Au nanozyme-driven antioxidation for preventing frailty

Kim, Jeonghyo; Oh, Sang-Jin; Shin, Yong Cheol; Wang, Cai‐Feng; Kang, Moon Sung; Lee, Jong Ho; Yun, Woobin; Cho, Jin Ah; Hwang, Dae Youn; Han, Dong‐Wook; Lee, Jaebeom

doi:10.1016/j.colsurfb.2020.110839

Cited by 11 publications

(7 citation statements)

References 40 publications

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“…[91][92][93][94] During the procedure for the disease therapeutic applications, the Au nanoparticles have been discovered possess the natural enzymes-like catalytic activity. [95][96][97][98] As one of the most important raw materials for fabrication of nanozyme, the Au have been well-studied as a result of their unique plasmonic features at the nanoscale. [99] The catalytic properties of Au nanozymes are key features with special interest for chemical or biological applications.…”

Section: Nanozyme Containing Single Metal Elementmentioning

confidence: 99%

Recent Advances in Nanozymes: From Matters to Bioapplications

Liang

et al. 2021

Adv Funct Materials

245

115

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The manufacture of bionic materials to simulate the natural counterparts has attracted extensive attention. As one of the subcategories of biomimetic materials, the development of artificial enzyme is intensive pursuing. As a kind of artificial enzyme, nanozymes are dedicated to solve the limitations of natural enzymes. In recent years, attributed to the explosive development of nanotechnology, biotechnology, catalysis science, computational design and theory calculation, research on nanozymes has made great progress. To highlight these achievements and help researchers to understand the current investigation status of nanozyme, the state‐of‐the‐art development in nanozymes from fabrication materials to bioapplications are summarized. First different raw materials are summarized, including metal‐based, metal‐free, metal‐organic frameworks‐based, and some other novel matters, which are applied to fabricate nanozymes. The different types of enzymes‐like catalytic activities of nanozymes are briefly discussed. Subsequently, the wide applications of nanozymes such as anti‐oxidation, curing diseases, anti‐bacteria, biosensing, and bioimaging are discussed. Finally, the current challenges faced by nanozymes are outlined and the future directions for advancing nanozyme research are outlooked. The authors hope this review can inspire research in the fields of nanotechnology, chemistry, biology, materials science, and theoretical computing, and can contribute to the development of nanozymes.

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Section: Nanozyme Containing Single Metal Elementmentioning

confidence: 99%

Recent Advances in Nanozymes: From Matters to Bioapplications

Liang

et al. 2021

Adv Funct Materials

245

115

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“…In the osseointegration dental implant study, imprinted Au-chitosan hybrid nanoconjugate (Ch-GNPs/c-myb) promoted osteogenesis and inhibited osteoclastogenesis in the ovariectomized rat model by overexpressing the bone morphogenetic proteins, osteoprotegerin, and EphB4, and downregulating RANKL proteins . Hexagon-shaped AuNPs (20 nm in diameter) synthesized using a mixture of gallic acid and isoflavone can effectively prevent senescence in neonatal human dermal fibroblasts, and oxidative stress in mice . These GNS exhibit the enzyme-like properties of superoxide dismutase.…”

Section: Therapeutic Applications Of Aunpsmentioning

confidence: 99%

“…38 Hexagon-shaped AuNPs (20 nm in diameter) synthesized using a mixture of gallic acid and isoflavone can effectively prevent senescence in neonatal human dermal fibroblasts, and oxidative stress in mice. 175 These GNS exhibit the enzyme-like properties of superoxide dismutase.…”

Section: Therapeutic Applications Of Aunpsmentioning

confidence: 99%

Delineating the Role of Tailored Gold Nanostructures at the Biointerface

Fatrekar

Morajkar

Krishnan

et al. 2021

ACS Appl. Bio Mater.

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Gold (Au) has emerged as a superior element, because of its widespread applications in electronic and medical fields. The desirable physical, chemical, optical, and inherent enzyme-like properties of Au are efficiently exploited for detection, diagnostic, and therapeutic purposes. Au offers a unique advantage of fabricating gold nanostructures (GNS) having exact physical, chemical, optical, and enzyme-like properties required for the specific biomedical application. In this Review, the emerging trend of GNS for various biomedical applications is highlighted. Some notable structural and chemical modifications achieved for the detection of biomolecules, pathogens, diagnosis of diseases, and therapeutic applications are discussed in brief. The limitations of GNS during biomedical usage are highlighted and the way forward to overcome these limitations are discussed.

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“…When the body’s metabolic and antioxidant defense mechanisms are slowed down or problematic due to aging or pathological conditions, with a decrease in endogenous enzymes, more ROS is produced than can be eliminated by endogenous enzymes. Therefore, an increase in inflammatory cytokines by ROS can lead to chronic inflammation, which increases the risk of various diseases [ 15 ]. Therefore, it is important to balance ROS levels by appropriate regulation.…”

Section: Introductionmentioning

confidence: 99%

Surface-mediated high antioxidant and anti-inflammatory effects of astaxanthin-loaded ultrathin graphene oxide film that inhibits the overproduction of intracellular reactive oxygen species

2022

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Background Astaxanthin (AST) is known as a powerful antioxidant that affects the removal of active oxygen and inhibits the production of lipid peroxide caused by ultraviolet light. However, it is easily decomposed by heat or light during production and storage because of the unsaturated compound nature with a structural double bond. The activity of AST can be reduced and lose its antioxidant capability. Graphene oxide (GO) is an ultrathin nanomaterial produced by oxidizing layered graphite. The chemical combination of AST with GO can improve the dispersion properties to maintain structural stability and antioxidant activity because of the tightly bonded functionalized GO surface. Methods Layered GO films were used as nanocarriers for the AST molecule, which was produced via flow-enabled self-assembly and subsequent controlled solution deposition of RGD peptide and AST molecules. Synthesis of the GO-AST complex was also carried out for the optimized concentration. The characterization of prepared materials was analyzed through transmission electron microscopy (TEM), scanning electron microscope (SEM), Fourier-transform infrared spectroscopy (FT-IR), atomic force microscope (AFM), and Raman spectroscopy. Antioxidant activity was tested by 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and 2.2-diphenyl-1-picrylhydrazyl (DPPH) assays. The antibacterial effect and antioxidant effects were monitored for the ultrathin GO/RGD/AST Film. Further, reactive oxygen species (ROS) assay was used to evaluate the anti-inflammatory effects on L-929 fibroblasts. Results Cotreatment of GO-AST solution demonstrated a high antioxidant combined effect with a high ABTS and DPPH radicals scavenging activity. The GO/RGD/AST film was produced by the self-assembly process exhibited excellent antibacterial effects based on physicochemical damage against E. coli and S. aureus. In addition, the GO/RGD/AST film inhibited H2O2-induced intracellular ROS, suppressed the toxicity of lipopolysaccharide (LPS)-induced cells, and restored it, thereby exhibiting strong antioxidant and anti-inflammatory effects. Conclusion As GO nanocarrier-assisted AST exerted promising antioxidant and antibacterial reactions, presented a new concept to expand basic research into the field of tissue engineering.

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Au nanozyme-driven antioxidation for preventing frailty

Cited by 11 publications

References 40 publications

Recent Advances in Nanozymes: From Matters to Bioapplications

Recent Advances in Nanozymes: From Matters to Bioapplications

Delineating the Role of Tailored Gold Nanostructures at the Biointerface

Surface-mediated high antioxidant and anti-inflammatory effects of astaxanthin-loaded ultrathin graphene oxide film that inhibits the overproduction of intracellular reactive oxygen species

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