Auditory Brainstem Responses (ABR) of Rats during Experimentally Induced Tinnitus: Literature Review

Domarecka, Ewa; Szczepek, Agnieszka J.

doi:10.3390/brainsci10120901

Cited by 15 publications

(15 citation statements)

References 111 publications

(711 reference statements)

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“…There is no consensus yet on potential AEP changes at the level of the brainstem and the midbrain. Evidence from animal studies with salicylate-induced tinnitus revealed shorter ABR peak latencies, reduced wave I amplitudes, and increased amplitude of wave IV ( 45 ). In contrast, in animals with noise-induced tinnitus, all ABR waves had reduced amplitudes ( 45 ).…”

Section: Introductionmentioning

confidence: 99%

Brainstem evoked auditory potentials in tinnitus: A best-evidence synthesis and meta-analysis

et al. 2022

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IntroductionAccumulating evidence suggests a role of the brainstem in tinnitus generation and modulation. Several studies in chronic tinnitus patients have reported latency and amplitude changes of the different peaks of the auditory brainstem response, possibly reflecting neural changes or altered activity. The aim of the systematic review was to assess if alterations within the brainstem of chronic tinnitus patients are reflected in short- and middle-latency auditory evoked potentials (AEPs).MethodsA systematic review was performed and reported according to the PRISMA guidelines. Studies evaluating short- and middle-latency AEPs in tinnitus patients and controls were included. Two independent reviewers conducted the study selection, data extraction, and risk of bias assessment. Meta-analysis was performed using a multivariate meta-analytic model.ResultsTwenty-seven cross-sectional studies were included. Multivariate meta-analysis revealed that in tinnitus patients with normal hearing, significantly longer latencies of auditory brainstem response (ABR) waves I (SMD = 0.66 ms, p < 0.001), III (SMD = 0.43 ms, p < 0.001), and V (SMD = 0.47 ms, p < 0.01) are present. The results regarding possible changes in middle-latency responses (MLRs) and frequency-following responses (FFRs) were inconclusive.DiscussionThe discovered changes in short-latency AEPs reflect alterations at brainstem level in tinnitus patients. More specifically, the prolonged ABR latencies could possibly be explained by high frequency sensorineural hearing loss, or other modulating factors such as cochlear synaptopathy or somatosensory tinnitus generators. The question whether middle-latency AEP changes, representing subcortical level of the auditory pathway, are present in tinnitus still remains unanswered. Future studies should identify and correctly deal with confounding factors, such as age, gender and the presence of somatosensory tinnitus components.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021243687, PROSPERO [CRD42021243687].

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Section: Introductionmentioning

confidence: 99%

Brainstem evoked auditory potentials in tinnitus: A best-evidence synthesis and meta-analysis

et al. 2022

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“…The survey contained questions concerning three main domains with 13 sub-domains, some of which were earlier identified as significant for rat hearing abilities [ 15 ], whereas others were added based on our practical experience. The main domains included animal-related factors, equipment-related factors, and experimental design-dependent factors.…”

Section: Methodsmentioning

confidence: 99%

“…Recently, we performed an analysis of research characterizing changes in ABR profile in various rat models of tinnitus [ 15 ]. We have found a high level of outcome heterogeneity in these studies and have determined that the methodological approach was the primary source of these variations.…”

Section: Introductionmentioning

confidence: 99%

Reporting Data on Auditory Brainstem Responses (ABR) in Rats: Recommendations Based on Review of Experimental Protocols and Literature

