Attenuation of isoproterenol-induced cardiotoxicity in rats by Narirutin rich fraction from grape fruit

Shaikh, Shagufta; Bhatt, Lokesh Kumar; Barve, Kalyani

doi:10.1016/j.phymed.2018.06.037

Cited by 24 publications

(19 citation statements)

References 24 publications

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“…However, precotreatment with 7-hyd.HC lessened the oxidative stress produced by ISO, which reduced lipid peroxidation, and increased the activities of the studied antioxidant enzymes (SOD, CAT, and GPx), as well as GSH contents. Therefore, the inhibition of lipid peroxidation with activation of antioxidant activities is considered a protection from MI [2]. The beneficial role of 7-hyd.HC seemed to be due to the scavenging of reactive oxygen species generated by the metabolism of isoproterenol, which could protect the cardiac tissue from oxidative stressinduced injury.…”

Section: Discussionmentioning

confidence: 99%

“…Cardiovascular disease (CVD) is one of the global health emergencies of the 21st century, which caused 17.9 million dead people in 2015 and this may rise up to 23.6 million by the year 2030 [1]. Myocardial infarction (MI) is the commonest form of this disease which is characterized by insufficient supply of myocardial oxygen compared to demand leading to myocardial hypoxia and necrosis [2]. More insights into the mechanism of myocardial infarction through various researches have revealed the role of oxidative stress in promoting lipid peroxidation, inflammation, and apoptosis in the myocardium by excessive production of free radicals [3,4].…”

Section: Introductionmentioning

confidence: 99%

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(E)-N′-(1-(7-Hydroxy-2-Oxo-2H-Chromen-3-Yl) Ethylidene) Benzohydrazide, a Novel Synthesized Coumarin, Ameliorates Isoproterenol-Induced Myocardial Infarction in Rats through Attenuating Oxidative Stress, Inflammation, and Apoptosis

Feriani

Khdhiri

Tir

et al. 2020

Oxidative Medicine and Cellular Longevity

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The present study was directed to investigate the effect of precotreatment with (E)-N′-(1-(7-hydroxy-2-oxo-2H-chromen-3-yl) ethylidene) benzohydrazide (7-hyd.HC), a novel potent synthesized coumarin, on isoproterenol- (ISO-) induced myocardial infarction (MI) in rats. The hydrazone compound was characterized by IR, 1D, and 2D NMR analyses. Experimental induction of MI in rats was established by ISO (85 mg/kg/day, s.c) for two consecutive days (6th and 7th days). 7-hyd.HC or sintrom was given for 7 days prior and simultaneous to ISO injection. 7-hyd.HC offered a cardiopreventive effect by preventing heart injury marker leakage (LDH, ALT, AST, CK-MB, and cTn-I) from cardiomyocytes and normalizing cardiac function and ECG pattern, as well as improving lipid profile (TC, TG, LDL-C, and HDL-C), which were altered by ISO administration. Moreover, 7-hyd.HC precotreatment significantly mitigated the oxidative stress biomarkers, as evidenced by the decrease of lipid peroxidation and the increased level of the myocardial GSH level together with the SOD, GSH-Px, and catalase activities. 7-hyd.HC inhibited the cardiac apoptosis by upregulating the expression of Bcl-2 and downregulating the expression of Bax and caspase-3 genes. In addition, 7-hyd.HC reduced the elevated fibrinogen rate and better prevented the myocardial necrosis and improved the interstitial edema and neutrophil infiltration than sintrom. Overall, 7-hyd.HC ameliorated the severity of ISO-induced myocardial infarction through improving the oxidative status, attenuating apoptosis, and reducing fibrinogen production. The 7-hyd.HC actions could be mediated by its antioxidant, antiapoptotic, and anti-inflammatory capacities.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

(E)-N′-(1-(7-Hydroxy-2-Oxo-2H-Chromen-3-Yl) Ethylidene) Benzohydrazide, a Novel Synthesized Coumarin, Ameliorates Isoproterenol-Induced Myocardial Infarction in Rats through Attenuating Oxidative Stress, Inflammation, and Apoptosis

Feriani

Khdhiri

Tir

et al. 2020

Oxidative Medicine and Cellular Longevity

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“…Therefore, our results suggest that PN might play an anti-inflammatory role through which it contributes to cardioprotection. As ISO is widely used to induce acute MI in rat models, it not only stimulates the release of pro-inflammatory cytokines, but also stimulates oxidative stress [1, 2, 4, 10, 21]. In addition, the alleviation of MI, as reflected by the reduction of TNF- α and IL-6 levels and ROS generation, correlates well with the silent information regulator 1-Nrf2-HO-1 pathway [22, 23].…”

Section: Discussionmentioning

confidence: 99%

“…Research into the potential of new therapeutic agents to treat MI has been facilitated by the use of animal models. For instance, the administration of isoproterenol (ISO), a β ‐adrenergic receptor agonist, was used to mimic the characteristics of MI in rats to study the effectiveness of medicinal plants or active compounds in disease intervention [1, 2]. ISO administration also causes an elevation in the ST segment in ECG readings.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, it caused an increase in the levels of cardiac injury biomarkers, including troponin I, troponin T, creatine kinase-MB, lactate dehydrogenase, alkaline phosphatase, serum glutamic oxaloacetic transaminase, aspartate transaminase, and alanine transaminase [1–4]. ISO-treated rats exhibited myocardial cell swelling, myocardial degeneration, loss of myofibrils, and diffuse infiltration of inflammatory cells [1, 2, 4]. There was also an increase in cardiac tissues and serum levels of the pro-inflammatory cytokines interleukin-6 (IL-6) and tumor necrosis factor- α (TNF- α ) [1, 4].…”

