Augmented antiviral T cell immunity by oral administration of
            <scp>IMM‐124E</scp>
            in preclinical models and a phase I/
            <scp>IIa</scp>
            clinical trial: A method for the prevention and treatment of
            <scp>COVID</scp>
            ‐19

Ishay, Yuval; Potruch, Assaf; Weksler-Zangen, Sarah; Shabat, Yehudit; Ilan, Yaron

doi:10.1002/ddr.21890

Cited by 6 publications

(6 citation statements)

References 32 publications

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“…These effects were attributed to the potential immunomodulatory effect of GSLs [ 19 , 37 ]. They also support a potential oral-immunotherapy-based mechanism of action recently described for several compounds [ 21 , 25 , 29 , 37 - 48 ].…”

Section: Discussionsupporting

confidence: 83%

Increased hepatic Akt phosphorylation alleviated glucose intolerance and improved liver function in leptin-deficient mice

Adar¹,

Mizrahi²,

Lichtenstein³

et al. 2023

ceh

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Aim of the study: Akt is involved in upregulating the insulin-signaling pathways essential for maintaining glucose metabolism. Glycosphingolipids are involved in the pathogenesis of glucose intolerance and associated target organ injury. On the other hand, oral administration of β-glucosylceramide (GC) has been shown to alleviate insulin resistance. The present study aimed to determine the effects of oral administration of insulin and GC, separately and in combination, on Akt expression and the subsequent effect on metabolic syndrome characteristics in leptin-deficient mice. Material and methods: Four groups of leptin-deficient ob/ob mice were orally administered for four weeks: vehicle, GC, short-acting insulin, and GC combined with insulin. Mice were followed for hepatic Akt expression and changes in tumor necrosis factor α (TNF-α) level, hyperlipidemia, and liver damage. Results: In mice that received insulin or GC, particularly those that received both, the liver phosphorylation of Akt was significantly increased compared to those that received only vehicle. Serum TNF-α levels decreased in insulin-treated mice. These effects were associated with alleviating glucose intolerance and hyperlipidemia, as manifested by a significant glucose tolerance test improvement and reductions in serum triglyceride and cholesterol levels. Significant liver damage alleviation was noted by liver enzyme reductions in all treated groups, along with liver steatosis in the insulin-treated mice. Conclusions: These data established the potential use of oral insulin administration with glycosphingolipids to alleviate glucose intolerance and associated liver damage and hyperlipidemia via increased Akt expression in the liver. The data support targeting Akt as a potent therapeutic target for metabolic syndrome.

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Section: Discussionsupporting

confidence: 83%

Increased hepatic Akt phosphorylation alleviated glucose intolerance and improved liver function in leptin-deficient mice

Adar¹,

Mizrahi²,

Lichtenstein³

et al. 2023

ceh

Self Cite

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“…The human gut is a complex organ involved in multiple physiological processes. The gut immune system and microbiota play essential roles in health and disease, 51,154,[161][162][163][164][165][166][167] and their roles in sepsis have been established. BT and several other microbiota-linked mechanisms contribute to sepsis and subsequent MOF development.…”

Section: Discussionmentioning

confidence: 99%

“…The system will provide a method for improving the response to the currently used measures targeting BT and dysbiosis to reduce the hyperinflammatory response associated with sepsis, similar to other disorders. [153][154][155][156][157][158][159][160]…”

Section: Therapeutic Advances In Gastroenterologymentioning

confidence: 99%

The role of bacterial translocation in sepsis: a new target for therapy

Potruch

Schwartz

Ilan

2022

Therap Adv Gastroenterol

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Sepsis is a leading cause of death in critically ill patients, primarily due to multiple organ failures. It is associated with a systemic inflammatory response that plays a role in the pathogenesis of the disease. Intestinal barrier dysfunction and bacterial translocation (BT) play pivotal roles in the pathogenesis of sepsis and associated organ failure. In this review, we describe recent advances in understanding the mechanisms by which the gut microbiome and BT contribute to the pathogenesis of sepsis. We also discuss several potential treatment modalities that target the microbiome as therapeutic tools for patients with sepsis.

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“…In this research, orally administered HBC during the 5 five days resulted in augmentation of the number of antiviral T cells responses to antigens in healthy participants. Thus, it was suggested that the application of HBC shows great potential for the prevention of COVID-19 ( 87 ).…”

Section: The Main Immunomodulating and Bioactive Components Of Bovine...mentioning

confidence: 99%

Bovine colostrum and its potential contributions for treatment and prevention of COVID-19

Duman,

Karav

2023

Front. Immunol.

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Bovine colostrum (BC) is the initial milk an animal produces after giving birth, particularly in the first few days. Numerous bioactive substances found in BC, including proteins, enzymes, growth factors, immunoglobulins, etc., are beneficial to human health. BC has a significant role to play as part of a healthy diet, with well-documented health and nutritional advantages for people. Therefore, the use of BC and its crucial derivatives in the development of functional food and pharmaceuticals for the prevention of several diseases such as gastrointestinal and respiratory system disorders is becoming increasingly popular around the world. A novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified as the cause of a cluster of pneumonia cases that is called Coronavirus Disease 2019 (COVID-19) in China. After the first SARS-CoV-2 virus-related fatality was announced, the illness quickly spread throughout China and to other continents, causing a pandemic. Since then, numerous studies have been initiated to develop safe and efficient treatments. To prevent viral infection and potential lingering effects, it is important to investigate alternative treatments for COVID-19. Due to its effective bioactive profile and its immunomodulatory roles in biological processes, BC might be considered a promising approach to assist in combating people affected by the SARS-CoV-2 or prevention from the virus. BC has immunomodulatory effects because to its high concentration of bioactive components such as immunoglobulins, lactoferrin, cytokines, and growth factors, etc., which might help control immunological responses, potentially fostering a balanced immune response. Furthermore, its bioactive components have a potential cross-reactivity against SARS-CoV-2, aiding in virus neutralization and its comprehensive food profile also supplies important vitamins, minerals, and amino acids, fostering a healthy immune system. Hence, the possible contributions of BC to the management of COVID-19 were reviewed in this article based on the most recent research on the subject. Additionally, the key BC components that influence immune system modulation were evaluated. These components may serve as potential mediators or therapeutic advantages in COVID-19.

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Augmented antiviral T cell immunity by oral administration of IMM‐124E in preclinical models and a phase I/ IIa clinical trial: A method for the prevention and treatment of COVID ‐19

Cited by 6 publications

References 32 publications

Increased hepatic Akt phosphorylation alleviated glucose intolerance and improved liver function in leptin-deficient mice

Increased hepatic Akt phosphorylation alleviated glucose intolerance and improved liver function in leptin-deficient mice

The role of bacterial translocation in sepsis: a new target for therapy

Bovine colostrum and its potential contributions for treatment and prevention of COVID-19

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