Atropa acuminata Royle Ex Lindl. blunts production of pro-inflammatory mediators eicosanoids., leukotrienes, cytokines in vitro and in vivo models of acute inflammatory responses

Nisar, Albeena; Malik, Akhtar H.; Zargar, Mohammad Afzal

doi:10.1016/j.jep.2013.03.038

Cited by 11 publications

(5 citation statements)

References 57 publications

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“…At early ages, it contains low amounts of alkaloids, but the contents increase at the flowering stage 16 . According to a report, the ethanolic extract from the leaves of the plant contains approximately 188 micro grams of phenolic compounds per ml extract, which is a huge amount compared to other plants in the family 17 .…”

Section: Introductionmentioning

confidence: 99%

In vitro biological screening of a critically endangered medicinal plant, Atropa acuminata Royle Ex Lindl of north western Himalaya

Rahman

Khan

Fahad

et al. 2018

Sci Rep

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Atropa acuminata Royle Ex Lindl (Atropa acuminata) under tremendous threat of extinction in its natural habitat. However, the antimicrobial, antileishmanial and anticancer effects of the plant’s extracts have not been reported yet. In the current study, an attempt has been made to evaluate the pharmacological potential of this plant’s extracts against microbes, Leishmania and cancer. The roots, stems and leaves of Atropa acuminata were ground; then, seven different solvents were used alone and in different ratios to prepare crude extracts, which were screened for pharmacological effects. The aqueous, methanolic and ethanolic extracts of all parts carried a broad spectrum of anti-bacterial activities, while no significant activity was observed with combined solvents. Three types of cytotoxicity assays were performed, i.e., haemolytic, brine shrimp and protein kinase assays. The aqueous extract of all the parts showed significant haemolytic activity while n-hexane extracts of roots showed significant activity against brine shrimp. The acetone extracts strongly inhibited protein kinase while the methanolic extracts exhibited significant cytotoxic activity of roots and stem. The anti-leishmanial assays revealed that the methanolic extract of leaves and roots showed significant activity. These findings suggest that this plant could be a potential source of natural product based drugs.

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Section: Introductionmentioning

confidence: 99%

In vitro biological screening of a critically endangered medicinal plant, Atropa acuminata Royle Ex Lindl of north western Himalaya

Rahman

Khan

Fahad

et al. 2018

Sci Rep

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“…According to Jayakanthi et al [31] ethanolic extracts of A. acuminata was active against the damaging effects of free radical produced by acetaminophen induced hepatotoxicity. Nisar et al [37] reported that ethanolic extract of A. acuminata significantly increase the level of antioxidant enzymes such as superoxide dismutases, glutathione peroxidase and glutathione reductase. In current research work fruit extracts of M. nigra in methanol, ethanol, and chloroform showed higher antioxidant activity.…”

Section: Discussionmentioning

confidence: 99%

Comparative Evaluation of Biological Activities, Bioautography and Spot Screening of Boiled and Macerated Extracts of Medicinal Plants against Zoonotic Pathogens

Ilyas

Andleeb

Babar

et al. 2016

BMRJ

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“…In any case, mitigating drug generally dangers of poisonousness for long haul use, which indeed restricts their utilization. Momentum research in the administration of rheumatoid joint in lammation is going to another age of substances able to do speci ically hindering TNF alpha or potentially and having no signi icant symptoms [11]. Ongoing enthusiasm for elective medicines for joint in lammation favours the utilization of conventional medication, albeit logical proof of adequacy for most cases is inadequate.…”

Section: Introductionmentioning

confidence: 99%

“…Ongoing enthusiasm for elective medicines for joint in lammation favours the utilization of conventional medication, albeit logical proof of adequacy for most cases is inadequate. By the by, a few spices, utilized in a consideration sequencer and a powerful precautionary medication, can act independently and additionally in collaboration to diminish interminable joint aggravation ( well as rheumatoid joint in lammation) [4,[9][10][11]. To arrive at the absolute medical care inclusion of the total populace, customary medication is considered by WHO to be the best methods since about 25% of present-day physician recommended drugs are pretty much acquired from plants [12,13].…”

Section: Introductionmentioning

confidence: 99%

Study of anti-inflammatory and antiarthritic activities of aqueous and ethanolic plant extracts in animal models

K¹,

Naveen²,

A³

et al. 2020

irjpas

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The tropical plant generally utilized in conventional Cameroonian medication to assuage and extravagance numerous pathologies. It is boundless in the western district where it is utilized to treat typhoid fever, gastrointestinal issues, and provocative ailments. Rheumatoid joint pain (RA) is a ceaseless, incapacitating, and dynamic immune system sickness in which incessant irritation aide saw with noteworthy bone annihilation and ligament obliteration bringing about critical joint harm and decreased usefulness. This pathology can develop rapidly in an individual and influence a few pieces of the body that become aggravated or amazingly agonizing, especially influencing the old, yet additionally people with a degenerative bone issue or insusceptible framework brokenness. This pathology, which can likewise happen because of the invulnerable framework assaulting the synovial layer, is joined by growing, solidness, torment, and a decrease or loss of joint capacity. The motivation behind this examination is to logically exhibit the mitigating and antiarthritic properties of the fluid and ethanolic concentrates of the shrubberies of Dissotis thollonii. The calming properties were assessed in vitro by restraint tests for cyclooxygenase, 5-lipoxygenase, protein denaturation, extracellular ROS creation, and cell expansion. In contrast, antiarthritic properties were assessed in vivo in rodents utilizing the zymosan An initiated monoarthritis examination and the CFA-prompted polyarthritis model.

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Atropa acuminata Royle Ex Lindl. blunts production of pro-inflammatory mediators eicosanoids., leukotrienes, cytokines in vitro and in vivo models of acute inflammatory responses

Cited by 11 publications

References 57 publications

In vitro biological screening of a critically endangered medicinal plant, Atropa acuminata Royle Ex Lindl of north western Himalaya

In vitro biological screening of a critically endangered medicinal plant, Atropa acuminata Royle Ex Lindl of north western Himalaya

Comparative Evaluation of Biological Activities, Bioautography and Spot Screening of Boiled and Macerated Extracts of Medicinal Plants against Zoonotic Pathogens

Study of anti-inflammatory and antiarthritic activities of aqueous and ethanolic plant extracts in animal models

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