Audiological findings in patients treated with radio- and concomitant chemotherapy for head and neck tumors

Dell'Aringa, Ana Helena Bannwart; Isaac, Myrian L; Arruda, Gustavo Viani; Esteves, Maria Carolina B. N.; Dell’Aringa, Alfredo Rafael; Júnior, José Luis S; Rodrigues, Alexandre F

doi:10.1186/1748-717x-4-53

Cited by 24 publications

(36 citation statements)

References 13 publications

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“…Electrons are displaced in cancer tissues, by ionization, cause chemical and biological effects, such as DNA damage, that prevent the replication of neoplastic cells. It acts directly on the tumors and stops their multiplication by mitosis and/or determine cell death [3,6,14]. The literature also evince that chemoradiotherapy improves patient survival [15,16], but our participants had advanced cases and medical team reported the radiation therapy as an efficient procedure in cancer treatment.…”

Section: Resultsmentioning

confidence: 99%

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Effects in Hearing Thresholds in Subjects Receiving Radiotherapy as Treatment for Head and Neck Cancer

Oliveira¹,

Santos²,

Carneiro³

et al. 2017

Otolaryngol (Sunnyvale)

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Section: Resultsmentioning

confidence: 99%

“…Cancer treatment has ototoxic effects that can damage hair cells, so it initially affects high frequencies, and it can also endanger low frequencies as a result of treatment exposure [3,5,14]. Literature reports an incidence of 26% and 85% of hearing loss, once 95% of hearing losses are sensorioneural [6].…”

Section: Controlmentioning

confidence: 99%

Effects in Hearing Thresholds in Subjects Receiving Radiotherapy as Treatment for Head and Neck Cancer

Oliveira¹,

Santos²,

Carneiro³

et al. 2017

Otolaryngol (Sunnyvale)

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“…SNHL was observed in 43.33 % of patients and 16.67 % had mixed hearing loss 6 months post treatment. Dell'Aringa et al [14] observed that 17 patients with extra cranial head and neck malignancies included in the study presented with auditory damage with 70.5 % of them with having auditory alteration; 55.8 % with change higher than 20 dB in a unique frequency and 14.7 % with reduction of 10 dB in at least two consecutive frequencies. However, in the present study at the end of 16 weeks, 72.5 and 82.5 % of patients had SNHL at 4 and 8 kHz frequencies respectively which was clearly much above than the previous two studies.…”

Section: Discussionmentioning

confidence: 99%

Effects of Chemoradiation on Hearing in Patients with Head and Neck Malignancies: Experience at a Tertiary Referral Care Hospital

Jain¹,

Banerjee²,

Dandinarasaiah

2016

Indian J Otolaryngol Head Neck Surg

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Hearing loss as a side effect in patients with head and neck malignancies with chemoradiation is frequently ignored. Its effects on auditory functions are less studied and there are studies done on animals which are less reliable. The present study was undertaken to identify the type of hearing loss and also to quantify the degree of hearing loss in these patients. A prospective, descriptive study was undertaken in histologically proven head and neck cancer patients treated with cobalt 60 teletherapy who received a dose of 60-66 Grays (Gy) over a period of 6-7 weeks with concurrent Cisplatin 30 mg/m 2 once weekly for 6 weeks. The study included 40 patients (80 ears) undergoing chemoradiation. A baseline pure tone audiometry and impedance audiometry was performed in all the cases prior to the therapy and the same was repeated immediately after the completion of treatment, at 8 and 16 weeks. The changes in pure tone level thresholds and impedance from baseline were correlated with the dose of radiation and chemotherapy. Sensori neural hearing loss (SNHL) and conductive hearing loss was observed in 82.5 and 17.5 % respectively. At the end of 16 weeks, SNHL was found in 27.5, 72.5 and 82.5 % at 2, 4 and 8 kHz respectively. In addition, Eustachian tube dysfunction and Otitis media with effusion was observed in 10 and 7.5 % of patients respectively which lead to conductive hearing loss. Further, it was noted that SNHL in patients with high risk site malignancy (81.8 %) was alarmingly higher compared with low risk site malignancy (18.1 %). The hearing loss at 62, 64 and 66 Gy in comparison to 60 Gy was statistically significant. Hearing loss, specially SNHL was the predominant finding in our study with [80 % of patients showing the inner ear damage due to irradiation of head and neck malignancies. Although, all the frequencies like 2, 4 and 8 kHz were significantly affected, SNHL was more marked in the latter two frequencies. Nearly, 90 % of the patients who had SNHL belonged to high risk site category of head and neck malignancies. Increasing the radiation dosage was directly proportional to the degree of hearing loss with the dose more than 60 Gy causing significant injury to the middle and inner ear.

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“…Generally, hearing loss is sensorineural, bilateral and irreversible, tends to be permanent and it has tinnitus as a symptom [3,4]. It is a result of ototoxicity, which can damage cochlea`s basal turn and hits outer hair cells, before some days or weeks after cancer treatment [5].…”

Section: Introductionmentioning

confidence: 99%

“…Hearing loss affects either communication, social and emotional aspects; it may furhter reduce quality of life. Moreover, investigators have described hearing loss during cancer treatment, which can became worse (75% up to a 100%) especially in higher frequencies [3,5]. Audiological procedure, as conventional pure tone audiometry, is the basic of audiological battery for hearing loss diagnostic, once ototoxicity can develop a high frequency damage [6].…”

Section: Introductionmentioning

confidence: 99%

Cancer treatment: changes in hearing thresholds

Machado¹,

Amaral²,

Aguiar³

et al. 2018

Oncol Res Rev

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Purpose: Evaluate changes in hearing thresholds in patients undergoing cancer treatment.Method: Prospective, longitudinal study carried out at Cancer Center of a Sergipe´s public hospital, Brazil. Audiological evaluation (Conventional Pure Tone Audiometry) have been performed in 20 patients following eight weeks of cancer treatment (reference exam) and 20 weeks (sequential exam) of treatment. All survivors had normal hearing thresholds before cancer treatment. The procedure has been approved by the Ethics in Research Committee, under protocol # 33665014.7.0000.5546.Results: Head and neck cancer displayed oncology highest incidence (35%). Referential exam, eight weeks before treatment, displayed 15% with sensorineural hearing loss and 17.5% at second tests. It was observed a slight worsening for all test frequencies of referential and sequential exam. Tinnitus was the biggest complaint (81.3%), but there was no statistic correlation between hearing loss (p=0.89). Conclusion:Hearing monitoring form this small sample suggest chemotherapy and radiotherapy treatments can have a detrimental effect on hearing thresholds significate for 2 to 8kHz eight weeks after cancer treatment and 4 to 8kHz 20 weeks before.

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Audiological findings in patients treated with radio- and concomitant chemotherapy for head and neck tumors

Cited by 24 publications

References 13 publications

Effects in Hearing Thresholds in Subjects Receiving Radiotherapy as Treatment for Head and Neck Cancer

Effects in Hearing Thresholds in Subjects Receiving Radiotherapy as Treatment for Head and Neck Cancer

Effects of Chemoradiation on Hearing in Patients with Head and Neck Malignancies: Experience at a Tertiary Referral Care Hospital

Cancer treatment: changes in hearing thresholds

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