Auden and Shakespeare

Regan, Stephen

doi:10.1017/cbo9781139018180.031

Cited by 4 publications

(6 citation statements)

References 1 publication

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“…The relevance of the potassium ion to the occurrence of lethal ventricular arhythmias soon after the production of acute myocardial ischaemia has been the subject of a number of experimental studies. Some authors have deduced a causal relationship between cumulative potassium loss and the incidence of ventricular arrhythmias in the early stages of experimental myocardial infarction (Harris, Bisteni, Russell, Brigham & Firestone, 1954;Regan, Harman, Lehan, Burke & Oldewurtel, 1967) while others have failed to show any relationship (Wexler & Patt, 1960;Thomas et al, 1970).…”

Section: Discussionmentioning

confidence: 99%

ANTIARRHYTHMIC, HAEMODYNAMIC AND METABOLIC EFFECTS OF 3α‐AMINO‐5α‐ANDROSTAN‐2β‐OL‐17‐ONE HYDROCHLORIDE IN GREYHOUNDS FOLLOWING ACUTE CORONARY ARTERY LIGATION

Marshall

Parratt

1975

British J Pharmacology

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1The antiarrhythmic, haemodynamic and metabolic effects of a new amino steroid, ORG6001, have been investigated in experimental acute myocardial infarction in anaesthetized greyhounds. 2 ORG6001 administered either intravenously (1-10 mg/kg) or orally (50 mg/kg) significantly reduced the incidence of ventricular ectopic beats in the first 30 min after ligation of the left anterior descending coronary artery. 3 In dogs pretreated with ORG600 1, metabolic changes indicative of myocardial ischaemia (lactate production and potassium efflux) were less marked than those occurring in control animals. 4 Antiarrhythmic doses of ORG6001 caused only minimal transient haemodynamic effects. 5 These results suggest that ORG6001 may possess distinct advantages over presently-used antiarrhythmic drugs in the prevention and treatment of the early arrhythmias which occur after myocardial infarction.

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Section: Discussionmentioning

confidence: 99%

ANTIARRHYTHMIC, HAEMODYNAMIC AND METABOLIC EFFECTS OF 3α‐AMINO‐5α‐ANDROSTAN‐2β‐OL‐17‐ONE HYDROCHLORIDE IN GREYHOUNDS FOLLOWING ACUTE CORONARY ARTERY LIGATION

Marshall

Parratt

1975

British J Pharmacology

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“…A significant reduction in the density of PBS in rat kidney following adrenalectomy has been reported (Basile et al, 1985), reversible by aldosterone but not by dexamethasone. Increases in the density of PBS in rat kidney occur following prolonged progesterone and thyroxine treatment (Gavish et a/., 1986(Gavish et a/., , 1987 and in kidneys of deoxycorticosterone/salt-hypertensive rats (Regan et al, 1981) as well as those of the Brattleboro rat, an animal model of diabetes insipidus (Del Zompo et al, 1984). However, a decrease in platelet and renal PBS has been observed in spontaneously hypertensive rats compared with controls (Taniguchi tlt al., 1981).…”

Section: Discussionmentioning

confidence: 99%

“…Although the exact function of PBS has not yet been fully determined, evidence suggests that they play a role in cardiac function (Mestre et al, 1984), in the pathogenesis of hypertension (Taniguchi et a/., 1981) and in renal water and salt balance (Regan et al, 1981;Del Zompo et al, 1984). PBS have been identified in cultures of normal and malignant cell lines, and the presence of BZ ljgands in the medium can modulate the proliferative, differentiative and intracellular processes of the cultured cells (Clark and Ryan, 1980;Wang et al, 1984).…”

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confidence: 99%

Absence of Peripheral‐type Benzodiazepine Binding Sites in Renal Carcinoma: a Potential Biochemical Marker

Katz

Moskovitz

Levin

et al. 1989

British Journal of Urology

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In an attempt to identify a tumour marker, we investigated peripheral-type benzodiazepine binding sites (PBS) in kidney specimens obtained from patients who underwent nephrectomy due to a renal mass. [3H]PK 11195, an isoquinoline carboxamide derivative, was used as a ligand. Binding assays were conducted on samples of membrane homogenate taken from both the healthy portion and the tumour site of the kidney. It was found that binding characteristics of benign tumours and normal kidney tissues were not significantly different, i.e. equilibrium dissociation constants of 2.20 +/- 0.73 and 2.38 +/- 0.98 nM, respectively, and maximal number of binding sites of 3190 +/- 1081 and 4189 +/- 998 fmol/mg protein, respectively. In contrast, no PBS were detectable in renal carcinoma. The absence of PBS in malignant renal tissues may serve as a biochemical marker for tumours of the kidney.

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“…One class of these pollutants includes organic dyes, typically highly pigmented organic compounds used in a number of industries including textiles, leather, paper, cosmetics, and food. Over 100,000 different dyes have been synthesized, and more than 0.7 million tons are produced annually. , Any effluent discharged by the textile industry is a major polluter and source of dyes released into the environment, as dyes are lost to the environment at every step of the process, from manufacture (10–15%) to application (20–30%). , …”

Section: Introductionmentioning

confidence: 99%

Controlled Removal of Organic Dyes from Aqueous Systems Using Porous Cross-Linked Conjugated Polyanilines

Maxwell

Baker

Faul

2022

ACS Appl. Polym. Mater.

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Porous organic materials, as a broad class of functional materials, offer a promising route for low-cost purification of contaminated wastewaters. We have synthesized a range of highly cross-linked conjugated porous polyanilines and optimized their porosity and water dispersibility by tuning reactant feed ratios, previously unreported in the synthesis of such networks. To demonstrate their ability to adsorb model dyes used in the textile industry, we exposed the networks to a range of cationic aromatic dyes, leading to absorption capacities of >100 mg/g, reported for the first time with respect to polyaniline networks. The versatility of the networks was further demonstrated by the preparation of gel composites, producing active gels for efficient and facile removal and recycling, ideal for real-world applications. Finally, chemical modifications of the networks were undertaken to target the removal of model anionic organic dye pollutants, showing the wide applicability of our approach.

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Auden and Shakespeare

Cited by 4 publications

References 1 publication

ANTIARRHYTHMIC, HAEMODYNAMIC AND METABOLIC EFFECTS OF 3α‐AMINO‐5α‐ANDROSTAN‐2β‐OL‐17‐ONE HYDROCHLORIDE IN GREYHOUNDS FOLLOWING ACUTE CORONARY ARTERY LIGATION

ANTIARRHYTHMIC, HAEMODYNAMIC AND METABOLIC EFFECTS OF 3α‐AMINO‐5α‐ANDROSTAN‐2β‐OL‐17‐ONE HYDROCHLORIDE IN GREYHOUNDS FOLLOWING ACUTE CORONARY ARTERY LIGATION

Absence of Peripheral‐type Benzodiazepine Binding Sites in Renal Carcinoma: a Potential Biochemical Marker

Controlled Removal of Organic Dyes from Aqueous Systems Using Porous Cross-Linked Conjugated Polyanilines

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