Audit of Cancer Patients from Eastern Uttar Pradesh (UP), India: A University Hospital Based Two Year Retrospective Analysis

Nandi, Moujhuri; Mandal, Abhijit; Asthana, Anjana

doi:10.7314/apjcp.2013.14.9.4993

Cited by 13 publications

(11 citation statements)

References 9 publications

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“…The availability of detailed treatment records makes it possible to describe the integrity of treatment delivery in routine practice. Records of chemotherapy or radiation administration can describe dose intensity and completion rates that can be compared with those recommended in RCTs and practice guidelines 73,74 . Pathology records can offer insight into the quality of surgical care and provide data to drive quality improvement 75 .…”

Section: Quality Of Derived Variablesmentioning

confidence: 99%

Real-world data: towards achieving the achievable in cancer care

2019

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The use of data from the real world to address clinical and policy-relevant questions that cannot be answered using data from clinical trials is garnering increased interest. Indeed, data from cancer registries and linked treatment records can provide unique insights into patients, treatments and outcomes in routine oncology practice. In this Review , we explore the quality of real-world data (RWD), provide a framework for the use of RWD and draw attention to the methodological pitfalls inherent to using RWD in studies of comparative effectiveness. Randomized controlled trials and RWD remain complementary forms of medical evidence; studies using RWD should not be used as substitutes for clinical trials. The comparison of outcomes between nonrandomized groups of patients who have received different treatments in routine practice remains problematic. Accordingly , comparative effectiveness studies need to be designed and interpreted very carefully. With due diligence, RWD can be used to identify and close gaps in health care, offering the potential for short-term improvement in health-care systems by enabling them to achieve the achievable.

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Section: Quality Of Derived Variablesmentioning

confidence: 99%

Real-world data: towards achieving the achievable in cancer care

2019

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“…The Indian Cancer registry derives its data mainly from the metropolitan cities of the country which register a more urbane population. Selective reports from rural pockets of India (Mehrotra et al, 2008;Swaminathan et al, 2009;Manoharan et al, 2010;Nandi et al, 2013) have all reported cervix to be the leading cancer site in the country followed closely by the breast. The scenario will soon change as all the registries show an increasing trend in the percentage of breast cancer cases to the total number of cancer cases registered over the years.…”

Section: Indiamentioning

confidence: 99%

Hypofractionated Radiotherapy for Breast Cancers - Preliminary Results from a Tertiary Care Center in Eastern India

Nandi

Mahata²,

Mallick³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: The standard radiotherapy (RT) fractionation in breast cancers practised in India and worldwide is 50Gy in 25 fractions over 5 weeks to the chest wall or whole breast followed by tumour bed boost in case of breast conservation (BCS). A body of validated data exists regarding hypofractionation in breast cancer. We here report initial results for 135 patients treated at our centre with the START-B type of fractionation. Materials and Methods: From May 2011 till July 2012, women with all stages of breast cancer (excluding metastatic), who had undergone BCS or mastectomy were planned for 40Gy in 15 fractions over 3weeks to chest wall/whole breast and supraclavicular fossa (where indicated) followed by tumour bed boost in BCS patients. Planning was done using Casebow's technique. The primary end point was to assess the acute toxicity and the cosmetic outcomes. Using cosmetic scales; patients were assessed during radiotherapy and at subsequent follow up visits with the radiation oncologist. Results: Of the 135 patients, 62 had undergone BCS and 73 mastectomy. Mean age of the population was 52 years. 80% were T1&T2 tumours in BCS group whereas most patients in mastectomy group had T3&T4 tumours (60%). 45% were node negative in BCS group whilst it was 23% in the mastectomy group. Average NPI scores were 3.9 and 4.9, respectively. Most frequently reported histopathology and 30% were Her 2 Neu positive. Triple negative tumours accounted for 13% and their mean age was younger than the general population (43 yrs.) The maximum acute skin toxicity at the end of treatment was Grade 1 in 94% of the mastectomy group of patients and 71% in BCS patients. Grade 2 toxicity was 6% in mastectomy group and 23% in BCS group. Grade 3 was 6% in BCS group, no grade 3 toxicity in mastectomy patients and there was no grade 4 skin toxicity in any case. Post RT at 1 month; 39% of BCS patients had persisting Grade I skin reaction which was only 7% in mastectomy patients. At 3 months post RT, 18% patients had persisting hyperpigmentation. At 6 months 8% patients had persisting erythema in the BCS group only. 3% of BCS and 8% of mastectomy patients had lymph edema till the date of evaluation. Cosmetic outcome in BCS patients remained good to excellent 6 months post surgery and radiotherapy. 1 patient of BCS and 3 patients of mastectomy had developed metastatic disease at the time of evaluation. Conclusions: Hypofractionated RT is well tolerated in Indian population with less acute skin toxicity and good cosmetic outcome. Regimens such as these should be encouraged in other centre to increase machine output time. The study is on-going to assess long term results.

