Atrial Function in Patients with Breast Cancer After Treatment with Anthracyclines

Yaylali, Yalın Tolga; Saricopur, Ahmet; Yurtdaş, Mustafa; Şenol, Hande; Gokoz-Dogu, Gamze

doi:10.5935/abc.20160146

Cited by 18 publications

(32 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This divergence in risk may be mediated by a higher risk of AF. Several studies have reported an association between AF and cancer (13), but there are fewer data specific to EBC (52,53). A study of patients admitted to a surgical ward reported 2% prevalence of AF in presurgery electrocardiograms for EBC patients vs 0.6% in control subjects admitted for noncancer surgery (52).…”

Section: Discussionmentioning

confidence: 99%

The Risk of Heart Failure and Other Cardiovascular Hospitalizations After Early Stage Breast Cancer: A Matched Cohort Study

Abdel‐Qadir¹,

Thavendiranathan²,

Austin³

et al. 2019

JNCI: Journal of the National Cancer Institute

View full text Add to dashboard Cite

Background Data are limited regarding the risk of heart failure (HF) requiring hospital-based care after early stage breast cancer (EBC) and its relationship to other types of cardiovascular disease (CVD). Methods We conducted a population-based, retrospective cohort study of EBC patients (diagnosed April 1, 2005–March 31, 2015) matched 1:3 on birth-year to cancer-free control subjects. We identified hospitalizations and emergency department visits for CVD through March 31, 2017. We used cumulative incidence function curves to estimate CVD incidence and cause-specific regression models to compare CVD rates between cohorts. All statistical tests were two-sided. Results We identified 78 318 EBC patients and 234 954 control subjects. The 10-year incidence of CVD hospitalization was 10.8% (95% confidence interval [CI] = 10.5% to 11.1%) after EBC and 9.1% (95% CI = 8.9% to 9.2%) in control subjects. Ischemic heart disease was the most common reason for CVD hospitalization after EBC. After regression adjustment, the relative rates compared with control subjects remained statistically significantly elevated for HF (hazard ratio [HR] = 1.21, 95% CI = 1.14 to 1.29, P < .001), arrhythmias (HR = 1.31, 95% CI = 1.23 to 1.39, P < .001), and cerebrovascular disease (HR 1.10, 95% CI = 1.04 to 1.17, P = .002) hospitalizations. It was rare for HF hospital presentations (2.9% of cases) to occur in EBC patients without recognized risk factors (age >60 years, hypertension, diabetes, prior CVD). Anthracycline and/or trastuzumab were used in 28 950 EBC patients; they were younger than the overall cohort with lower absolute rates of CVD, hypertension, and diabetes. However, they had higher relative rates of CVD in comparison with age-matched control subjects. Conclusions Atherosclerotic diagnoses, rather than HF, were the most common reasons for CVD hospitalization after EBC. HF hospital presentations were often preceded by risk factors other than chemotherapy, suggesting potential opportunities for prevention.

show abstract

Section: Discussionmentioning

confidence: 99%

The Risk of Heart Failure and Other Cardiovascular Hospitalizations After Early Stage Breast Cancer: A Matched Cohort Study

Abdel‐Qadir¹,

Thavendiranathan²,

Austin³

et al. 2019

JNCI: Journal of the National Cancer Institute

View full text Add to dashboard Cite

show abstract

“…Our study showed that minimal and pre-A LAVIs were significantly higher in the cancer patients with borderline statistical significance for maximal LAVI. Yaylali et al showed that maximal and pre-contraction LAVs were significantly higher in the patients after anthracycline therapy in comparison with the healthy controls [7]. Shi et al did not find any difference in 3DE LAVIs measured immediately after completion of anthracycline therapy in non-Hodgkin lymphoma patients and the controls [6].…”

Section: Discussionmentioning

confidence: 99%

“…Shi and Yaylali reported significantly reduced passive LAEF and increased active LAEF, which demonstrated impaired conduit LA function and elevated booster pump LA function in breast cancer and non-Hodgkin lymphoma patients treated with anthracyclines [6,7]. Both groups of authors used only volumetric evaluation of LA phasic function.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Phasic Left Atrial Function in Cancer Patients Before Initiation of Anti-Cancer Therapy

Tadić

Genger

Cuspidi

et al. 2019

JCM

View full text Add to dashboard Cite

: We aimed to explore left atrial (LA) remodeling in the patients with solid cancer before initiation of chemo- or radiotherapy. This retrospective investigation included 92 chemo- and radiotherapy-naive cancer patients and 40 age- and gender-matched controls with a similar cardiovascular risk profile as the cancer group. All participants underwent comprehensive echocardiographic examination before the start of chemo- or radiotherapy. LA phasic function was evaluated in volumetric and strain method. Indexed minimal and pre-A LA volumes were significantly higher in the cancer patients. Total and passive LA emptying fraction (EF) were significantly lower, whereas active LAEF was significantly higher in the cancer patients. LA total longitudinal strain was significantly lower in the cancer patients. Strain rate analysis of LA phasic function showed that LA function during systole and early diastole was reduced in the cancer group, while it was increased during late diastole. These findings indicated that LA reservoir and conduit functions, assessed with LA volumetric and strain analysis, were deteriorated in the cancer group. On the other hand, LA booster pump function was elevated in the cancer group in comparison with the controls. In the whole population, cancer was associated with reduced LA total longitudinal strain independently of age, gender, BMI, LV hypertrophy, E/e’ ratio, diabetes, and hypertension. LA phasic function was impaired in the chemo- and radiotherapy-naive cancer patients in comparison with the control group. Cancer, LV hypertrophy, and hypertension were associated with reduced LA longitudinal strain independently of other important clinical parameters.

show abstract

“…The growing interest in cardio-oncology (the field of cardiovascular disease in patients with cancer) 1,2,3 has been accompanied by concerns about an increased risk of developing atrial fibrillation (AF) following cancer diagnosis, 4,5,6,7,8,9,10,11,12,13,14,15 as well as a higher risk of cancer following the recognition of AF. 15,16,17,18,19,20 In fact, AF has been proposed as a marker of an occult malignant neoplasm.…”

Section: Introductionmentioning

confidence: 99%

Association of Early-Stage Breast Cancer and Subsequent Chemotherapy With Risk of Atrial Fibrillation

et al. 2019

View full text Add to dashboard Cite

show abstract

Atrial Function in Patients with Breast Cancer After Treatment with Anthracyclines

Cited by 18 publications

References 20 publications

The Risk of Heart Failure and Other Cardiovascular Hospitalizations After Early Stage Breast Cancer: A Matched Cohort Study

The Risk of Heart Failure and Other Cardiovascular Hospitalizations After Early Stage Breast Cancer: A Matched Cohort Study

Phasic Left Atrial Function in Cancer Patients Before Initiation of Anti-Cancer Therapy

Association of Early-Stage Breast Cancer and Subsequent Chemotherapy With Risk of Atrial Fibrillation

Contact Info

Product

Resources

About