2023
DOI: 10.1016/j.scog.2023.100290
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Augmentation therapy with serotonin1A receptor partial agonists on neurocognitive function in schizophrenia: A systematic review and meta-analysis

Risa Yamada,
Ayumu Wada,
Andrew Stickley
et al.
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“…Other animal experiments have shown that 5-HT1A receptor agonists can improve brain energy metabolism in neonatal rats with NMDA receptor blockade [ 54 ] and promote hippocampal neurogenesis in rats [ 37 ]. However, a recent meta-analysis on the therapeutic effects of serotonin 1A receptor partial agonists as augmentation therapy for neurocognitive function in patients with schizophrenia revealed no cognitive benefits in verbal learning, working memory, and executive function [ 55 ]. This finding is consistent with the results presented in this article.…”
Section: Discussionmentioning
confidence: 99%
“…Other animal experiments have shown that 5-HT1A receptor agonists can improve brain energy metabolism in neonatal rats with NMDA receptor blockade [ 54 ] and promote hippocampal neurogenesis in rats [ 37 ]. However, a recent meta-analysis on the therapeutic effects of serotonin 1A receptor partial agonists as augmentation therapy for neurocognitive function in patients with schizophrenia revealed no cognitive benefits in verbal learning, working memory, and executive function [ 55 ]. This finding is consistent with the results presented in this article.…”
Section: Discussionmentioning
confidence: 99%