Attenuating Effect of Uvaria Narum (Dunal) Wall. Leaves on Thioacetamide Induced Hepatic Injury

Abstract

The objective of the present study was to evaluate the hepatoprotective potential of Uvaria narum leaf extract at two different doses (200 and 400 mg / kg b.w.) against thioacetamide induced Hepatic injury. Thioacetamide at dose of 100 mg / kg induced liver toxicity, which was assessed by quantifying the serum hepatic biomarkers like SGPT, SGOT, ALP, total and direct bilirubin, serum biochemical parameters like albumin, total protein, cholesterol, triglycerides, glucose and urea and oxidative parameters like glutathione, catalase, superoxide dismutase and lipid peroxidation in hepatic tissue. Further study was supported by histopathology studies. The results revealed that Silymarin (100 mg / kg b.w.) and Uvaria narum leaf extract at both doses prevented the elevation of serum hepatic biomarkers and also altered serum biochemical parameters dose dependently. Whereas decrease in lipid peroxidation and elevation in catalase, glutathione and superoxide dismutase was observed in Silymarin and extract treated animals. Histopathological changes in hepatic tissue also supported the dose dependent protective effect of Uvaria narum leaf extract. The results were comparable to reference standard Silymarin.