Augmented immunoexpression of survivin correlates with parameters of aggressiveness in prostate cancer

Danilewicz, Marian; Stasikowska-Kanicka, Olga; Wągrowska-Danilewicz, Małgorzata

doi:10.5114/pjp.2015.51152

Cited by 12 publications

(10 citation statements)

References 23 publications

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“…Kishi et al assessed the levels of mRNA survivin in PCa specimens and reported that survivin expression was associated with adverse pathological features, such as higher pathological T stage, lymph node metastasis, vessel invasion, positive surgical margin and high Gleason score . At the protein level, our results are consistent with previous studies that reported a significant association between survivin overexpression and high Gleason scores .…”

Section: Discussionsupporting

confidence: 91%

Role of survivin expression in predicting biochemical recurrence after radical prostatectomy: a multi‐institutional study

et al. 2016

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ObjectiveTo assess the association of survivin expression with clinicopathological features and biochemical recurrence (BCR) after radical prostatectomy (RP) in a large multi-institutional cohort. MethodsSurvivin expression was evaluated by immunohistochemistry on a tissue microarray of RP cores from 3 117 patients. Survivin expression was considered altered when at least 10% of the tumour cells stained positive. The association of altered survivin expression with BCR was evaluated using Cox proportional hazards regression models. ResultsSurvivin expression was altered in 1 330 patients (42.6%). Altered expression was associated with higher Gleason score on RP (P = 0.001), extracapsular extension (P = 0.019), seminal vesicle invasion (P < 0.001) and lymph node metastases (P = 0.009). The median (interquartile range) follow-up was 38 (21-66) months. Patients with altered survivin expression had a shorter BCR-free survival time than those with normal expression (5-year BCR-free survival estimates: 74.7 vs 79.0%; P = 0.008). Altered survivin expression did not retain its prognostic value, however, after adjustment for the effect of established clinicopathological factors (P = 0.73). Subgroup analyses also showed no independent prognostic value of survivin. ConclusionsSurvivin expression is commonly altered in patients undergoing RP. Altered survivin expression is associated with the clinicopathological features of biologically and clinically aggressive PCa. Survivin expression was associated with BCR only in univariable analysis, limiting its value in daily clinical decision-making.

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Section: Discussionsupporting

confidence: 91%

Role of survivin expression in predicting biochemical recurrence after radical prostatectomy: a multi‐institutional study

et al. 2016

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“…Descriptive and functional data on the presence and role of survivin in prostate cancer published within the last years revealed highly contradictory results [13][14][15][16][17]19,[22][23][24] .…”

Section: Discussionmentioning

confidence: 99%

Subcellular Compartmentalization of Survivin is Associated with Biological Aggressiveness and Prognosis in Prostate Cancer

Hennigs

Minner

Tennstedt

et al. 2020

Sci Rep

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the role of subcellular survivin compartmentalization in the biology and prognosis of prostate cancer is unclear. We therefore investigated subcellular localization of survivin in more than 3000 prostate cancer patients by quantitative immunohistochemistry and performed transcriptomics of 250 prostate cancer patients and healthy donors using publicly available datasets. Survivin (BIRC5) gene expression was increased in primary prostate cancers and metastases, but did not differ in recurrent vs non-recurrent prostate cancers. Survivin immunohistochemistry (IHC) staining was limited exclusively to the nucleus in 900 prostate cancers (40.0%), and accompanied by various levels of cytoplasmic positivity in 1338 tumors (59.4%). 0.5% of prostate cancers did not express survivin. Nuclear and cytoplasmic survivin staining intensities were strongly associated with each other, pT category, and higher Gleason scores. cytoplasmic but not nuclear survivin staining correlated with high tumor cell proliferation in prostate cancers. Strong cytoplasmic survivin staining, but not nuclear staining predicted an unfavorable outcome in univariate analyses. Multivariate Cox regression analysis showed that survivin is not an independent prognostic marker. In conclusion, we provide evidence that survivin expression is increased in prostate cancers, especially in metastatic disease, resulting in higher aggressiveness and tumor progression. In addition, subcellular compartmentalization is an important aspect of survivin cancer biology, as only cytoplasmic, but not nuclear survivin accumulation is linked to biological aggressiveness and prognosis of prostate cancers.

