Auditory Event-related Potentials in Mild Cognitive Impairment and Alzheimer’s Disease

Morrison, Cassandra; Rabipour, Sheida; Knoefel, Frank; Sheppard, Christine; Taler, Vanessa

doi:10.2174/1567205015666180123123209

Cited by 53 publications

(42 citation statements)

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“…1 and 2). This is consistent with previous reports that AD patients had changes in amplitude of auditory evoked potentials in humans (Buchwald et al, 1989; Irimajiri et al, 2005; Swords et al, 2018); changes of cognitive N200 and P300 waves in AECP in AD patients (i.e., N2 and P3 peaks in mice) were reduced, distinguished from the effect of normal aging (Morrison et al, 2018). Thus, AECP recording could serve as a valuable clinical tool for AD diagnosis.…”

Section: Discussionsupporting

confidence: 93%

Early functional and cognitive declines measured by auditory evoked cortical potentials in Alzheimer’s disease mice

Mei

Liu

Chen

et al. 2021

Preprint

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Alzheimer's disease (AD) is characterized with a progressive loss of memory and cognitive decline. Early detection of AD is critical for prevention and intervention of this common neurodegenerative disease. Previous studies demonstrated that auditory dysfunction could occur at the early stage of AD. Auditory evoked cortical potential (AECP) is an event-related potential reflecting not only neural activation in the auditory cortex but also cognitive activity in the brain. In this study, we recorded AECP in AD mice. AECP in mice usually possessed 3 waveforms. The early sensory P1 and P2 peaks were clearly visible in 1 month old mice. However, the later cognitive P3 peak was not well-developed until the age of 3 months old. In APP/PS1 AD mice, P1 and P2 were reduced at young ages (<6 months old), prior to occurrence of AD phenotypes. Different from normal aging, the cognitive peak of P3 in AD mice was diminished invisible after 4 months old. The latencies of peak N1, P2, and N2 in AD mice before 3 months were shorter than those in WT mice. Consistent with AECP changes, expression of amyloid precursor protein (APP) was visible in the AD mouse auditory cortex at 2 months old. These data indicate that AECP has significant changes in young AD mice and can serve as an early, non-invasive, objective biomarker in AD and AD-related dementia detection and diagnosis.

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Section: Discussionsupporting

confidence: 93%

Early functional and cognitive declines measured by auditory evoked cortical potentials in Alzheimer’s disease mice

Mei

Liu

Chen

et al. 2021

Preprint

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“…These physiological alterations were accompanied by lower accuracy in target detection and longer RT. Other studies testing an auditory (Hedges et al, 2016;Lai et al, 2010; reviewed by Morrison et al, 2018) or visual (Parra et al, 2012) OB paradigm confirmed the results of the decreased amplitude and the longer latency of the P3 component in AD patients.…”

Section: Role Of the Locus Coeruleus-norepinephrine System In P3 Genesupporting

confidence: 59%

P1‐223: Functional Markers for Cerebral Norepinephrine Deficiency in Alzheimer’s Disease

