Aurelin, a novel antimicrobial peptide from jellyfish Aurelia aurita with structural features of defensins and channel-blocking toxins

Ovchinnikova, Tatiana V.; Balandin, Sergey V.; Алешина, Г. М.; Tagaev, Andrey A.; Leonova, Yulia F.; Krasnodembsky, Eugeny D.; Men’shenin, Alexander V.; Kokryakov, V. N.

doi:10.1016/j.bbrc.2006.07.078

Cited by 173 publications

(140 citation statements)

References 65 publications

Supporting

Mentioning

136

Contrasting

Unclassified

Order By: Relevance

“…A paralytic and cytolytic 27-kDa polypeptide, termed hydralysin, was isolated from the body of the cnidarian green hydra Chlorohydra viridissima rather than from the nematocysts [38]. A novel antimicrobial polypeptide aurelin was isolated from the mesoglea of the jellyfish Aurelia aurita [39]. In this manner, bioactive polypeptides can be found not only in the nematocysts but also in non-nematocyst tissue.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the bioactivities of water-soluble extracts from twelve deep-sea jellyfish species

et al. 2013

View full text Add to dashboard Cite

Many polypeptides isolated from shallow water cnidarian species have been utilized as valuable biochemical tools in both basic and applied biological sciences. Deepwater cnidarian species might be another potential resource for novel biochemical tools. However, because of limited access to cnidarian samples from deep-sea environments, bioactive polypeptides have never before been reported from this group. In this study, we collected twelve deep-sea jellyfish species (nine hydrozoans and three scyphozoans) using a plankton net that was specially designed for collecting deep-sea organisms, and prepared water-soluble extracts, presumably containing polypeptides, of these jellyfishes. The extracts were subjected to cytotoxicity, hemolytic activity, and crustacean lethal toxicity tests. In the cytotoxicity test, six out of the nine tested hydrozoan species showed activity. In the hemolytic activity test, only three hydrozoans showed activity and none of the scyphozoan jellyfishes showed activity. In the crustacean lethality test, two hydrozoan jellyfishes and all three of the tested scyphozoan jellyfishes showed lethal activity. These results revealed a high incidence of watersoluble bioactive substances occurring in these deepsea jellyfishes. Furthermore, all the heat-treated and the methanol-treated crude jellyfish extracts lost their bioactivities. Thus, it is likely that the bioactive compounds in the water-soluble extracts were unstable polypeptides (proteins). This is the first published report on bioactivities in extracts from deep-sea jellyfishes.

show abstract

Section: Discussionmentioning

confidence: 99%

Evaluation of the bioactivities of water-soluble extracts from twelve deep-sea jellyfish species

et al. 2013

View full text Add to dashboard Cite

show abstract

“…For example, Aurelia aurita, one of the most common jellyfish, contains the novel 40 aminoacid antimicrobial peptide aurelin. 45 Similarily, the antibacterial immune response gene encoding diptericin is restricted to insects of the Diptera group; 46 and the 11 kDa metal ion-binding S100 protein psoriasin protects epithelia in mammals but not in other animals from infection. 47 Taxonomically restricted host defense molecules appear to represent an extremely effective chemical warfare system to shape the colonizing microbiota and at the same time to cope with specific environmental challenges.…”

Section: How Does Hydra Control the Composition Of The Microbiota In mentioning

confidence: 99%

Understanding complex host-microbe interactions in Hydra

Bosch

2012

Gut Microbes

View full text Add to dashboard Cite

“…These have included several investigations of jellyfish constituents and toxins, some of which have important biomedical and pharmacological properties (e.g., Ovchinnikova et al 2006;Yu et al 2006;Masuda et al 2007;Ohta et al 2009;Balamurugan et al 2010;Mariottini and Pane 2010;Zhuang et al 2010;Morishige et al 2011;Zhuang et al 2012a, b;Kawabata et al 2013;Leone et al 2015). Research on some groups of jellyfish has led to a better understanding of ocular evolution (Nilsson et al 2005), as well as two Nobel Prizes: one in 1913 for the discovery of anaphylaxis, and another in 2008 for the discovery and development of green fluorescent protein (GFP).…”

Section: Other Uses Of Jellyfishmentioning

confidence: 99%

Jellyfish fisheries in the Americas: origin, state of the art, and perspectives on new fishing grounds

Brotz

Schiariti

López‐Martínez³

et al. 2016

Rev Fish Biol Fisheries

View full text Add to dashboard Cite

Jellyfish (primarily scyphomedusae) fisheries have a long history in Asia, where jellyfish have been caught and processed as food for centuries. More recently, jellyfish fisheries have expanded to the Western Hemisphere, often driven by demand from Asian buyers and collapses of more traditional local fish stocks. Jellyfish fisheries have been attempted in numerous countries in North, Central, and South America, with varying degrees of success. Here, we chronicle the arrival of jellyfish fisheries in the Americas and summarize relevant information on jellyfish fishing, processing, and management. Processing technology for edible jellyfish has not advanced, and presents major concerns for environmental and human health. The development of alternative processing technologies would help to eliminate these concerns and may open up new opportunities for markets and species. We also examine the biodiversity of jellyfish species that are targeted for fisheries in the Americas. Establishment of new jellyfish fisheries appears possible, but requires a specific combination of factors including high 123Rev Fish Biol Fisheries DOI 10.1007/s11160-016-9445-y abundances of particular species, processing knowledge dictated by the target market, and either inexpensive labor or industrialized processing facilities. More often than not, these factors are not altogether evaluated prior to attempting a new jellyfish fishery. As such, jellyfish fisheries are currently expanding much more rapidly than research on the subject, thereby putting ecosystems and stakeholders' livelihoods at risk.

show abstract

Aurelin, a novel antimicrobial peptide from jellyfish Aurelia aurita with structural features of defensins and channel-blocking toxins

Cited by 173 publications

References 65 publications

Evaluation of the bioactivities of water-soluble extracts from twelve deep-sea jellyfish species

Evaluation of the bioactivities of water-soluble extracts from twelve deep-sea jellyfish species

Understanding complex host-microbe interactions in Hydra

Jellyfish fisheries in the Americas: origin, state of the art, and perspectives on new fishing grounds

Contact Info

Product

Resources

About