et al. 2021

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Research in hearing science is accelerating, and a wealth of data concerning auditory brainstem responses (ABR) in various animal models is published in peer-reviewed journals every year. Recently, we reviewed studies using ABR measurements in tinnitus rat models. We found significant discrepancies in the outcomes of these studies, some due to different research approaches and others due to different methodologies. Thus, the present work aimed to collect comprehensive information on all factors influencing ABR recordings in rats and compile recommendations on ABR data reporting. A questionnaire with queries about animal husbandry, transfer, handling, and the exact test conditions before, during, and after ABR recordings was sent to 125 researchers who published the relevant studies between 2015 and 2021. Eighteen researchers provided detailed answers on factors related to ABR measurements. Based on the analysis of the returned questionnaires, we identified three domains reflecting animal-, equipment-, and experiment-dependent factors that might influence the ABR outcome, thus requiring reporting in published research. The analysis of survey results led to the compilation of recommendations for reporting ABR outcomes supported by a literature review. Following these recommendations should facilitate comparative and meta-analyses of ABR results provided by various research groups.

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“…Evidence from animal studies with salicylate-induced tinnitus revealed shorter ABR peak latencies, reduced wave I amplitudes, and increased amplitude of wave IV (37). In contrast, in animals with noise-induced tinnitus, all ABR waves had reduced amplitudes (37). This implicates that salicylate and noise induce different changes within the auditory brainstem, but still cause the tinnitus percept.…”

Section: Introductionmentioning

confidence: 94%

“…There is no consensus yet on potential AEP changes at the level of the brainstem and the midbrain. Evidence from animal studies with salicylate-induced tinnitus revealed shorter ABR peak latencies, reduced wave I amplitudes, and increased amplitude of wave IV (37). In contrast, in animals with noise-induced tinnitus, all ABR waves had reduced amplitudes (37).…”

Section: Introductionmentioning

confidence: 95%

Brainstem evoked auditory potentials in tinnitus: a best-evidence synthesis and meta-analysis

Jacxsens

Pauw

Cardon

et al. 2022

Preprint

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Introduction Accumulating evidence suggests a role of the brainstem in tinnitus generation and modulation. Several studies in chronic tinnitus patients have reported latency and amplitude changes of the different peaks of the auditory brainstem response, possibly reflecting neural changes or altered activity. The aim of the systematic review was to assess if alterations within the brainstem of chronic tinnitus patients are reflected in short- and middle-latency auditory evoked potentials (AEPs). Methods A systematic review was performed and reported according to the PRISMA guidelines. Studies evaluating short- and middle-latency AEPs in tinnitus patients and controls were included. Two independent reviewers conducted the study selection, data extraction, and risk of bias assessment. Meta-analysis was performed using a multivariate meta-analytic model. Results Twenty-seven cross-sectional studies were included. Multivariate meta-analysis revealed that in tinnitus patients with normal hearing, significantly longer latencies of auditory brainstem response (ABR) waves I (SMD = 0.66 ms, p < 0.001), III (SMD = 0.43 ms p < 0.001), and V (SMD = 0.47 ms, p < 0.01) are present. The results regarding possible changes in middle-latency responses (MLRs) and frequency-following responses (FFRs) were inconclusive. Discussion The discovered changes in short-latency AEPs reflect alterations at brainstem level in tinnitus patients. More specifically, the prolonged ABR latencies could possibly be explained by high frequency sensorineural hearing loss, or other modulating factors such as cochlear synaptopathy or somatosensory tinnitus generators. The question whether middle-latency AEP changes, representing subcortical level of the auditory pathway, are present in tinnitus still remains unanswered. Future studies should identify and correctly deal with confounding factors, such as age, gender and the presence of somatosensory tinnitus components.

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Auditory Brainstem Responses (ABR) of Rats during Experimentally Induced Tinnitus: Literature Review

Cited by 15 publications

References 111 publications

Brainstem evoked auditory potentials in tinnitus: A best-evidence synthesis and meta-analysis

Brainstem evoked auditory potentials in tinnitus: A best-evidence synthesis and meta-analysis

Reporting Data on Auditory Brainstem Responses (ABR) in Rats: Recommendations Based on Review of Experimental Protocols and Literature

Brainstem evoked auditory potentials in tinnitus: a best-evidence synthesis and meta-analysis

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