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“…When analyzed retrospectively,cancerpatientswithsurvivinoverexpressionintumorcellsexhibitedshortenedsurvival, associationwithunfavorablemarkersofdiseaseprogression,acceleratedratesofrecurrenceandincreased resistance to therapy [25,26]. The relationship between such an aggressive behavior and survivin has beendescribedinawidespectrumofmalignancies, e.g.incolorectalandgastriccarcinoma,inneuroblastoma as well as in prostatic carcinoma [2,27,28]. However, the association of survivin with prognosis inbreastcancerpatientshasalwaysbeenambiguous [14].…”

Section: Discussionmentioning

confidence: 99%

“…Thebalancebetweencellproliferationandapoptosis controlsnormalbreastdevelopmentaswellasmaintains cellular homeostasis of tissues. Furthermore, thereisastrongevidencethattumorgrowthisnot justtheresultofuncontrolledproliferation,butalso ofreducedapoptosis [2].Tumorcellscandevelopresistancetoapoptosisbyexpressionofanti-apoptotic proteins(inhibitorsofapoptosisproteins-IAP).IAP proteinswerefirstdiscoveredinbaculoviruses,where theywereshowntobeinvolvedinsuppressinghost celldeathresponsetoaviralinfection [3,4].Human genomeencodeseightIAPfamilymembers [5].Survivin,however,hasanumberofdistinctfeaturesnot sharedwithotherIAPs.Itistheshortestpolypeptide consistingof142aminoacidresidues.Theexpression of survivin is cell cycle-regulated and occurs in the G2/M phase. It is undetectable in most terminally differentiatednormalcells,butitisabundantinembryonicandfetaltissuesaswellasinamajorityofhuman malignancies including breast carcinomas [6].…”

Section: Introductionmentioning

confidence: 99%

Survivin in breast lesions: immunohistochemical analysis of 196 cases

Adamkov¹,

Drahošová²,

Chylíková³

et al. 2017

pjp

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Weexaminedthesurvivinexpressionpatternbyimmunohistochemistryin43fi-broadenomasand153ductalcarcinomasofthebreast.Thesubcellularlocalization ofsurvivin andtheintensityofimmunoreactionwereassessed.We analyzedthe differencesofsurvivinexpressionbetweenfibroadenomasandcarcinomas.Wealso correlatedthesurvivinexpressionpatternincarcinomaswithotherclinicomorphologicalparameterssuchastheageofpatients,thegradeandsizeofprimarytumor aswellasthelymphnodemetastasis.Overall,survivinwasdetectedin107/153 carcinomas(69.9%)andin26/43fibroadenomas(60.5%).Statisticalanalysisconfirmedsignificantcorrelationsbetweentheassessedparametersinfibroadenomas andcarcinomas.Gradeofcarcinomaswassignificantlyrelatedtosurvivinexpressioninbothsubcellularlocalizationandtheintensityofimmunoreaction.Tumor grade3wasassociatedwithnuclearpositivityandcombinednuclearandcytoplas-mic localization. Carcinomas larger than 20 mm showed nuclear and combined localizationin81%ofcasesandhigherintensityofsurvivinimmunoreactionwas alsonotablyrelatedtolargercarcinomas.Statisticallysignificantdifferenceswere alsoobservedbetweensubcellularsurvivinlocalizationandintensityofimmunoreaction.Ourresultsuggestthatnuclearaccumulationofsurvivinisassociatedwith proliferativefenotypeandsurvivinwasshowntobeaworseprognosticmarkerin breastductalcarcinoma.

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Augmented immunoexpression of survivin correlates with parameters of aggressiveness in prostate cancer

Cited by 12 publications

References 23 publications

Role of survivin expression in predicting biochemical recurrence after radical prostatectomy: a multi‐institutional study

Role of survivin expression in predicting biochemical recurrence after radical prostatectomy: a multi‐institutional study

Subcellular Compartmentalization of Survivin is Associated with Biological Aggressiveness and Prognosis in Prostate Cancer

Survivin in breast lesions: immunohistochemical analysis of 196 cases

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