Augmenting Mesenchymal Stem Cell-Based Therapy of the Infarcted Myocardium with Statins

Alnasser, Sulaiman Mohammed; AL-Rasheedi, Mabrouk; Alreshidi, Mateq A.; Alqifari, Saleh F.; Haider, Khawaja Husnain

doi:10.1007/978-981-19-2655-6_20

Cited by 1 publication

(1 citation statement)

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“…Although using chemicals is considered a simple and preferred approach for MSC priming, approved drugs are advantageous because they are safe for human use and can be used for stem cell priming in clinics. Amongst the list of priming agents mentioned above, statins are gaining popularity[ 57 ]. Statins are a group of 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors approved for cholesterol lowering.…”

Section: Pretreatment Approaches Of Mscsmentioning

confidence: 99%

Priming mesenchymal stem cells to develop “super stem cells”

Haider

2024

World J Stem Cells

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The stem cell pre-treatment approaches at cellular and sub-cellular levels encompass physical manipulation of stem cells to growth factor treatment, genetic manipulation, and chemical and pharmacological treatment, each strategy having advantages and limitations. Most of these pre-treatment protocols are non-combinative. This editorial is a continuum of Li et al ’s published article and Wan et al ’s editorial focusing on the significance of pre-treatment strategies to enhance their stemness, immunoregulatory, and immunosuppressive properties. They have elaborated on the intricacies of the combinative pre-treatment protocol using pro-inflammatory cytokines and hypoxia. Applying a well-defined multi-pronged combinatorial strategy of mesenchymal stem cells (MSCs), pre-treatment based on the mechanistic understanding is expected to develop “Super MSCs”, which will create a transformative shift in MSC-based therapies in clinical settings, potentially revolutionizing the field. Once optimized, the standardized protocols may be used with slight modifications to pre-treat different stem cells to develop “super stem cells” with augmented stemness, functionality, and reparability for diverse clinical applications with better outcomes.

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Section: Pretreatment Approaches Of Mscsmentioning

confidence: 99%