Auditory physiological properties of the neurones in the inferior colliculus of the big brown bat,Eptesicus fuscus

Jen, Philip H.‐S.; Schlegel, P.

doi:10.1007/bf00609669

Cited by 92 publications

(37 citation statements)

References 17 publications

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“…High BF neurons tended to have high MTs and short response latencies. These findings are similar to those obtained from previous studies on the same species of bat (Casseday and Covey 1992;Jen and Schlegel 1982;Jen et al 1987;Pinheiro et al 1991;Poon et al 1990;Wu and Jen 1991).…”

Section: Resultssupporting

confidence: 92%

“…The discharge patterns of all 110 neurons studied can be described as phasic responders (P; n = 74, 67%), phasic bursters (PB; n = 19, 17%) or tonic responders (T; n = 17, 16%) as in previous studies (Jen and Schlegel 1982;Pollak et al 1978). When stimulated with 3-and 19-ms pulses, phasic responders always discharged 1-2 impulses (Fig.…”

Section: Bicuculline Application On Neuronal Responsessupporting

confidence: 58%

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GABAergic disinhibition changes the recovery cycle of bat inferior collicular neurons

Jen

Zheng

1997

Journal of Comparative Physiology A: Sensory, Neural, and Behav

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This study examines the contribution of GABAergic inhibition to the discharge pattern and recovery properties of 110 bat inferior collicular neurons by means of bicuculline application to their recording sites. When stimulated with single pulses, 74 (67%) neurons discharged one or two impulses (phasic responders), 19 (17%) discharged three to ten impulses (phasic bursters) and 17 (16%) discharged impulses throughout the entire stimulus duration (tonic responders). Bicuculline application changed phasic responders into phasic bursters or tonic responders, increased the number of impulses by 10-2000% and shortened the response latency of most neurons. When stimulated with pairs of sound pulses, the recovery cycles of these neurons can be described as: (1) long inhibition (n = 49, 45%); (2) short inhibition (n = 41, 37%); and (3) fast recovery (n = 20, 18%) based upon the 50% recovery time that was either longer than 20 ms, between 10 and 20 ms or shorter than 10 ms. Bicuculline application shortened the 50% recovery time of most neurons by 11-2350% allowing them to respond to pairs of sound pulses at very short interpulse intervals. These data demonstrate that GABAergic inhibition contributes significantly to auditory temporal processing.

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Section: Resultssupporting

confidence: 92%

Section: Bicuculline Application On Neuronal Responsessupporting

confidence: 58%

GABAergic disinhibition changes the recovery cycle of bat inferior collicular neurons

Jen

Zheng

1997

Journal of Comparative Physiology A: Sensory, Neural, and Behav

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“…Neurons tuned for the duration of a stimulus have been found in the central auditory systems of a number of vertebrates, including frogs (Potter, 1965;Narins and Capranica, 1980;Hall and Feng, 1986;Gooler and Feng, 1992), mice (Brand et al, 2000), chinchillas (Chen, 1998), cats , and various species of echolocating bats (Jen and Schlegel, 1982;Pinheiro et al, 1991;Casseday et al, 1994;Condon et al, 1996;Galazyuk and Feng, 1997;Fuzessery and Hall, 1999). Neurons tuned to the duration of a stationary bar of light have also been found in areas 17 and 18 of the cat visual cortex (Duysens et al, 1996).…”

Section: Discussionmentioning

confidence: 99%

Temporal Masking Reveals Properties of Sound-Evoked Inhibition in Duration-Tuned Neurons of the Inferior Colliculus

et al. 2003

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The inferior colliculus (IC) is the first place in the central auditory pathway where duration-selective neurons are found. Previous neuropharmacological and electrophysiological studies have shown that they are created there and have led to a conceptual model in which excitatory and inhibitory inputs are offset in time so that the cell fires only when sound duration is such that onset-and offsetevoked excitation coincide; the response is suppressed by inhibition at other durations. We tested predictions from the model using paired tone stimulation and extracellular recording in the IC of the big brown bat, Eptesicus fuscus. Responses to a best duration (BD) tone were used as a probe to examine the strength and time course of inhibition activated by a nonexcitatory (NE) tone of the same frequency but differing in duration. As the relative time between the BD and NE tones was varied, the activity evoked by the BD tone was affected in ways comparable with backward, simultaneous, and forward masking. Responses to the BD tone were completely suppressed at short interstimulus intervals when the BD tone preceded the NE tone. Suppression was also seen when the stimuli temporally overlapped and summed and at intervals when the BD tone followed the NE tone. The results show that duration-selective neurons receive an onsetevoked, inhibitory input that precedes their excitatory input. The period of leading inhibition was correlated with BD and first spike latency. The results suggest how inhibition in the CNS could explain temporal masking phenomena, including backward masking.

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“…Higher order temporal features, such as gap and signal duration, are analyzed by upstream auditory nuclei. In particular, cells tuned to stimulus duration, known as duration-tuned neurons (DTNs), are found first in the auditory midbrain of amphibians (Narins and Capranica, 1980) and mammals (Jen and Schlegel, 1982;Casseday et al, 1994;Chen, 1998;Fuzessery and Hall, 1999;Brand et al, 2000;Pérez-González et al, 2006;Wang et al, 2006). Auditory DTNs exist across vertebrate species and taxa and vary widely in their preferred range of signal durations (for review, see Sayegh et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Duration Tuning across Vertebrates

Aubie

Sayegh²,

Faure³

2012

J. Neurosci.

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Signal duration is important for identifying sound sources and determining signal meaning. Duration-tuned neurons (DTNs) respond preferentially to a range of stimulus durations and maximally to a best duration (BD). Duration-tuned neurons are found in the auditory midbrain of many vertebrates, although studied most extensively in bats. Studies of DTNs across vertebrates have identified cells with BDs and temporal response bandwidths that mirror the range of species-specific vocalizations. Neural tuning to stimulus duration appears to be universal among hearing vertebrates. Herein, we test the hypothesis that neural mechanisms underlying duration selectivity may be similar across vertebrates. We instantiated theoretical mechanisms of duration tuning in computational models to systematically explore the roles of excitatory and inhibitory receptor strengths, input latencies, and membrane time constant on duration tuning response profiles. We demonstrate that models of duration tuning with similar neural circuitry can be tuned with species-specific parameters to reproduce the responses of in vivo DTNs from the auditory midbrain. To relate and validate model output to in vivo responses, we collected electrophysiological data from the inferior colliculus of the awake big brown bat, Eptesicus fuscus, and present similar in vivo data from the published literature on DTNs in rats, mice, and frogs. Our results support the hypothesis that neural mechanisms of duration tuning may be shared across vertebrates despite species-specific differences in duration selectivity. Finally, we discuss how the underlying mechanisms of duration selectivity relate to other auditory feature detectors arising from the interaction of neural excitation and inhibition.

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Auditory physiological properties of the neurones in the inferior colliculus of the big brown bat,Eptesicus fuscus

Cited by 92 publications

References 17 publications

GABAergic disinhibition changes the recovery cycle of bat inferior collicular neurons

GABAergic disinhibition changes the recovery cycle of bat inferior collicular neurons

Temporal Masking Reveals Properties of Sound-Evoked Inhibition in Duration-Tuned Neurons of the Inferior Colliculus

Duration Tuning across Vertebrates

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