ATS/ ERS spirometry quality criteria in real life. Results of two occupational field studies

Berresheim, Hans; Beine, Alexandra; Kampen, V. van; Lehnert, Martin; Nöllenheidt, C; Brüning, Thomas; Hoffmeyer, Frank

doi:10.1016/j.resp.2023.104094

Cited by 2 publications

(1 citation statement)

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“…At baseline evaluation, patients underwent spirometry to investigate the presence of ventilatory deficit. In the case of an obstructive ventilatory deficit, defined according to the criteria of the American Thoracic Society (ATS) and the European Respiratory Society (ERS), the patient underwent the standard broncho-reversibility test [41,42]. Bronchodilator reversibility was defined as an increase in FEV1 of ≥ 12% and 200 mL [43,44].…”

Section: Pulmonary Function Testsmentioning

confidence: 99%

Eosinophilic Patterns in Patients with Seasonal Allergy Affected by Bronchial Asthma and Rhinitis/Rhinosinusitis: Efficacy of Benralizumab in Patients with the Persistent Pattern

D’Aiuto,

Mormile,

Granata

et al. 2024

JCM

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Background: Eosinophilia can be influenced by multiple factors. This study aims to set a protocol for monitoring blood absolute eosinophil count (AEC) in patients with seasonal allergy affected by bronchial asthma (BA), allergic rhinitis (AR), or chronic rhinosinusitis with or without nasal polyposis (CRSw/sNP). Methods: We planned a total of four annual blood samples to measure AEC in- and out-seasonal pollen exposure (i.e., one measurement every three months for one year). Results: We identified two distinct groups of patients (non-eosinophilic and eosinophilic). Patients in the eosinophilic group presented with four different patterns (episodic, transient, floating, and persistent). Most patients with episodic, transient, and floating patterns were affected by mild allergy and the increase in eosinophils was related to allergen exposure. In contrast, patients with the persistent pattern mostly presented with more severe allergy (i.e., severe BA and relapsing CRSwNP) and the eosinophilia was unrelated to allergen exposure. The subgroup of patients with severe BA, relapsing CRSwNP, and persistent eosinophilc pattern were treated with benralizumab, which induced a noteworthy improvement in both severe BA and CRSwNP. Conclusions: Multiple AEC measurements in patients with seasonal allergy can better reflect patient’s eosinophilic status and help define the relationship of AEC enhancement with allergen exposure.

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