Auditory brainstem response in pediatric migraine: During the attack and asymptomatic period

Fırat, Yezdan; Özturan, Orhan; Biçak, Uğur; Yakıncı, Cengiz; Akarçay, Mustafa

doi:10.1016/j.ijporl.2006.02.013

Cited by 15 publications

(7 citation statements)

References 29 publications

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“…This study provides evidence that the later BAEP peak latencies increase in a rat CS model upon auditory stimulation, changes consistent with findings in migraine (Bussone et al, 1985;Firat et al, 2006;Kochar et al, 2002). At 8 KHz stimulation, the later PLs (vPL4-6) and IPLs (IPLs from vN1 to vP4-6 or IPLs of vP3 to vP4, vP3 to vP6) increase 2–4 hours after NTG injection, corresponding with the time of the allodynia from von -Frey hair testing, increased cFos expression in the TCC, and cranial sodium elevation in this rat CS model (Harrington et al, 2011;Tassorelli et al, 1996;Tassorelli et al, 2005).…”

Section: Discussionsupporting

confidence: 91%

“…The interictal sound aversion threshold for 1000, 4000, and 8000 Hz stimulation was significantly lower than that of controls and decreased further during ictal migraine (Ashkenazi et al, 2009). BAEPs are altered in migraine, especially the later PL5 and IPL P1 to P5 (Bussone et al, 1985;Firat et al, 2006;Kochar et al, 2002). Clinical studies of short and long-latency auditory EPs indicate that phonophobia may be more dependent on brainstem than cortical mechanisms: results suggested a subcortical pontomesencephalic involvement as indicated by the later BAEP wave changes in migraine (Sand and Vingen, 2000).…”

Section: Discussionmentioning

confidence: 99%

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Altered brainstem auditory evoked potentials in a rat central sensitization model are similar to those in migraine

Arakaki¹,

Galbraith²,

Pikov³

et al. 2014

Brain Research

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Migraine symptoms often include auditory discomfort. Nitroglycerin (NTG)-triggered central sensitization (CS) provides a rodent model of migraine, but auditory brainstem pathways have not yet been studied in this example. Our objective was to examine brainstem auditory evoked potentials (BAEPs) in rat CS as a measure of possible auditory abnormalities. We used four subdermal electrodes to record horizontal (h) and vertical (v) dipole channel BAEPs before and after injection of NTG or saline. We measured the peak latencies (PLs), interpeak latencies (IPLs), and amplitudes for detectable waveforms evoked by 8, 16, or 32 KHz auditory stimulation. At 8 KHz stimulation, vertical channel positive PLs of waves 4, 5, and 6 (vP4, vP5, and vP6), and related IPLs from earlier negative or positive peaks (vN1-vP4, vN1-vP5, vN1-vP6; vP3-vP4, vP3-vP6) increased significantly 2 hours after NTG injection compared to the saline group. However, BAEP peak amplitudes at all frequencies, PLs and IPLs from the horizontal channel at all frequencies, and the vertical channel stimulated at 16 and 32 KHz showed no significant/consistent change. For the first time in the rat CS model, we show that BAEP PLs and IPLs ranging from putative bilateral medial superior olivary nuclei (P4) to the more rostral structures such as the medial geniculate body (P6) were prolonged 2 hours after NTG administration. These BAEP alterations could reflect changes in neurotransmitters and/or hypoperfusion in the midbrain. The similarity of our results with previous human studies further validates the rodent CS model for future migraine research.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Altered brainstem auditory evoked potentials in a rat central sensitization model are similar to those in migraine

Arakaki¹,

Galbraith²,

Pikov³

et al. 2014

Brain Research

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show abstract

“…In the present study, interpeak latencies of wave I-III & I-V is prolonged, but no prolongation is observed in interpeak latency of wave III-V. This result is supported by the results of previous studies in which interpeak latency of wave I-V was prolonged during the attack (Firat Y. et al, 2006). Similar results were obtained in another study in which prolongation of interpeak latencies I-III, III-V, I-V were reported in migraine patients (BayazitY, 2001).…”

