Atypical retinal microvasculopathy after bone marrow transplantation

Bylsma, Guy; Hall, Anthony Jh; Szer, Jeffrey; West, Robert H.

doi:10.1046/j.1442-9071.2001.00423.x

Cited by 15 publications

(9 citation statements)

References 10 publications

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“…Atypical retinal microvasculopathy, without cotton-wool spots, has also been described. 21 Radiation may provoke an occlusive microangiopathy but only if the radiation dose exceeds 35 Gy. Thus, TBI alone cannot explain ischemic retinopathy in patients who have received a transplant, and additional factors, such as cyclosporine, may lower the threshold for radiation retinopathy.…”

Section: Late Ocular Effects Ocular Complications Of the Posterior Sementioning

confidence: 99%

Nonmalignant late effects after allogeneic stem cell transplantation

Socié

Salooja²,

Cohen³

et al. 2003

Blood

376

208

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Section: Late Ocular Effects Ocular Complications Of the Posterior Sementioning

confidence: 99%

Nonmalignant late effects after allogeneic stem cell transplantation

Socié

Salooja²,

Cohen³

et al. 2003

Blood

376

208

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“…IMR usually occurs within 6 months of allogeneic HCT, 52 although atypically late onset around 50 months after allogeneic HCT has been described in 4 patients. 54 Potential risk factors for IMR include TBI conditioning, 22,52,54 cyclosporine prophylaxis, 22,52 and conditioning regimens including busulfan or carmustine. 53,54…”

Section: Ischemic Microvascular Retinopathymentioning

confidence: 99%

Non-GVHD ocular complications after hematopoietic cell transplantation: expert review from the Late Effects and Quality of Life Working Committee of the CIBMTR and Transplant Complications Working Party of the EBMT

Inamoto¹,

Petriček

Burns

et al. 2019

Bone Marrow Transplant

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Non-graft-versus-host disease (non-GVHD) ocular complications are generally uncommon after hematopoietic cell transplantation (HCT), but can cause prolonged morbidity affecting activities of daily living and quality of life. Here we provide an expert review of non-GVHD ocular complications in a collaboration between transplant physicians and ophthalmologists through the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and the Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation. Complications discussed in this review include cataracts, glaucoma, ocular infections, ocular involvement with malignancy, ischemic microvascular retinopathy, central retinal vein occlusion, retinal hemorrhage, retinal detachment and ocular toxicities associated with medications. We have summarized incidence, risk factors, screening, prevention and treatment of individual complications and generated evidence-based recommendations. Baseline ocular evaluation before HCT should be considered in all patients who undergo HCT. Follow-up evaluations should be considered according to clinical symptoms, signs and risk factors. Better preventive strategies and treatments remain to be investigated for individual ocular complications after HCT. Both transplant physicians and ophthalmologists should be knowledgeable of non-GVHD ocular complications and provide comprehensive collaborative team care.

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“…In addition to the conditions herein described, other complications associated with poor visual acuity, which have not been observed in this case series, may occur after transplantation, including retinal microvasculopathy after bone marrow transplantation related to the use of immunosuppressive drugs; 20 - 23 tacrolimus-associated ischemic optic neuropathy; 24 , 25 tacrolimus-associated maculopathy; 26 optical nerve toxicity for cyclosporine; 27 and reversible posterior leukoencephalopathy syndrome related to the use of the immunosuppressants cyclosporine and tacrolimus 28 , 29 or to the use of immnosuppressants associated with vascular injury. 30 …”

Section: Discussionmentioning

confidence: 65%

Retinal changes in solid organ and bone marrow transplantation patients

Malerbi

Teixeira

Hirai

et al. 2017

Einstein (São Paulo)

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Objective To evaluate retinal changes in patients who underwent solid organ or bone marrow transplantation.Methods A retrospective analysis of medical records of patients evaluated from February 2009 to December 2016. All patients included underwent funduscopy. Clinical and demographic data regarding transplantation and ophthalmological changes were collected.Results A total of 126 patients were analyzed; of these, 108 underwent transplantation and 18 were in the waiting list. Transplantation modalities were heart, lung, kidney, liver, pancreas, combined pancreas and kidney and bone marrow transplantation. The main pre-transplantation comorbidities were diabetes and arterial hypertension. Of the 108 transplanted patients, 82 (76%) had retinal changes. All patients who underwent pancreas or combined pancreas and kidney transplantation had diabetic retinopathy. The main retinal changes found were diabetic retinopathy, hypertensive retinopathy, retinal vascular occlusions, chorioretinal infections and central serous chorioretinopathy.Conclusion Retinal changes were either related to preexisting conditions, mainly diabetic retinopathy, or developed postoperatively as a complication of the surgical procedure, or as an infection related to the immunosuppressive status, or due to drug toxicity. These patients may present with complex ophthalmological changes and should be carefully evaluated prior to surgery and further followed by an ophthalmologist skilled in the management of diabetic retinopathy and posterior pole infections.

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Atypical retinal microvasculopathy after bone marrow transplantation

Abstract: Retinal microvascular incompetence (without cotton wool spots) with good vision may occur in a small number of patients as a late complication of allogeneic BMT

Cited by 15 publications

References 10 publications

Nonmalignant late effects after allogeneic stem cell transplantation

Nonmalignant late effects after allogeneic stem cell transplantation

Non-GVHD ocular complications after hematopoietic cell transplantation: expert review from the Late Effects and Quality of Life Working Committee of the CIBMTR and Transplant Complications Working Party of the EBMT

Retinal changes in solid organ and bone marrow transplantation patients

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