Attenuating Effect of Vitamin E against Silver Nano Particles Toxicity in Submandibular Salivary Glands

Abstract

Silver nanoparticles (AgNPs) are extensively used in many industries due to their superior antimicrobial properties. However, it is evident from many studies that AgNPs has cytotoxic potential through its effect on excessive formation of reactive oxygen species (ROS). The aim of this study was to examine the toxic effect of AgNPs on the submandibular salivary glands and the attenuating effect of vitamin E, as a natural antioxidant, against this toxicity. Thirty Albino rats were divided into 3 groups (n = 10): control group, AgNPs group receiving 2 mg/kg daily for 28 days, and AgNPs and vitamin E group receiving AgNPs the same as the previous group in addition to vitamin E at a dose of 100 mg/kg. Microscopic, ultrastructural, and cytokeratin immune-reactivity examination of the glands were performed. The AgNPs group showed noticeable degeneration in all structures of the gland as evident in the histological and ultrastructural examination. The AgNPs and vitamin E group revealed an improvement of the glandular elements. A significant increase in cytokeratin immune expression was found after comparison of both groups (p = 0.01). This current study shows that vitamin E has powerful antioxidant properties, which can combat the cytotoxic effect caused by AgNPs. Further studies are deemed necessary to confirm this finding using other immunohistochemical markers, such as myosin and E-cadherin.

Phyto-Synthesis, Characterization, and In Vitro Antibacterial Activity of Silver Nanoparticles Using Various Plant Extracts

“…Due to their exceptional antibacterial qualities, silver nanoparticles (Ag-NPs) are widely used in a variety of industries. However, numerous investigations have shown that Ag-NPs have the potential to be cytotoxic due to their impact on the excessive generation of reactive oxygen species (ROS) in various cells and pathological conditions like cancer [ 62 ]. Ag-NPs have strong antimicrobial properties against many fungi, viruses, and bacteria due to their activity as photocatalysts and their ability to produce reactive oxygen species [ 1 ].…”

Toxicological profile of nanopreparations: methods of assessment and risk analysis for dental treatment

“…Цитотоксичность наночастиц серебра при регулярном внутрисосудистом введении отмечалась и на клетках поднижнечелюстных слюнных желез. У лабораторных крыс, которым в течение 28 дней делали инъекции раствора наночастиц серебра, регистрировались дегенеративные изменения в ацинусах и протоках желез, что проявлялось в первую очередь в виде вакуолизации цитоплазмы [30].…”

Balancing Risks versus Benefits: Vitamin C Therapy versus Copper Oxide Nanoparticles Toxicity in Albino Rats' Submandibular Salivary Gland

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