Au-Fe2C Nanoparticle-Based Radiation Dose Enhancement

Abstract

tumors in BALB/c nude mice, the radiosensitizing effect of PD98059 was investigated in vivo. Results: Our study found the delayed xenograft tumor growth in PDAC was significantly inhibited by fractionated radiation, while reactivated after the radiotherapy ended, inducing tumor relapse. The Mek kinase inhibitor PD98059 significantly radiosensitized PDAC cell lines by enhancing DSBs and inhibiting DNA damage repair, resulting in decreased clonogenic survival and increased tumor growth inhibitory effect. In vivo studies showed PD98059 significanlty delayed xenograft tumor growth with decreased tumor weight and prolonged tumor growth delay time. Conclusion: Our study discovered targeting MAPK signaling pathway could significantly improve tumor radioresponse of PDAC.