Au coated Ni nanowires with tuneable dimensions for biomedical applications

Pondman, Kirsten M.; Maijenburg, A. Wouter; Celikkol, Burcu; Pathan, Ansar A.; Kishore, Uday; Haken, Bennie ten; Elshof, Johan E. ten

doi:10.1039/c3tb20808g

Cited by 42 publications

(35 citation statements)

References 35 publications

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“…On the other hand, magnetic nanoparticles, especially of iron oxides, are being used in biomedicine for treatment as hyperthermia or drug delivery [6][7][8][9]. Recently, the possibility of using nickel nanowires in biomedicine has been also proposed [10][11][12]. In the present work we propose the test of CoNi@Au nanorods (NRs), of a few microns of length, as magnetic supports that could be functionalized and show little cellular toxicity.…”

Section: Introductionmentioning

confidence: 94%

Electrochemical preparation and characterization of magnetic core–shell nanowires for biomedical applications

Gispert¹,

Serrà²,

Alea³

et al. 2016

Electrochemistry Communications

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Magnetic CoNi@Au core-shell nanorods have been electrochemically synthesized, characterized and functionalized to test their inherent cytotoxicity in order to assess their potential use for biomedical applications. The initially electrodeposited CoNi nanorods have been covered with a gold layer by means of galvanic displacement to minimize the nanowires toxicity and their aggregation, and favour the functionalization. The presence of a gold layer on the nanorod surface slightly modifies the magnetic behaviour of the as-deposited nanorods, maintaining their soft-magnetic behaviour and high magnetization of saturation. The complete covering of the nanorods with the gold shell favours a good functionalization with a layer of (11-Mercaptoundecyl)hexa(ethylene glycol) molecules, in order to create a hydrophilic coating to avoid the aggregation of nanorods, keeping them in suspension and give them stability in biological media. The presence of the organic layer incorporated was detected by means of electrochemical probe experiments. A cytotoxicity test of functionalized core-shell nanorods, carried out with adherent HeLa cells, showed that cell viability was higher than 80% for amounts of nanorods up to 10 μg mL −1 . These results make functionalized nanorods promising vehicles for targeted drug delivery in medicine, which gives a complementary property to the magnetic nanoparticles.

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Section: Introductionmentioning

confidence: 94%

Electrochemical preparation and characterization of magnetic core–shell nanowires for biomedical applications

Gispert¹,

Serrà²,

Alea³

et al. 2016

Electrochemistry Communications

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“…Similarly, short (2.6 μm) Aucoated Ni nanowires functionalized with polyethylene glycol and glutathione were internalized by macrophage RAW 264.7 cells, most likely via phagocytosis. 47 These nanowires showed good biocompatibility, as demonstrated by a comprehensive cell viability study carried out on several cell types. Non-coated Ni nanowires generally displayed higher cytotoxicity than AuNi nanowires; however, in this study the concentration of the Ni nanowires was much higher than the lethal concentration of similar 20 μm Ni nanowires, 42 indicating the importance of tailoring the length to increase the biocompatibility of such aspect ratio nanomaterials.…”

Section: Interaction Of High Aspect Ratio Magnetic Nanomaterials Withmentioning

confidence: 99%

“…Pondman et al synthesised short (2.6 ± 0.3 μm, 150 nm diameter) superparamagnetic Ni nanowires by electrodeposition inside polycarbonate membranes. 47 After dissolution of the membrane, the nanowires were further coated with a gold layer to increase their biocompatibility. Another methodology to construct high aspect ratio nanomaterials using hard templates consists in the vacuumassisted infiltration of the components in the pores of the template.…”

Section: Direct Synthesismentioning

confidence: 99%

Shape matters: synthesis and biomedical applications of high aspect ratio magnetic nanomaterials

2015

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High aspect ratio magnetic nanomaterials possess anisotropic properties that make them attractive for biological applications. Their elongated shape enables multivalent interactions with receptors through the introduction of multiple targeting units on their surface, thus enhancing cell internalization. Moreover, due to their magnetic anisotropy, high aspect ratio nanomaterials can outperform their spherical analogues as contrast agents for magnetic resonance imaging (MRI) applications. In this review, we first describe the two main synthetic routes for the preparation of anisotropic magnetic nanomaterials: (i) direct synthesis (in which the anisotropic growth is directed by tuning the reaction conditions or by using templates) and (ii) assembly methods (in which the high aspect ratio is achieved by assembly from individual building blocks). We then provide an overview of the biomedical applications of anisotropic magnetic nanomaterials: magnetic separation and detection, targeted delivery and magnetic resonance imaging.

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“…There are some requirements for protective layer such as absence of bioactivity, resistance to biodegradation, and stability, and it should have special functional groups to make links with payloads. These requirements satisfy organic (polymers) [21], inorganic (silane) [22], and gold coatings [23].…”

Section: Introductionmentioning

confidence: 99%

Comprehensive Study of Ni Nanotubes for Bioapplications: From Synthesis to Payloads Attaching

Kozlovskiy

Korolkov

Kalkabay

et al. 2017

Journal of Nanomaterials

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Due to the Ni nanotubes' shape anisotropy, low specific density, large specific surface, and uniform magnetic field, they have been offered as carriers for targeted delivery of drug or protein and the process of their formation from synthesis stage to the stage of surface modification and protein attaching has been demonstrated. Some steps to hasten their biomedical application have been applied. First, to have full control over the carrier dimensions and structure parameters, electrodeposition method in pores of polyethylene terephthalate template has been applied. Second, to understand the scope of Ni nanostructures application, their degradation in media with different acidity has been studied. Third, to improve the biocompatibility and to make payloads attachment possible, nanotubes surface modification with organosilicon compound has been carried out. At last, the scheme of protein attaching to the nanostructure surface has been developed and the binding process was demonstrated as an example of the bovine serum albumin.

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Au coated Ni nanowires with tuneable dimensions for biomedical applications

Cited by 42 publications

References 35 publications

Electrochemical preparation and characterization of magnetic core–shell nanowires for biomedical applications

Electrochemical preparation and characterization of magnetic core–shell nanowires for biomedical applications

Shape matters: synthesis and biomedical applications of high aspect ratio magnetic nanomaterials

Comprehensive Study of Ni Nanotubes for Bioapplications: From Synthesis to Payloads Attaching

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