Augmented EPR effect by photo-triggered tumor vascular treatment improved therapeutic efficacy of liposomal paclitaxel in mice bearing tumors with low permeable vasculature

Araki, Tomoya; Ogawara, Ken Ichi; Suzuki, Haruka; Kawai, Rie; Watanabe, Takeru; Ono, Tsutomu; Higaki, Kazutaka

doi:10.1016/j.jconrel.2014.12.038

Cited by 43 publications

(21 citation statements)

References 39 publications

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“…Araki et al studied the effects of photo‐triggered tumor vascular treatment (PVT) using PpIX‐polymeric nanoparticles (PEG‐block‐polylactic acid) in Colon‐26 (C26; high permeable vasculature) and B16/BL6 (B16; low permeable vasculature) tumor‐bearing mice . PVT enhanced the antitumor activity in these models by inducing apoptotic tumor vascular endothelial cell death and platelet aggregation.…”

Section: Light‐responsive Liposomesmentioning

confidence: 99%

Stimuli‐responsive liposomes for drug delivery

Lee

Thompson

2017

WIREs Nanomed Nanobiotechnol

371

190

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The ultimate goal of drug delivery is to increase the bioavailability and reduce the toxic side effects of the active pharmaceutical ingredient (API) by releasing at a specific site of action. In the case of antitumor therapy, association of the therapeutic agent with a carrier system can minimize damage to healthy, non-target tissues, while limit systemic release and promoting long circulation to enhance uptake at the cancerous site due to the enhanced permeation and retention effect (EPR). Stimuli-responsive systems have become a promising way to deliver and release payloads in a site-selective manner and carrier systems have been derived from a wide variety of materials, including inorganic nanoparticles, lipids, and polymers that have been imbued with stimuli-sensitive properties to accomplish triggered release. The unique features in the tumor microenvironment can serve as an endogenous stimulus (pH, redox potential, or unique enzymatic activity) or the locus of an applied external stimulus (heat or light) to trigger the controlled release of API. Triggered release is generally based on the principle of membrane destabilization from local defects within bilayer membranes to effect release of liposome-entrapped drugs. This review focuses on the literature appearing between November 2008–February 2016 that reports new developments in stimuli-sensitive liposomal drug delivery strategies using pH change, enzyme transformation, redox reactions, and photochemical mechanisms of activation.

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Section: Light‐responsive Liposomesmentioning

confidence: 99%

Stimuli‐responsive liposomes for drug delivery

Lee

Thompson

2017

WIREs Nanomed Nanobiotechnol

371

190

View full text Add to dashboard Cite

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“…PDT generates singlet oxygen, which can damage vascular endothelial cells and induce the formation of endothelial intercellular gaps, resulting in leakier tumor microvasculature and an augmented EPR effect [29,30]. PDT enhances liposomal drug delivery in mouse models of cancer in different scenarios using photosensitizers that: 1) extravasate to the tumor after leaving circulation [31]; 2) remain in blood circulation for vascular PDT [29]; 3) are specifically targeted to tumor neovasculature [32].…”

Section: Introductionmentioning

confidence: 99%

Porphyrin-phospholipid liposomes with tunable leakiness

Luo

Carter

Razi

et al. 2015

Journal of Controlled Release

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Drug bioavailability is a key consideration for drug delivery systems. When loaded with doxorubicin, liposomes containing 5 molar % porphyrin-phospholipid (HPPH liposomes) exhibited in vitro and in vivo serum stability that could be fine-tuned by varying the drug-to-lipid ratio. A higher drug loading ratio destabilized the liposomes, in contrast to standard liposomes which displayed an opposite and less pronounced trend. Following systemic administration of HPPH liposomes, near infrared laser irradiation induced vascular photodynamic damage, resulting in enhanced liposomal doxorubicin accumulation in tumors. In laser-irradiated tumors, the use of leaky HPPH liposomes resulted in improved doxorubicin bioavailability compared to stable standard liposomes. Using this approach, a single photo-treatment with 10 mg/kg doxorubicin rapidly eradicated tumors in athymic nude mice bearing KB or MIA Paca-2 xenografts.

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“…36) Tumor-selective light irradiation with laser light was conducted for 3 min at 15 min after PN-Por injection (0.1 mg/kg as PppIX-DME), and PL-PTX was intravenously administered into B16 tumor-bearing mice just after light irradiation. As a result, more potent anti-tumor effect was observed, which would be attributed to the higher EPR effect-based tumor disposition of PL-PTX due to the vascular permeability enhanced by reduced pericyte-coverage by PVT 36) (Fig. 2).…”

Section: Application Of Photodynamic Treatment To Enhance Tumor Vascumentioning

confidence: 99%

Nanoparticle-Based Photodynamic Therapy: Current Status and Future Application to Improve Outcomes of Cancer Treatment

Ogawara

Higaki

2017

CHEMICAL & PHARMACEUTICAL BULLETIN

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Photodynamic therapy (PDT) is an emerging cancer treatment that uses photosensitizers (PS), along with light to activate them, resulting in oxidation of various biological components in cancer tissues. However, since most potential PS are solubilized and given as aqueous solution, PS is non-specifically distributed in the body, leading to the induction of various side effects in normal tissues that are exposed to daylight such as skin and eyes. To overcome the problem associated with non-specific in vivo disposition of PS, various approaches have been applied to develop safer dosage forms for PS with more efficient tumor delivery and lower disposition to normal tissues. Passive drug targeting to tumors with nanoparticulate formulations has been recognized as one of the potentially useful approaches to improve the poor tissue specificity of conventional cancer chemotherapy and this approach should also be applicable for more efficient tumor delivery of PS. In this review article, several issues concerning the efficacy of PDT using nanoparticle-based formulations are discussed and our recent attempts to temporally enhance the vascular permeability within tumors with photodynamic treatment for the better therapeutic outcome of nanoparticle-based therapy are introduced.

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Augmented EPR effect by photo-triggered tumor vascular treatment improved therapeutic efficacy of liposomal paclitaxel in mice bearing tumors with low permeable vasculature

Cited by 43 publications

References 39 publications

Stimuli‐responsive liposomes for drug delivery

Stimuli‐responsive liposomes for drug delivery

Porphyrin-phospholipid liposomes with tunable leakiness

Nanoparticle-Based Photodynamic Therapy: Current Status and Future Application to Improve Outcomes of Cancer Treatment

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