Der Kraak et al 2015;Wirbisky and Freeman 2015;dos Santos Mendonc¸a et al 2016;Ehrsam et al 2016;Gustafson et al 2016;Khan et al 2016aKhan et al , 2016bKhan et al , 2016cLiu et al 2016;Richter et al 2016;Russart and Rhen 2016;Tulaby Dezfuly and Mohammadian 2016;Wirbisky et al 2016aWirbisky et al , 2016bWirbisky et al , 2016cD'Angelo and Freeman 2017;Du Gas et al 2017;Hoskins et al 2017;Jones et al 2017;Khalil et al 2017;Kirsten et al 2017;McMahon et al 2017;Persch et al 2017;Scott et al 2017;Shukla et al 2017;Snyder et al 2017;Wang et al 2017;…”