Audiometric studies in type 2 diabetes mellitus

Abstract

Introduction: Hearing defects can cause inconvenience in communication which can have prodigious impact on the psychological, social and emotional functions. The increasing incidence of diabetes and profound effect of hearing loss on quality of life mandates the need to study the possible association between the two. Materials and method: An observational study was conducted including 100 participants such that 50 were non-diabetic (group A) and another 50 were diabetic. The participants of two groups were matched for age and gender. The Random Blood Sugar, HbA1c, Pure Tone Audiometry were assessed. The statistical analysis of data was done using SPSS (Statistical Package for Social Sciences) 21.0 version, IBM, Chicago. Results: The median age of the participants belonging to group A and B was 39.0 years and 40.0 years respectively. No significant association was observed between the presence or absence of diabetes and hearing loss (Chi-square value- 2.1, df-3, p value>.05). Amongst the patients with diabetes, the HbA1c level was found to have no significant association with the severity of hearing loss (Chi-square value- 9.243, df-4, p value>.05). Conclusion: It was concluded that there is no significant difference in hearing loss amongst the persons with and without diabetes.

An Experimental Models (In-Vivo and In-Vitro) Used for the Study of Antidiabetic agents

“…Insulin Antibodies Induced Diabetes Anti-insulin antibodies have an affinity and ability to bind insulin The mechanism of insulin deficiency can lead to greater postprandial hyperglycemia because antibody-bound insulin is not available to tissues, but prolonged postprandial hyperinsulinemia can lead to hyperglycemia [17][18].…”

Effectiveness of Using Gum Arabic for Co-Microencapsulation of Ruellia tuberosa L. and Tithonia diversifolia Extracts as Encapsulating Agent and Release Studies

“…Diabetes mellitus is a metabolic disorder characterized by the body's inability to produce or respond to insulin properly, so it cannot regulate blood sugar levels at normal levels [1]. Based on data from the International Diabetes Federation (IDF), the prevalence of type 2 diabetes mellitus (T2DM) jumped from 7.3 million in 2009 to 10.3 million in 2017 [2].…”

Kontrol Glikemik terhadap Kadar Profil Lipid pada Pasien DM Tipe 2

“…Kelainan lipid serum (dislipidemia) umumnya terlihat pada populasi diabetes terlepas dari defisiensi insulin atau resistensi insulin. Pasien diabetes melitus tipe 2 rentan terhadap dislipidemia diabetik, sehingga terdapat peningkatan risiko terjadinya komplikasi penyakit kardiovaskuar (Chung et al, 2020;Kumar et al, 2020;Marušić et al, 2021) Hasil penelitian (Yudha et al, 2021) mengenai hubungan antara HbA1c dan profil lipid pada pasien DM menunjukkan bahwa HbA1c berkaitan dengan kadar trigliserida, namun tidak didapatkan hubungan yang signifikan pada kolesterol total, K-LDL, dan K-HDL. Menurut Yuliana & Saldy (2021) Pasien DM tipe 2 dengan kontrol glikemik yang terkendali memiliki kadar kolesterol total, trigliserida, dan K-LDL yang lebih rendah secara signifikan jika dibandingkan dengan pasien DM tipe 2 dengan kontrol glikemik yang tidak terkendali Rutin melakukan kontrol gula darah merupakan salah satu upaya pencegahan yang dapat dilakukan oleh pasien DM.…”