Attenuation of hyperactivity in the spontaneously hypertensive rat by amphetamine

Myers, Michael; Musty, Richard E.; Hendley, Edith D.

doi:10.1016/s0163-1047(82)91397-8

Cited by 92 publications

(50 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There are also genetic models, including the SHR, which was bred from progenitor WKY rats [35,37,39,41,51,64]. The SHR strain is a genetic mutant of WKY, which has led many researchers to use the SHR strain as the animal model for ADHD and the WKY rats as their control strain.…”

Section: Discussionmentioning

confidence: 99%

Acute and chronic methylphenidate dose–response assessment on three adolescent male rat strains

Peng¹,

Swann²,

Dafny³

2006

Brain Research Bulletin

View full text Add to dashboard Cite

Methylphenidate (MPD), commonly known as Ritalin, is the most frequently prescribed drug to treat children and adults with attention deficit hyperactivity disorder (ADHD). Adolescence is a period of development involving numerous neuroplasticities throughout the central nervous system (CNS). Exposure to a psychostimulant such as MPD during this crucial period of neurodevelopment may cause transient or permanent changes in the CNS. Genetic variability may also influence these differences. Thus, the objective of the present study was to determine whether acute and chronic administration of MPD (0.6, 2.5, or 10.0 mg/kg, i.p.) elicit effects among adolescent WKY, SHR, and SD rats and to compare whether there were strain differences. An automated, computerized, open-field activity monitoring system was used to study the dose response characteristics of acute and repeated MPD administration throughout the 11-day experimental protocol. Results showed that all three adolescent rat groups exhibited dose-response characteristics following acute and chronic MPD administration, as well as strain differences. These strain differences depended on the MPD dose and locomotor index. Chronic treatment of MPD in these animals did not elicit behavioral sensitization, a phenomenon described in adult rats that is characterized by the progressive augmentation of the locomotor response to repeated administration of the drug. These results suggest that the animal's age at time of drug treatment and strain/genetic variability play a crucial role in the acute and chronic effect of MPD and in the development of behavioral sensitization.

show abstract

Section: Discussionmentioning

confidence: 99%

Acute and chronic methylphenidate dose–response assessment on three adolescent male rat strains

Peng¹,

Swann²,

Dafny³

2006

Brain Research Bulletin

View full text Add to dashboard Cite

show abstract

“…SHR shows enhanced norepinephrine release by glutamate compared with WKY but normal release by electrical stimulus. 24,25) It was reported that the hyperactivity was ameliorated by treatment of methylphenidate and D-amphetamine 26,27) and this phenomenon is associated with abnormalities in DAT.…”

Section: Animal Models Of Ad/hdmentioning

confidence: 98%

Animal Models of Attention-Deficit/Hyperactivity Disorder

Arime

Kubo

Sora

2011

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

Attention-deficit hyperactivity disorder (AD/HD) is a clinically heterogenous disorder including hyperactivity, impulsivity, and inattention. Both psychostimulant and non-psychostimulant drugs such as methylphenidate and atomoxetine, respectively, to modulate catecholeamine neurotransmission are used as current pharmacotherapies for AD/HD. Multiple lines of evidence suggest that genetic factors play major roles in the etiology of AD/HD. meta-Analyses and pooled data analyses have suggested associations between AD/HD and polymorphisms in genes encoding monoamine neurotransmission molecules. There has been considerable research on this disorder using genetic, pharmacological, and neuroimaging approaches, and several animal models of AD/HD such as spontaneously hypertensive rat (SHR), dopamine transporter (DAT) knockout mice, coloboma mutant mouse, and Grin1 mutant mouse have been reported. These animal models are valuable tools for investigating molecular, cellular, and behavioral mechanisms as well as the neural development and circuit mechanisms of AD/HD. Here, we review the recent literature on animal models of AD/HD and discuss their advantages and limitations.

show abstract

“…However, the inhibition of NA release by the alpha 2 -autoreceptor may be deficient (Reja et al 2002;Russell et al 2000a, b;Tsuda et al 1990) suggesting an overall increased noradrenergic transmission in SHR. Finally, the behavioural deficits can be attenuated with monoaminergic agents (Boix et al 1998;Myers et al 1982). The SHR shows therefore several aspects of face validity, construct validity and predictive validity.…”

Section: Animal Models Of Adhdmentioning

confidence: 99%

Animal models of attention deficit/hyperactivity disorder (ADHD): a critical review

Sontag

Tucha

Walitza

et al. 2010

ADHD Atten Def Hyp Disord

103

View full text Add to dashboard Cite

Attention deficit/hyperactivity disorder (ADHD) involves clinically heterogeneous problems including attention deficits, behavioural hyperactivity and impulsivity. Several animal models of ADHD have been proposed, ranging from models with neurotoxic lesions to genetically manipulated animals. An ADHD model is supposed to show phenomenological similarities with the disorder, i.e. it should mimic the three core symptoms (face validity). A model should also conform to an established or hypothesized pathophysiological basis of the disorder (construct validity).Finally, an animal model should be able to predict previously unknown aspects of the neurobiology of ADHD or to provide potential new treatments (predictive validity). The currently proposed models are heterogeneous with regard to their pathophysiological alterations and their ability to mimic behavioural symptoms and to predict response to medication. This might reflect the heterogeneous nature of ADHD. Since the knowledge about the biology of ADHD from human studies is limited, one cannot at present decide which model best represents ADHD or certain ADHD subtypes. Animal models with good face and predictive validity may be useful for investigations of the underlying biological substrates of ADHD. At present, the models in use should be described as animal models of ADHD-like symptoms rather than models of ADHD.

show abstract

Attenuation of hyperactivity in the spontaneously hypertensive rat by amphetamine

Cited by 92 publications

References 18 publications

Acute and chronic methylphenidate dose–response assessment on three adolescent male rat strains

Acute and chronic methylphenidate dose–response assessment on three adolescent male rat strains

Animal Models of Attention-Deficit/Hyperactivity Disorder

Animal models of attention deficit/hyperactivity disorder (ADHD): a critical review

Contact Info

Product

Resources

About