Kiven

Loetgering

Kleineidam

et al. 2016

Alzheimer's & Dementia

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Background: In primary care units Frailty Ambulatory is dedicated to elderly people and is an example of health innovation. In the light of a complex rethinking of primary care, it is aimed to promote initiative medicine in the field of degenerative and chronic diseases. In short, Frailty Ambulatories have to make easier the "art" of caring elderly patients' complex needs through geriatricians and outof-hospital network services. The aim of the present study was to analyze data from 300 consecutive patients sent to our ambulatories. Methods:The starting point is caring patients and their needs. The first step is represented by over-65 year-old patients' selection according to the criteria of prefrailty and frailty (at least one Fried's criterion and the patient sent to geriatrician by general practitioner). Results:Of 300 patients, 118 (39,3%) were men, mean age 82,79 6 6,65 years old, BMI 22,176 2,15 kg/m 2 . After performing multidimensional assessment we found the following scores: MMSE 11,0562,44; ADL 0,9562,06; IADL 0,0460,188; CIRS 4,9561,72. The number of drugs used was 6,16 6 2,20. The most frequent Fried's criterion found was fatigue (97,3%, Table 1); criteria's mean/patient was 4,74 6 0,56. In 80,3% out of the patients all the five criteria were found, in 13.3% four criteria, in 6,4% three criteria (Figure 1). After bivariate relationship Fried's criteria were found to be significantly correlated to MMSE and heart failure. After multivariate analysis the relationship was kept with MMSE (beta -0,209; p¼0,0001). Conclusions: Experimental activity in Frailty Ambulatories could offer a tool able to recognize conditions of prefrailty/frailty. This can lead to a consistent and complete care response, preventing/decreasing disability conditions. Data analyses timely carried on by provincial health authority let plan the possible continuation of experimentation.Background:The locus coeruleus (LC) as the only source for norepinephrine (NE) in the human brain shows early degeneration in Alzheimer's disease (AD). The LC-NE system is involved in attentional processes and different behavioral and functional markers (e.g. evoked EEG potentials, BOLD responses, pupillary dilatation) have been identified as potential markers for LC-NEfunctionality. Here, we assessed whether these markers are characteristically altered in AD, thus providing potential surrogate markers for interventional trials targeting the LC-NE-system. Methods: We aim at including patients (planned: n¼30) with cerebrospinal fluid-biomarker evidence for AD and age-matched healthy controls (planned: n¼30). We obtain reaction times and accuracy, event-related electroencephalography (EEG) potentials (P300b), task-related pupil dilation and event-related blood oxygen level dependent (BOLD) responses in a stimulus detection task (Oddball-paradigm). Additionally, structural magnetic resonance imaging (MRI) with neuromelanine-sensitive sequences is applied to determine a volumetric measure for the LC. Here, we present preliminary results for 15 subjects with ...

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“…Thus, the neural systems supporting episodic memory may be key candidate sites in which the first signs of AD-related neuropathology arise during the ‘silent’ phase of the disease [ 18, 19 ]. Consistent with this theory, differences in task-related brain activity in people with mild cognitive impairment and AD, compared to healthy older adults, appear to reflect declines in memory and attention processing [ 20, 21 ], and may index changes related to AD progression [ 22, 23 ]. Moreover, brain activity related to memory encoding in regions that subserve episodic memory, including hippocampal, parahippocampal, posterior parietal, and lateral prefrontal cortex, appears different in healthy aging, mild cognitive impairment, and AD [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

APOE4 Status is Related to Differences in Memory-Related Brain Function in Asymptomatic Older Adults with Family History of Alzheimer’s Disease: Baseline Analysis of the PREVENT-AD Task Functional MRI Dataset

Rabipour

Rajagopal

et al. 2020

JAD

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Background: Episodic memory decline is one of the earliest symptoms of late-onset Alzheimer's disease (AD). Older adults with the apolipoprotein E 4 (+APOE4) genetic risk factor for AD may exhibit altered patterns of memory-related brain activity years prior to initial symptom onset. Objective: Here we report the baseline episodic memory task functional MRI results from the PRe-symptomatic EValuation of Experimental or Novel Treatments for Alzheimer's Disease cohort in Montreal, Canada, in which 327 healthy older adults were scanned within 15 years of their parent's conversion to AD.

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Auditory Event-related Potentials in Mild Cognitive Impairment and Alzheimer’s Disease

Abstract: ERPs may be sensitive to progressive cognitive changes due to MCI and AD. The P300 and N200 may help identify patients who are likely to progress from MCI to AD, and could be a valuable clinical tool.

Cited by 53 publications

References 0 publications

Early functional and cognitive declines measured by auditory evoked cortical potentials in Alzheimer’s disease mice

Early functional and cognitive declines measured by auditory evoked cortical potentials in Alzheimer’s disease mice

P1‐223: Functional Markers for Cerebral Norepinephrine Deficiency in Alzheimer’s Disease

APOE4 Status is Related to Differences in Memory-Related Brain Function in Asymptomatic Older Adults with Family History of Alzheimer’s Disease: Baseline Analysis of the PREVENT-AD Task Functional MRI Dataset

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