2010
DOI: 10.1016/j.biopsych.2010.07.003
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Atypical Default Network Connectivity in Youth with Attention-Deficit/Hyperactivity Disorder

Abstract: Background Attention deficit/hyperactivity disorder (ADHD) is a major public health concern. It has been suggested that the brain’s default network may provide a crucial avenue for understanding the neurobiology of ADHD. Evaluations of the default network have increased over recent years with the applied technique of resting-state functional connectivity MRI (rs-fcMRI). These investigations have established that spontaneous activity in this network is highly correlated at rest in young adult populations. This … Show more

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Cited by 326 publications
(296 citation statements)
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“…The field has produced inconsistent results in this regard. While most studies have reported reduced DMN connectivity [37,38,44,62], hyperconnectivity has also been observed [40,41] (and one study found hyperconnectivity for some regions and hypoconnectivity for others within the DMN [65]. These inconsistencies may be due to differences between studies in analysis techniques used or sample characteristics.…”
Section: Discussionmentioning
confidence: 99%
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“…The field has produced inconsistent results in this regard. While most studies have reported reduced DMN connectivity [37,38,44,62], hyperconnectivity has also been observed [40,41] (and one study found hyperconnectivity for some regions and hypoconnectivity for others within the DMN [65]. These inconsistencies may be due to differences between studies in analysis techniques used or sample characteristics.…”
Section: Discussionmentioning
confidence: 99%
“…This was done in order to be able to estimate overall network connectivity using a comprehensive approach, which is different from previous seed-based connectivity or network homogeneity studies. Moreover, the current sample included adults, while other studies with a comparable network approach that reported disconnection between DMN regions were conducted in adolescent samples [38,62]. The 15 finding of intra-DMN hyperconnectivity in our ADHD sample appears to be consistent with the concept of resting state affinity proposed as a potential mechanism behind problems in state-to-state switching [11], with hyper-connectivity within resting networks increasing affinity for that state and reducing the potential for switching to active goal directed states.…”
Section: Discussionmentioning
confidence: 99%
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“…For example, patients with ADHD exhibit altered functional connectivity at rest and during task performance. They also display reduced task-induced attenuation of VLF oscillations in regions linked to DMN (Castellanos et al, 2008;Fair et al, 2010;Fassbender et al, 2009;Liddle et al, 2011;Tian et al, 2008). In line with neuroimaging findings, studies with DC-EEG have found reduced resting state VLF EEG power in adolescents with ADHD, along with decreased rest-to-task attenuation of VLF EEG power compared to healthy age-matched volunteers (Helps et al, 2010).…”
Section: Introductionmentioning
confidence: 99%
“…ADHD adults [44,45] and in children with ADHD [46] . Besides, abnormalities in the inter-regional synchronization between the cognitive-attentional network and default network have been reported in ADHD patients [14,44] .…”
mentioning
confidence: 99%