Section: Introductionmentioning

confidence: 99%

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Phikud Navakot Modulates the Level of Pro-Inflammatory Mediators and the Protein Expression of SOD1 and 2 and the Nrf2/HO-1 Signaling Pathway in Rats with Acute Myocardial Infarction

Gerdprasert

Choomchuay

Chantong

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Phikud Navakot (PN) is nine major herbs in a famous traditional Thai recipe namely “Yahom Navakot” used to treat cardiovascular disorders. This study investigated the cardioprotective effects of PN formula on isoproterenol-induced myocardial infarction (IMI) in Sprague-Dawley rats. Forty-five rats were randomly divided into nine groups (n = 5 per group): the control, the IMI, the IMI + propranolol, the control or the IMI + PN formula (PN ethanolic extract at doses of 64, 127, or 255 mg/kg) by oroesophageal gavage for 28 days. The ST segment and serum troponin T levels were significantly increased in IMI rats. PN did not eliminate tissue necrosis, infiltration of inflammatory cells, or interstitial edema in IMI rats. All doses of PN decreased (p<0.001) serum TNF-α and IL-6 levels. PN (127 and 255 mg/kg) up-regulated (p<0.05) heme oxygenase (HO)-1 expression, whereas PN (255 mg/kg) significantly increased superoxide dismutase (SOD) 1 and 2 expression, compared with IMI rats. Nuclear factor erythroid 2-related factor 2 (Nrf2) and HO-1 expression significantly increased in IMI rats and IMI rats that received PN. PN formula possesses potential anti-inflammatory and antioxidant properties by modulating the levels of TNF-α, IL-6 and antioxidant enzymes. Our study reveals a novel cardioprotective effect of PN in IMI rats through the Nrf2/HO-1 signaling.

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Cardioprotective Effect of Polymyxin‐B and Dantrolene Combination on Isoproterenol‐Induced Hypertrophic Cardiomyopathy in Rats, via Attenuation of Calmodulin‐Dependent Protein Kinase II

Shaikh

Bhatt

2022

Chemistry & Biodiversity

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Hypertrophic cardiomyopathy is a major cause of mortality worldwide. In this study, we hypothesized that the combination of Dantrolene and Polymyxin-B will provide cardioprotective action against isoproterenolinduced hypertrophic cardiomyopathy via attenuation of Calmodulin-dependent protein kinase II (CaMKII). Hypertrophic cardiomyopathy was induced in rats by subcutaneous administration of isoproterenol (5 mg/kg) for 14 days. Simultaneously, animals were treated with Polymyxin-B per se, Dantrolene per se, and Dantrolene and Polymyxin-B combination for 14 days. Hemodynamic parameters, biochemical parameters, and histological analysis were performed. Administration of isoproterenol for 14 days resulted in severe myocardial damage, characterized by cardiac hypertrophy and increase serum CK-MB, CK-Nac, LDH, AST, and ALT levels. It also caused alteration in electrocardiogram and blood pressure. A significant increase in CaMKII was observed in heart homogenate. Treatment with the Polymyxin-B and Dantrolene combination significantly ameliorated cardiac hypertrophy, biochemical parameters, ECG parameters, and heart histopathology. Further, significant attenuation in CaMKII levels was observed. The effect of the combination was more than per se treatment. Results of the current study showed that the combination of Polymyxin-B and Dantrolene prevented the development of isoproterenol-induced hypertrophic cardiomyopathy in rats via attenuation of the CaMKII.

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Attenuation of isoproterenol-induced cardiotoxicity in rats by Narirutin rich fraction from grape fruit

Cited by 24 publications

References 24 publications

(E)-N′-(1-(7-Hydroxy-2-Oxo-2H-Chromen-3-Yl) Ethylidene) Benzohydrazide, a Novel Synthesized Coumarin, Ameliorates Isoproterenol-Induced Myocardial Infarction in Rats through Attenuating Oxidative Stress, Inflammation, and Apoptosis

(E)-N′-(1-(7-Hydroxy-2-Oxo-2H-Chromen-3-Yl) Ethylidene) Benzohydrazide, a Novel Synthesized Coumarin, Ameliorates Isoproterenol-Induced Myocardial Infarction in Rats through Attenuating Oxidative Stress, Inflammation, and Apoptosis

Phikud Navakot Modulates the Level of Pro-Inflammatory Mediators and the Protein Expression of SOD1 and 2 and the Nrf2/HO-1 Signaling Pathway in Rats with Acute Myocardial Infarction

Cardioprotective Effect of Polymyxin‐B and Dantrolene Combination on Isoproterenol‐Induced Hypertrophic Cardiomyopathy in Rats, via Attenuation of Calmodulin‐Dependent Protein Kinase II

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