“…Furthermore, the mechanical cues involved in onset of several signalling pathways present during normal physiologically conditions such as bone formation, development and homeostasis, have been known to positively influence the osteogenic properties of the graft (McCoy and O'Brien, 2010). We and others have demonstrated that the dynamic culture of MSC-based tissueengineered grafts was associated with improved cell survival within the grafts and enhanced mineralization both in vitro and in vivo (Zhang et al, 2009b;Zhang et al, 2010a;Meinel et al, 2005). The choice of different dynamic systems can play a part in optimal seeding, proliferation and differentiation of cells (Zhang et al, 2010b).…”