Attenuated oocyte fertilization and embryo development associated with altered growth factor/signal transduction induced by endometriotic peritoneal fluid

Ding, Guo‐Lian; Chen, Xijing; Luo, Qiong; Dong, Minyue; Wang, Ning; Huang, He‐Feng

doi:10.1016/j.fertnstert.2009.11.011

Cited by 31 publications

(26 citation statements)

References 45 publications

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“…Qiao et al [30] reported that FF from patients with endometriosis undergoing IVF resulted in significantly decreased binding of spermatozoa to the zona compared with patients with tubal factor.. In a mouse model, exposure of oocytes to endometriotic peritoneal fluid was found to attenuate oocyte fertilization [31]. Interestingly, a previous study which compared the fertilization rate and embryonic development of oocytes randomly inseminated by conventional IVF or ICSI in patients with polycystic ovarian syndrome (PCOS) and normozoospermic semen during IVF cycles found a significantly higher fertilization rate in the ICSI group.…”

Section: Discussionmentioning

confidence: 99%

Conventional IVF versus ICSI in sibling oocytes from couples with endometriosis and normozoospermic semen

Komsky-Elbaz

Raziel

Friedler

et al. 2012

J Assist Reprod Genet

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Purpose This study compares the fertilization rate and embryonic development of oocytes randomly inseminated by conventional IVF or ICSI in patients with endometriosis and normozoospermic semen during IVF cycles. Methods Sibling oocytes were randomized to be inseminated either by ICSI or IVF. Rates of fertilization, cleavage, blastulation and embryonic morphology were assessed. Results A total of 786 sibling cumulus-oocyte complexes (COC) were randomized between insemination by conventional IVF (387 COC) or ICSI (399 COC). A significantly higher fertilization rate was found in the ICSI group (ICSI versus IVF, 73.3±23 % versus 54.7±31.9 % respectively; P=0.003), yielding a higher mean number of day 2 embryos (5.2±3.4 versus 3.6±2.9 respectively; P=0.002). Triploid fertilization rate (3PN/COC) was significantly higher in the IVF group compared to the ICSI group (3.9±8.7 % versus 0.9±3.1 % respectively; P=0.02). The morphology score and rate of development of day 2 and 3 embryos were not different between the two groups. Comparison of embryo transfer cycles in which either IVF or ICSI only embryos were transferred did not reveal any statistically significant differences in pregnancy or implantation rates.Conclusion ICSI appears to be a better treatment option than conventional IVF in endometriosis-associated infertility, since it offers the advantages of higher fertilization rate and mean number of embryos and lower rate of total fertilization failure and triploid fertilization.

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Section: Discussionmentioning

confidence: 99%

Conventional IVF versus ICSI in sibling oocytes from couples with endometriosis and normozoospermic semen

Komsky-Elbaz

Raziel

Friedler

et al. 2012

J Assist Reprod Genet

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“…In addition, some investigators have suggested that the dominance of proinflammatory cytokines in peritoneal and tubal fluid in women with endometriosis may have an adverse effect on oocyte quality and/or embryo development [88,89]. At a clinical level, this hypothesis is further supported by studies demonstrating a decreased pregnancy rates when IVF-ET treatment is performed using donated oocytes obtained from women with endometriosis as compared to when oocyte donors did not have endometriosis [90].…”

Section: Endometriosismentioning

confidence: 99%

Tubal transport of gametes and embryos: a review of physiology and pathophysiology

Ezzati

Djahanbakhch

Arian³

et al. 2014

J Assist Reprod Genet

106

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With the advent of assisted reproductive technology in the past three decades, the clinical importance of fallopian tubes has been relatively overlooked. However, successful spontaneous conception requires normal function of the tube to provide not only a conduit for the gametes to convene and embryo to reach the uterine cavity, but also a physiologically optimized environment for fertilization and early embryonic development. In this review, after a brief description of normal human tubal anatomy and histology, we will discuss tubal transport and its principal effectors, including ciliary motion, muscular contractility and tubal fluid. Furthermore, we will discuss the ciliary ultrastructure and regulation of ciliary beat frequency by ovarian steroids, follicular fluid, angiotensin system, autonomic nervous system and other factors such as adrenomedullin and prostaglandins. In the last section, we describe the adverse impact of various pathological conditions, such as endometriosis, infection and smoking on tubal function and ciliary motility.

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“…PF of women with endometriosis contains elevated amounts of macrophages [3], cytokines [4][5][6] growth factors [7] and angiogenic factors [8]. The reproductive organs are 1024 bathed in PF and pelvic alteration on the production of such factors may be accused for problem on ovum maturation, fertilization, embryo development and implantation [9].…”

Section: Introductionmentioning

confidence: 99%

Downregulative Effects of Nitric Oxide on Oocyte Fertilization and Embryo Development: Possible Roles of Nitric Oxide in the Pathogenesis of Endometriosis-associated Infertility

Luo

Chen

Ding

et al. 2010

Cell Physiol Biochem

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Aims: To investigate the effects of elevated nitric oxide (NO) levels in peritoneal fluids (PF) on oocyte fertilization and pre-implantation embryo development, and the relation of those effects to endometriosis-associated infertility. Methods: PF from women undergoing laparoscopy for infertility of minor endometriosis, tubal blockage and operation for tubal ligation was aspired at the pouch of the cul-de-sac during surgery. Oocytes and embryos of adult ICR mice were cultured in vitro with or without endometriotic PF. The fertilization rate of oocyte and the cleavage rate of 2-cell embryos were examined. Also, the clinical indexes of IVF-ET of women with minor endometriosis and tubal infertility were analyzed. Results: Oocyte fertilization rate of endometriotic women with IVF-ET treatment was significantly lower than that of tubal block women. The dose-related adverse effects of endometriotic PF and SNP (NO donor) in culture medium on oocyte fertilization and embryos development were confirmed. Conclusion: Increased NO levels in PF play an important role in mediating the effects of endometriotic PF on oocyte fertilization and embryo development. IVF might serve as an alternative treatment for endometriosis-associated infertility.

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Attenuated oocyte fertilization and embryo development associated with altered growth factor/signal transduction induced by endometriotic peritoneal fluid

Cited by 31 publications

References 45 publications

Conventional IVF versus ICSI in sibling oocytes from couples with endometriosis and normozoospermic semen

Conventional IVF versus ICSI in sibling oocytes from couples with endometriosis and normozoospermic semen

Tubal transport of gametes and embryos: a review of physiology and pathophysiology

Downregulative Effects of Nitric Oxide on Oocyte Fertilization and Embryo Development: Possible Roles of Nitric Oxide in the Pathogenesis of Endometriosis-associated Infertility

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