Auditory research involving antioxidants

Darrat, Ilaaf; Ahmad, Nadir; Seidman, Kevin; Seidman, Michael D.

doi:10.1097/moo.0b013e3282efa641

Cited by 61 publications

(46 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…4 Recently, there is a trend in literature exploring the role of oxidative stress and genetic aspects of oxidative stress in noise induced hearing loss. 5,6 Reactive oxygen species (ROS) including the members superoxide (O2 .-), hydroxyl radical ( . OH), hydrogen peroxide (H2O2), singlet oxygen ( 1 O2), and nitric oxide (NO . )…”

Section: Introductionmentioning

confidence: 99%

The Effects of Noise on Oxidative and Antioxidative Balance in Human Erythrocytes

Pınar¹,

Atlı²,

Alaçam³

et al. 2011

UHOD

View full text Add to dashboard Cite

Reactive oxygen and nitrogen species have been implicated in the pathogenesis of noise-induced hearing loss. In this case-control study, we investigated the oxidative and antioxidative status of erythrocytes from workers in noisy workplace. Blood samples of 127 workers in noisy workplace (WNW) and 117 workers in non-noisy workplace (WNNW) from the same company were taken into tubes with potassium EDTA as anticoagulant in order to obtain hemolysate. Total superoxide dismutase (SOD) and catalase (CAT) activities as the enzymes of antioxidative defense mechanism in the erythrocytes together with malondialdehyde (MDA) as the lipid peroxidation index and total nitric oxide (NO) as an index for nitrogen species analyses were performed by spectrophotometric methods. SOD activity was found to be 450.0±106.4 U/g Hb in WNW and 443.1±83.1 U/g Hb in WNNW. The difference between two groups were not statistically significant (p= 0.582). CAT activity was found to be 426.0±98.0 k/g Hb in WNW and 432.6±109.0 k/g Hb in WNNW showing statistically insignificant difference (p= 0.621). MDA levels in erythrocytes from WNW was significantly higher than WNNW (39.28±10.22 nmol/g Hb and 32.51±10.73 nmol/g Hb, respectively and p= 0.0001). On the other hand, NO levels were found to be significantly reduced in WNW (0.275±0.187 µmol/g Hb) compared to WNNW (0.382±0.284 µmol/g Hb) (p= 0.001). When we analyzed the hematological parameters, all the cell counts increased in WNW except monocytes and platelets compared to WNNW (p= 0.0001). Related to this changes, hemoglobin, MCHC, and hematocrit also increased in WNW (p= 0.0001). The oxidative stress, which is possibly propagated by the physical environment, seems to have an important pathophysiological role in hearing loss and lipid peroxidative cellular changes in all of the workers who work in noisy occupations.Key words: Noise, Worker, Oxidative stress, Superoxide dismutase, Catalase, Malondialdehyde, Nitric oxide ÖZET Gürültünün ‹nsan Eritrositlerindeki Oksidan ve Antioksidan Dengeye EtkileriReaktif oksijen ve nitrojen türleri, yüksek ses kaynakl› duyma kay›plar›nda önemli bir patolojik faktör olarak kabul görmekte-dir. Bu vaka kontrollü çal›flmam›zda yüksek sesli ortamlarda çal›flan iflçilerin eritrositlerinde oksidan ve antioksidan dengeyi araflt›rd›k. Yüksek sesli ortamda çal›flan (YSOÇ) 127 iflçi ile normal ortamda çal›flan (NOÇ) 117 iflçinin kanlar› hemolizat elde etmek üzere içinde antikoagulan olarak potasyum EDTA bulunan tüplere al›nd›.

show abstract

Section: Introductionmentioning

confidence: 99%

The Effects of Noise on Oxidative and Antioxidative Balance in Human Erythrocytes

Pınar¹,

Atlı²,

Alaçam³

et al. 2011

UHOD

View full text Add to dashboard Cite

show abstract

“…Further, they are known to act as physiological signals or intermediaries in cellular processes that are homeostatic. The term "oxidative stress" has been used by many authorities to denote a state where the generation of ROS exceeds the needs of the cell or when the cell's ability to neutralize their reactiveness has been compromised (Halliwell 2006(Halliwell , 2009Darrat et al 2007 ).…”

Section: Overview Of Human Pathology and Rosmentioning

confidence: 99%

Antioxidants and Their Effect on Stress-Induced Pathology in the Inner Ear

Shirwany¹,

Seidman

2015

Free Radicals in ENT Pathology

View full text Add to dashboard Cite

“…There are several intrinsic free radical scavengers, such as glutathione. When oxidative stress overwhelms the activity of endogenous free radical scavengers and antioxidants, ROS accumulates and causes damage and eventually the programmed cell death of affected auditory hair cells [10]. Administration of exogenous antioxidants such as sodium thiosulfate (STS), D -methionine, and N-acetylcysteine (NAC) can reduce the oxidative stress burden in cochlear tissues which will protect the cochlea against hearing loss (fig.…”

Section: Antioxidantsmentioning

confidence: 99%

“…glutathione) that are the natural cellular defense against oxidative stress within a cell [10]. A small number of the drugs that are currently being studied for the treatment and prevention of acute hearing loss target these pro-death signaling pathways, and even fewer of these otoprotective drugs are also capable of activating pro-survival pathways, such as the nuclear factor ĸB (NFĸB) signaling pathway in auditory hair cells.…”

Section: Introductionmentioning

confidence: 99%

Blocking Pro-Cell-Death Signal Pathways to Conserve Hearing

Dinh

Water²

2009

Audiol Neurotol

View full text Add to dashboard Cite

The programmed cell death of stress-damaged auditory hair cells can occur through a variety of signal pathways, and therapeutic modalities that block pro-cell-death pathways are being developed and evaluated for hearing preservation. Because of their ability to have both anti-inflammatory and anti-apoptotic actions, corticosteroids have long been used to protect against several types of acute sensorineural hearing loss. Other anti-apoptotic drugs that target the mitogen-activated protein kinase (MAPK)/c-Jun-N terminal kinase (JNK) signal cascade, such as D-JNKI-1 (AM-111) and SP600125, have produced promising results both in vitro and in laboratory animal studies, with AM-111 showing promise in preliminary clinical trials. Antioxidant drugs, e.g. sodium thiosulfate, N-acetylcysteine, and D-methionine, have been shown in animal studies to attenuate permanent threshold shifts in hearing by reducing oxidative stress. In addition to reviewing selected therapeutic trends for the conservation of hearing, we review our experiences with dexamethasone and D-JNKI-1 and report results from our current research.

show abstract

Auditory research involving antioxidants

Abstract: This review elucidates the role of antioxidants in hearing loss and illustrates the continued evolution of research efforts in this field.

Cited by 61 publications

References 36 publications

The Effects of Noise on Oxidative and Antioxidative Balance in Human Erythrocytes

The Effects of Noise on Oxidative and Antioxidative Balance in Human Erythrocytes

Antioxidants and Their Effect on Stress-Induced Pathology in the Inner Ear

Blocking Pro-Cell-Death Signal Pathways to Conserve Hearing

Contact Info

Product

Resources

About