Section: Figuresupporting

confidence: 92%

“…The side of latency prolongation was not affected by the side of headache. When these parameters were separately compared for gender, they were prolonged in boys during the attack in migraineurs; however in girls, while there was statistically significant difference at interpeak latencies of I-V, no significant difference was noted at peak latencies of wave V. Results indicated a transient impairment of the auditory brainstem function during the headache in pediatric migraine patients (Firat Y. et al, 2006).…”

mentioning

confidence: 84%

Auditory Brainstem Evoked Responses In Migraine Patients

2009

IJN

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Introduction: Migraine is a painful neurological condition and the pathogenesis of migraine is not completely understood. Some researchers are of opinion that cortex may be involved whereas others hold the brainstem responsible. Aim: The aim of the present study was to evaluate the brainstem auditory evoked potentials in patients with migraine. Methodology:25 patients in the age range of 10-45 years, diagnosed as having migraine (with or without aura) were taken as the study group. Out of these 25 subjects, 6 (4 males, 2 females) subjects reported headache during the testing period. Control group consisted of 25 healthy subjects in the age range of 10 to 45 years with no complaint of migraine. Brainstem auditory evoked potentials were recorded using insert ear phones. Results: There was a significant difference between absolute latencies of study group and control group. Similarly, significant results were obtained for interpeak latencies between control and study group. It was observed that prolongation in interpeak latency was reported in those subjects who had an acute attack of migraine during ABR testing. Conclusion: It is concluded that there is an involvement of brainstem structures during migraine attack and this is supported by the prolongation of interpeak latencies of waves in ABER. Therefore, Auditory brainstem evoked responses can be used as an effective tool in making the neurophysiological evaluation of the auditory pathway which further plays an important role in the explanation of pathophysiology of migraine.

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“…Some authors reported prolonged wave V latency and I-V interwave peak latencies (IPL) during the headache attack [Firat et al, 2006], whereas others reported some abnormalities in the form of prolonged absolute latency or prolonged IPL or both in migraine [Dash et al, 2008]. Bayazit et al [2001] found that 35% of the studied migraine cases had abnormal ABR, with elongation in the absolute wave latencies or elongation in both wave latencies and IPL.…”

Section: Discussionmentioning

confidence: 99%

Audiological Findings in Patients with Vestibular Migraine and Migraine: History of Migraine May Be a Cause of Low-Tone Sudden Sensorineural Hearing Loss

Xue

Lin

et al. 2020

Audiol Neurotol

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Introduction: The aim of this study was to investigate and compare the auditory findings in migraine, vestibular migraine (VM), and healthy controls. Methods: Twenty-eight migraine patients (56 ears), 18 VM (36 ears), and 25 healthy controls (50 ears) were included. Audiometry, speech discrimination scores, distortion product optoacoustic emission (DPOAE), and auditory brainstem response were tested. Results: The pure tone in the VM group showed higher thresholds at lower frequencies (250, 500, 1,000, 2,000 Hz) than the control group, with statistical differences observed (P_{250 Hz} = 0.001, P_{500 Hz} = 0.003, P_{1,000 Hz} = 0.016, P_{2,000 Hz} = 0.002). Compared with the healthy controls, the patients with VM had significantly lower amplitudes of DPOAE at 1 kHz (p < 0.001) and 2 kHz (p = 0.020), and the patients with migraine had lower amplitudes at 2 kHz (p = 0.042). Compared with the control group, the patients with migraine reported prolonged latency of wave V (p = 0.016) and IPL I–V (p = 0.003). The patients with VM had significant prolongation of IPL I–V (p = 0.024). Conclusion: Not only the peripheral, but also the central auditory system was involved in patients with migraine and VM. In particular, lower frequencies of the auditory system were more likely to be involved in VM. The history of migraine may be a cause of low-tone sudden sensorineural hearing loss.

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Auditory brainstem response in pediatric migraine: During the attack and asymptomatic period

Cited by 15 publications

References 29 publications

Altered brainstem auditory evoked potentials in a rat central sensitization model are similar to those in migraine

Altered brainstem auditory evoked potentials in a rat central sensitization model are similar to those in migraine

Auditory Brainstem Evoked Responses In Migraine Patients

Audiological Findings in Patients with Vestibular Migraine and Migraine: History of Migraine May Be a Cause of Low-Tone Sudden Sensorineural Hearing Loss

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