Atrial natriuretic peptide elevates cGMP contents in glomeruli and in distal tubules of rat kidney

Takeda, Shigeyuki; Kusano, Eiji; Murayama, Naoki; Asano, Yoshihide; Hosoda, Saichi; Sokabe, Hirofumi; Kawashima, Hiroyuki

doi:10.1016/0006-291x(86)90424-9

Cited by 22 publications

(8 citation statements)

References 14 publications

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“…Despite numerous investigations of its renal mechanisms of action, the exact processes involved are still not fully understood. High concentrations of particulate guanylate cyclase and cGMP levels elevated by ANP have been noted in glomeruli (6)(7)(8)(9), which possess an abundance of specific ANP receptors (6,(10)(11)(12)(13)(14).…”

Section: Introductionmentioning

confidence: 99%

Increased cyclic guanosine monophosphate production and overexpression of atrial natriuretic peptide A-receptor mRNA in spontaneously hypertensive rats.

Tremblay

Huot²,

Willenbrock³

et al. 1993

J. Clin. Invest.

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Atrial natriuretic peptide (ANP) specifically stimulates particulate guanylate cyclase, and cyclic guanosine monophosphate (cGMP) has been recognized as its second messenger. Spontaneously hypertensive rats (SHR) have elevated plasma ANP levels, but manifest an exaggerated natriuretic and diuretic response to exogenous ANP when compared to normotensive strains. In isolated glomeruli, the maximal cGMP response to ANP corresponds to a 12-to 14-fold increase over basal levels in normotensive strains (Wistar 13±2; Wistar-Kyoto 12+2;Sprague-Dawley 14±2) while a maximal 33±3-fold elevation occurs in SHR (P < 0.001). This hyperresponsiveness of cGMP is reproducible in intact glomeruli from SHR from various commercial sources. Furthermore, this abnormality develops early in life, even before hypertension is clearly established, and persists despite pharmacological modulation of blood pressure, indicating that it is a primary event in hypertension.In vitro studies have revealed a higher particulate guanylate cyclase activity in membranes from glomeruli and other tissues from SHR. This increase is not accounted for by different patterns of ANP binding to its receptor subtypes between normotensive and hypertensive strains, as assessed by competitive displacement with C-ANP'02-121, an analog which selectively binds to one ANP receptor subtype. The hyperactivity of particulate guanylate cyclase in SHR and its behavior under basal, ligand (ANP), and detergent-enhanced conditions could be attributed either to increased expression or augmented sensitivity of the enzyme. Radiation-inactivation analysis does not evoke a disturbance in the size of regulatory elements normally repressing enzymatic activity, while the expression of particulate guanylate cyclase gene using mutated standard of A-and B-receptors partial cDNAs, quantified by polymerase chain reaction (PCR) transcript titration assay, manifests a selective increase of one guanylate cyclase subtype. Our data suggest that in hypertension, genetic overexpression of the ANP A-receptor subtype is related to the exaggerated biological response to ANP in this disease. (J. Clin. Invest. 1993. 92:2499-2508

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Section: Introductionmentioning

confidence: 99%

Increased cyclic guanosine monophosphate production and overexpression of atrial natriuretic peptide A-receptor mRNA in spontaneously hypertensive rats.

Tremblay

Huot²,

Willenbrock³

et al. 1993

J. Clin. Invest.

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“…in renal glomeruli, mesangium, the vessels of microcirculation, as well as in renal tubules (Chai et al 1986;Healy and Fanestil 1986;Lynch et al 1986;Rutherford et al 1994;Takeda et al 1986;Wilcox et al 1991).…”

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confidence: 99%

Atrial Natriuretic Peptide and Renal Haemodynamics in Newborn Calves

Dratwa

2006

Acta Vet. Brno

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Dratwa A.: Atrial Natriuretic Peptide and Renal Haemodynamics in Newborn Calves. Acta Vet. Brno 2006, 75: 477-483.The study was aimed to provide information on the dynamics of changes in the concentration of ANP in blood plasma of calves during the first seven days of their life and to find any association between blood plasma ANP concentration and effective renal blood (ERBF) and plasma flow (ERPF) and glomerular filtration rate (GFR). The experiment was carried out on 10 clinically healthy Black and White calves during the first seven days of postnatal life. The concentration of atrial natriuretic peptide (ANP) in blood plasma was determined with radioimmunoassay. The kidney function was assessed by clearance methods, using para-aminohippuric acid and inulin. The blood plasma ANP concentration increased with age. On the first day the mean concentration of ANP was 5.72 ± 1.34 pmol/l, on the 7 th day it was 14.34 ± 2.09 pmol/l. The ERBF and ERPF during the first week of life showed variations, mean ERBF ranging within 280.22 ± 10.30 ml/min/m 2 (1 st day) and 338.25 ± 13.72 ml/min/m 2 (7 th day) and ERPF ranging between 179.77 ± 8.27 ml/min/m 2 (1 st day) and 245.22 ± 9.86 ml/min/m 2 (7 th day). The mean GFR on the first day was 35.68 ± 2.10 ml/min/m 2 and significantly (p ≤ 0.01) increased on the second day 49.97 ± 1.76 ml/min/m 2 , subsequently GFR remained on a stabile level average 51.06 ml/min/m 2 . The studies showed no correlations between plasma ANP concentration and ERPF (ERBF) and GFR. These data indicate that in calves during the first seven days of postnatal life endogenous ANP did not change the effective renal blood (plasma) flow and glomerular filtration rate.

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“…Consistent with this, studies have provided evidence for stimulation of cGMP production in various renal tubule segments in response to ANP (Nonoguchi et al, 1987;Takeda et al, 1986) and for the expression of the cGMP-coupled ANP receptor in these segments (Terada et al, 1991). However, the effect of ANP (through an increase in cGMP) on sodium and fluid transport in the collecting duct is still controversial.…”

Section: Atrial Natriuretic Peptide (Anp)mentioning

confidence: 75%