Augmented Microfracture Technique Versus Microfracture in Talar Cartilage Restoration: A Systematic Review and Meta-Analysis

Abstract

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Operative management of osteochondral lesions of the talus: 2024 recommendations of the working group ‘clinical tissue regeneration’ of the German Society of Orthopedics and Traumatology (DGOU)

“…In smaller lesions, the additional scaffolds did not change the clinical outcome. However, patients benefit from biological support (65,66).…”

“…One study by Migliorini et al(64) with a 5-year follow-up compared M-BMS (matrix-associated BMS) using Chondro-Gide® against BMS, and they reported significantly better results with the additional scaffold in lesions sized between 2 and 3 cm². In a systematic review and meta-analysis, Wen et al(65) included studies comparing microfracture alone against microfracture with additional biological augmentation such as scaffolds, hyaluronic acid, platelet-rich plasma (PRP), Statement: Good results are reported for BMS in small lesions, including a high rate of return to sports. Unstable cartilage and small bony fragments should be removed.…”

Mesenchymal Stem Cell Studies in the Goat Model for Biomedical Research—A Review of the Scientific Literature

“…Studies with the goat model for cartilage repair have demonstrated success in therapy with fetal progenitor cells and Wharton’s jelly derived mesenchymal stem cells (hWJMSCs) [ 69 ] and BMSCs alone or associated with scaffolds or GDFs [ 69 , 71 , 72 ]. Zhang et al (2018) studied the potential of the hWJMSCs in a caprine model with a full-thickness femoral condyle articular cartilage defect, compared with the MF technique.…”