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“…Most common cancer among males was head-and-neck cancer while cervix and breast cancer were common among females. [6] Another study by Ghosh et al . of 2058 patients over 3-year period demonstrated similar findings of head-and-neck cancer being most common followed by breast and cervical cancer.…”

Section: Discussionmentioning

confidence: 99%

Cancer trends in Eastern India: Retrospective hospital-based cancer registry data analysis

Pandey

Raj

Madhawi

et al. 2019

South Asian J Cancer

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Background:Trends of cancer cases vary across several hospital-based cancer registries (HBCRs). There is a paucity of demographic data to evaluate trends of cancer in Eastern India.Aim:The aim of this study is to evaluate trends and pattern of cancer cases with respect to time from HBCR from Bihar.Objectives:The objective of this study is to evaluate the numbers of consecutive patients registered with eight most common type of cancer in our HBCR in Regional Cancer Centre, Bihar, and to evaluate trends of cancer cases registered with respect to time.Materials and Methods:Demographic profile of consecutive cancer patients registered from January 2014 to December 2016 (3 years) in HBCR was obtained. Patients diagnosed with common malignancies including head-and-neck cancer, gallbladder, breast, cervix, ovary, esophagus, stomach, hematolymphoid, and colorectal were analyzed. Frequency distribution, crosstabs, and line diagram were used to evaluate the trends of these common cancers with respect to time.Results:Sixty-six thousand and twenty-nine consecutive patients were registered between 2014 and 2016. Carcinoma gallbladder was the most common malignancy (21%), followed by head-and-neck cancer (19%) and breast cancer (15%). Median age at the diagnosis was 55 years for carcinoma gallbladder while 53 years and 46 years for head-and-neck and breast cancer, respectively. Male-to-female ratio was 0.6 for carcinoma gallbladder and 1.8 for head-and-neck cancer. A number of gallbladder and head-and-neck cancer registered increased by 36% (between 2014 and 2015) and 5% (between 2015 and 2016) and 24% (between 2014 and 2015) and 4% (between 2015 and 2016), respectively. Carcinoma breast and cervix showed decreasing trend with fall in registration up to 13% (between 2015 and 2016) and 27% (between 2015 and 2016), respectively.Conclusion:Carcinoma gallbladder is the most common cancer in Bihar. Head-and-neck cancer and carcinoma gallbladder are increasing while breast and cervical cancers are decreasing with respect to time.

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Audit of Cancer Patients from Eastern Uttar Pradesh (UP), India: A University Hospital Based Two Year Retrospective Analysis

Cited by 13 publications

References 9 publications

Real-world data: towards achieving the achievable in cancer care

Real-world data: towards achieving the achievable in cancer care

Hypofractionated Radiotherapy for Breast Cancers - Preliminary Results from a Tertiary Care Center in Eastern India

Cancer trends in Eastern India: Retrospective hospital-based cancer registry data analysis

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